Protein Alignment ninaC and MYH7

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Alignment Length: 1073
• Identity: 260/1073 - (24%)
• Similarity: 458/1073 - (42%)
• Gaps: 191/1073 - (17%)

  Fly   260 SESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKR 324
            ||.....|:.||.  ::.:..|:.:  :.::.:::.|     :||:...:..|.|      |.|.
Human    19 SEKERLEAQTRPF--DLKKDVFVPD--DKQEFVKAKI-----VSREGGKVTAETE------YGKT 68

  Fly   325 FDEKPEKMYP---------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQE 380
            ...|.:::..         ||:|.|....:..::.:|:.|......|::.|...:::|..:....
Human    69 VTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPV 133

  Fly   381 FPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKH---L 442
            :..|..|.||.|.|||..|||||::|.|||.||..:|.|.|:::|||.:||:.|.:.:|::   :
Human   134 YTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVI 198

  Fly   443 CYLGDGNR----GATGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVF 499
            ..:||.::    ...|.:|..|    .|:....||.|..|::|:|......:.||.|||::.|..
Human   199 AAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADI 263

  Fly   500 NMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPP-EVPPSKLKYR 563
            ..|:|||.||......:.::||||....  |::.:|.:..|..:..|.|..:.. |...:.:
Human   264 ETYLLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFISQGETTVASI--- 323

  Fly   564 RDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF--RQNGKYAEVENTDIVSR 626
             ||    .|.....:|....:.|..::..::.|:..||::.||::|  :|..:.||.:.|:
Human   324 -DD----AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTE---- 379

  Fly   627 IAELLRVDEKKFMWSLTNFIMVKGGIAER----RQYTT-----EEARDARDAVASTLYSRLVDFI 682
                 ..|:..::..|.:..::||....|    .:|.|     ::...|..|:|..:|.|:.:::
Human   380 -----EADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWM 439

  Fly   683 INRINMNMSF--PRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEML 745
            :.|||..:..  ||..|     |.:.|:.|||.|:.|..|||.||..||::|..:|..:|:.|..
Human   440 VTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 499

  Fly   746 EMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDL-----IMDRVSEKHSQF- 804
            |.:.|.|:...::|..:..|..:|:.||.|:..|:::.....:..|:     :.|....|.:.|
Human   500 EYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQ 564

  Fly   805 ----VKKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAG 865
                :|.......|:.||.|.:.|:...:...|:|.:...::..::.|..:.:..:|.|.   ||
Human   565 KPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AG 626

  Fly   866 NLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFV 930
             ...|.|..:.|   .:|..:..|:||   ....||..|..|.|.|              ..|||
Human   627 -ADAPIEKGKGK---AKKGSSFQTVSA---LHRENLNKLMTNLRST--------------HPHFV 670

  Fly   931 RCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL---AFDFDEP 992
            |||..:....|....:.:|..|::..|||:.:...:|||.:|:.:.:|.:||:.|   |....:.
Human   671 RCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735

  Fly   993 VEMTKDNCRLL-FLRLKMEGWALGKTKVF--------LRYYNDEFLARLYELQVKKVIKVQSMMR 1048
            ::..|...:|| .|.:....:..|.||||        |....||.|:|:       :.::|:..|
Human   736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRI-------ITRIQAQSR 793

  Fly  1049 ALLARKRVKGGKVFKLGKKGPEHHDVAASKIQ---KAFRGFRD------RVRLPPLVNEKSGQLN 1104
            .:|||...         ||..|..| :...||   :||.|.::      ..::.||:  ||.:..
Human   794 GVLARMEY---------KKLLERRD-SLLVIQWNIRAFMGVKNWPWMKLYFKIKPLL--KSAERE 846

  Fly  1105 ENTADFIRPFAK--------KWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTR 1161
            :..|.....|.:        :.|.|.:.:.::    :..|:..:|..||......:.....:|.:
Human   847 KEMASMKEEFTRLKEALEKSEARRKELEEKMV----SLLQEKNDLQLQVQAEQDNLADAEERCDQ 907

  Fly  1162 AVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMED 1226
            .:.         |..|   |...:|:|..||:     |.:.|             |..||.....
Human   908 LIK---------NKIQ---LEAKVKEMNERLE-----DEEEM-------------NAELTAKKRK 942

  Fly  1227 DEPWDSPLQRNPSMTSCALTYNAYKKEQACQTN 1259
            .|...|.|:|:  :....||....:||:....|
Human   943 LEDECSELKRD--IDDLELTLAKVEKEKHATEN 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	5/21 (24%)
		MYSc_Myo21	346..1022	CDD:276848	189/722 (26%)
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	255/1053 (24%)
		MYSc_Myh7	99..766	CDD:276881	189/714 (26%)
		Actin-binding	655..677		11/35 (31%)
		Actin-binding	757..771		5/13 (38%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935