Protein Alignment ninaC and MYH6

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 1081
• Identity: 266/1081 - (24%)
• Similarity: 453/1081 - (41%)
• Gaps: 214/1081 - (19%)

  Fly   254 QINDF--ISESLEKNAENRPMMVEMVEHPF--LTELIENEDEMRSDIAEMLELSRDVKTLYKEPE 314
            |:.||  .::.|.|:.:.|   :|....||  .||....:|  :.:..:...|||:...:..|.|
Human     5 QMADFGAAAQYLRKSEKER---LEAQTRPFDIRTECFVPDD--KEEFVKAKILSREGGKVIAETE 64

  Fly   315 ----LFVDRGYVKRFDEKPEKMYP-EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNS 374
                :.|....|  ..:.|.|... ||:|.|....:..::.:|:.|......|::.|...:::|.
Human    65 NGKTVTVKEDQV--LQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNP 127

  Fly   375 NEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLI 439
            .:....:..|..|.||.|.|||..|||||::|.|||.||..:|.|.|:::|||.:||:.|.:.:|
Human   128 YKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVI 192

  Fly   440 KHLCYLGD-GNRGA-------TGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGKTG 492
            ::...:.. |:||.       .|.:|..|    .|:....||.|..|::|:|......:.||.||
Human   193 QYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257

  Fly   493 KMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPP-EVP 556
            |::.|....|:|||.||......:.|:||||....  |::.:|.:..|..:..|.|..|.. ||.
Human   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQGEVS 320

  Fly   557 PSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGK--YAEVE 619
            .:.:    ||.|..:.....|:    .:.|..::...|.|:..||::.||::|:|..:  .||.:
Human   321 VASI----DDSEELMATDSAFD----VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPD 377

  Fly   620 NTDIVSRIAELLRVDEKKFMWSLT-------NFIMVKGGIAERRQYTTEEARDARDAVASTLYSR 677
            .|:...:.|.|:.::....:..|.       |..:.||...::..|:.       .|:|..:|.:
Human   378 GTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSI-------GALAKAVYEK 435

  Fly   678 LVDFIINRINMNMSF--PRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIF 740
            :.::::.|||..:..  ||..|     |.:.|:.|||.|:.|..|||.||..||::|..:|..:|
Human   436 MFNWMVTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495

  Fly   741 ISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDL-----IMDRVSEK 800
            :.|..|.:.|.|:...::|..:..|..:|:.||.|:..|:::.....:..|:     :.|....|
Human   496 VLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGK 560

  Fly   801 HSQF-----VKKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQ 860
            .:.|     :|.......|:.||.|.:.|:...:.:.|:|.:...::..::.|..:.:..:|::.
Human   561 SNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSY 625

  Fly   861 LT---------KAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLL 916
            .|         |.|               ::|..:..|:||   ....||..|..|.|.|
Human   626 ATADTGDSGKSKGG---------------KKKGSSFQTVSA---LHRENLNKLMTNLRTT----- 667

  Fly   917 KMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRR 981
                     ..||||||..:....|....:.:|..|::..|||:.:...:|||.:|:.:.:|.:|
Human   668 ---------HPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 723

  Fly   982 YQFL---AFDFDEPVEMTKDNCRLL-FLRLKMEGWALGKTKVF--------LRYYNDEFLARLYE 1034
            |:.|   |....:.::..|...:|| .|.:....:..|.||||        |....||.|:|:
Human   724 YRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRI-- 786

  Fly  1035 LQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQ---KAFRGFRD------RV 1090
                 :.::|:..|..|.|...         ||..|..| |...||   :||.|.::      ..
Human   787 -----ITRMQAQARGQLMRIEF---------KKIVERRD-ALLVIQWNIRAFMGVKNWPWMKLYF 836

  Fly  1091 RLPPLVNEKSGQLNENTADFIRPFA--KKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMV 1153
            ::.||:  ||.:..:..|.....|.  |:..|||         .||.::.          .::||
Human   837 KIKPLL--KSAETEKEMATMKEEFGRIKETLEKS---------EARRKEL----------EEKMV 880

  Fly  1154 AGL---NKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAF 1215
            :.|   |.....|..|:.|:.:...               |.||:          ..|.|..:|.
Human   881 SLLQEKNDLQLQVQAEQDNLNDAEE---------------RCDQL----------IKNKIQLEAK 920

  Fly  1216 PNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQAC 1256
            ..: :.:.:||:|..::           .||....|.|..|
Human   921 VKE-MNERLEDEEEMNA-----------ELTAKKRKLEDEC 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	9/31 (29%)
		MYSc_Myo21	346..1022	CDD:276848	189/730 (26%)
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	9/45 (20%)
		MYSc_class_II	99..768	CDD:276951	189/722 (26%)
		Actin-binding	657..679		11/35 (31%)
		Actin-binding	759..773		5/13 (38%)
		Myosin_tail_1	848..1925	CDD:460256	29/158 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939