Protein Alignment ninaC and MYO1F

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001427538.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1192
• Identity: 284/1192 - (23%)
• Similarity: 474/1192 - (39%)
• Gaps: 260/1192 - (21%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            :|:..|....::.|..:||.|.:....:::||.:|:|:|..:....|.......|:..::.||.|
Human    20 DDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYENPP 84

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            ||:::.|..|::||...|.|.:::||||.:||:..|:.::.::..:..|     |.....:|.|:
Human    85 HIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGG-----GEKVQHVKDII 144

  Fly   465 M--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHI 521
            :        ..||.|..||:|:|....:.:.|.:.|:..|...:.::|||.||...:..:.||||
Human   145 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHI 209

  Fly   522 FYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDF 586
            :|...:..:|: |.:...|.....|.||.       ....|:.|..:...: :.|..:.::.|..
Human   210 YYQLLEGASQE-QRQNLGLMTPDYYYYLN-------QSDTYQVDGTDDRSD-FGETLSAMQVIGI 265

  Fly   587 NHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVK-- 649
            .....:.|.:::|.||::|||.|.::|.||.||:.|:::..|.||.:|..:....||:..|..
Human   266 PPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRW 330

  Fly   650 GGIAERRQYT--TEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFE 712
            ||.:|....|  .|:|...|||:|..||:||.||::..||..|..|:..:    :|.:.|::|||
Human   331 GGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEY----SIGVLDIYGFE 391

  Fly   713 CFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED-----IDTINLNFYDNKTALDNLLTK 772
            .|.:||.||..||.:||::     |:|||...|:.|.|:     |....:.:::||...|.:..|
Human   392 IFQKNGFEQFCINFVNEKL-----QQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENK 451

  Fly   773 --PDGLFYIIDD------ASRSCQDQDLI--MDRVSEKHSQFVKKHTATEISVAHYTGRIIYDTR 827
              |.|:..::||      |:....||.|:  :......|..|  ...:....:.||.|::.||..
Human   452 LSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHF--NSWSAGFVIHHYAGKVSYDVS 514

  Fly   828 AFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSA 892
            .|.:.|||.:..::||..::|....:.::|..:|              ..|:..|.|.|.:.:.
Human   515 GFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKL--------------DGDKKGRPSTAGSKIK- 564

  Fly   893 GCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFH------------ 945
               .|.|:|  :|...|.|               .|::|||:.:...:||.:.
Human   565 ---KQANDL--VATLMRCT---------------PHYIRCIKPNETKRPRDWEENRTGDSPPRGD 609

  Fly   946 SDVVQQQMKALGVLDTVIARQKGFSSRL---------PFDEFLRRYQFLA------FDFDEPVEM 995
            |.....|.:|.|.:.......:|..|||         |.:....||..|.      :..||
Human   610 SAYPPHQSQAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTPETWPRWRGDE---- 670

  Fly   996 TKDNCRLLFLRLKME--GWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKG 1058
             :...:.|...:.||  .:.:|.||||::  |.|.|..|.|::.:|
Human   671 -RQGVQHLLRAVNMEPDQYQMGSTKVFVK--NPESLFLLEEVRERK------------------- 713

  Fly  1059 GKVFKLGKKGPEHHDVAASKIQKAFR---------GFRDRVRLPPLVNEKSGQLNENTADFI--- 1111
                         .|..|..||||:|         ..|:... ..|:|:|..:.|....:|:
Human   714 -------------FDGFARTIQKAWRRHVAVRKYEEMREEAS-NILLNKKERRRNSINRNFVGDY 764

  Fly  1112 -----RPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRM------VAGLNKCTRAVPF 1165
                 ||..:::..|              ::.|:.:..|..|::|.      :....||...:..
Human   765 LGLEERPELRQFLGK--------------RERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGR 815

  Fly  1166 ERINMREVNSSQLGPLPVPIKKMPFRLD------------QIPFYDTQYMVDPANSISRQAFPNQ 1218
            |::.    ...:.|.:...:||   ::|            |..|:..|  .|.|:|.....|..:
Human   816 EKVK----KGPEKGQVCEVLKK---KVDIQALRGVSLSTRQDDFFILQ--EDAADSFLESVFKTE 871

  Fly  1219 ---LLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQ 1280
               ||.:..|  |....||   |...|..|.:.. |||     .|...|.....:::| |.|...
Human   872 FVSLLCKRFE--EATRRPL---PLTFSDTLQFRV-KKE-----GWGGGGTRSVTFSRG-FGDLAV 924

  Fly  1281 LRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPN 1345
            |:.....:.::..:....|......    |:.:...||:|.....|.|.||..|
Human   925 LKVGGRTLTVSVGDGLPKSSKPTRK----GMAKGKPRRSSQAPTRAAPAPPRGM----------- 974

  Fly  1346 QQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRG---SETNTYDFNNR 1407
                   .|:..|||.....|.....:.|.....|.......|..:..||.   ||.|| :|.|
Human   975 -------DRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNT-EFLN- 1030

  Fly  1408 RGSDSGDQHTFQPPKLRSTGRR 1429
                ..||......:.||.|:|
Human  1031 ----VPDQGMAGMQRKRSVGQR 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	192/731 (26%)
MYO1F	NP_001427538.1	None