Protein Alignment ninaC and MYO1B

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 868
• Identity: 209/868 - (24%)
• Similarity: 384/868 - (44%)
• Gaps: 175/868 - (20%)

  Fly   336 DLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPH 400
            |:..||...:|..|.:|:.|....|.|::||.:::|:|.......:..|...:||.::..|..||
Human    39 DMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPH 103

  Fly   401 IFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKH---LCYLGDGNRGATGRVESSIKA 462
            ||:::|.||:.:....:.|.|:::|||.:||:..::|::.:   :|..|........::..|...
Human   104 IFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPV 168

  Fly   463 ILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYD 527
            :....||.|..|::|:|......:.|...|...|.|.:.|:|||.||......:.|||:||....
Human   169 LEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLS 233

  Fly   528 FINQQ--NQLKEYNLKAD-RNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHK 589
            ..:::  |:||   |:.| ..|.||.:      ...|....|...|   :|...|.::.:.|...
Human   234 GASEELLNKLK---LERDFSRYNYLSL------DSAKVNGVDDAAN---FRTVRNAMQIVGFMDH 286

  Fly   590 QLETVRKVLAAILNIGNIRF----RQNG-KYAEVENTDIVSRIAELLRVD----EKKFMWSLTNF 645
            :.|:|..|:||:|.:|||.|    |.|| ..:::::.:.:..|.||..:|    |:.|     :|
Human   287 EAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAF-----SF 346

  Fly   646 IMVKGGIAERRQYTT----EEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIH 706
            ..|:   |::.:.:|    .:|..||||:|..|||||..:::||||.::.....|......::
Human   347 RTVE---AKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVL-- 406

  Fly   707 DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLT 771
            |::|||.|..|..||.:||..||::|..:.:.....|..|...|||:..::::::|....|.:..
Human   407 DIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIEN 471

  Fly   772 KPDGLFYIIDDASRSCQDQDLIMDRV-SEKHSQFVKKHTATE-------------------ISVA 816
            ..:|:..::|:   .|.....:.|.. .||.:|....|...|                   ..:.
Human   472 NTNGILAMLDE---ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQ 533

  Fly   817 HYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESE 881
            ||.|:::|....|.|.|.|.:                                      ::|.|:
Human   534 HYAGKVLYQVEGFVDKNNDLL--------------------------------------YRDLSQ 560

  Fly   882 ---RKSYAL--NTLSAGCISQVNNLR--TLAANFRFTCLTLLKML-SQNANLGVHFVRCIRADLE 938
               :.|:||  :....|..:::|..|  |..:.|:.:..||:|.| ::|.|    ::|||:.:.:
Human   561 AMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPN----YIRCIKPNDK 621

  Fly   939 YKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFD----FDEPVEMTKDN 999
            .....|:..:|..|::.||:|:.|..|:.|::.|..::..|.||:.|...    :..|   .:..
Human   622 KAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGP---ARSG 683

  Fly  1000 CRLLF--LRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVF 1062
            ..:||  |.:.:|.::.|::|:|:|  |...|.:|.:|:.:::
Human   684 VEVLFNELEIPVEEYSFGRSKIFIR--NPRTLFKLEDLRKQRL---------------------- 724

  Fly  1063 KLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSG----------------QLNENTADFI 1111
                      :..|:.|||.:||::.|...  |:.:||.                |..:::|..|
Human   725 ----------EDLATLIQKIYRGWKCRTHF--LLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVI 777

  Fly  1112 RPFAKKWREKSIFQVLLHYRAAR 1134
            :.:.:.|:.:.|.:.|.|.:..:
Human   778 QSYIRGWKARKILRELKHQKRCK 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	184/728 (25%)
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	184/728 (25%)
		IQ	769..791	CDD:197470	4/21 (19%)
		Myosin_TH1	961..1138	CDD:461801