Protein Alignment ninaC and Myo1a

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001074688.1
• Gene: Myo1a / 432516
• MGIID: 107732
• Length: 1043
• Species: Mus musculus
• Alignment Length: 967
• Identity: 236/967 - (24%)
• Similarity: 407/967 - (42%)
• Gaps: 209/967 - (21%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            |||..||...:|::|::|:.|....|.|::||::::|:|..|....:..||.||||..:..|.:|
Mouse    11 EDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDYTFYELKP 75

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKH---LCYLGDGNRGATGRVESSIK 461
            ||:::|::|||.:......|.|:::|||.:||:..::|::.:   :|..|:.......::..|..
Mouse    76 HIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNP 140

  Fly   462 AILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFY 526
            .:....||.|..||:|:|......:.|...|...|.|...|:|||.||......:.||||||...
Mouse   141 VLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFYQLL 205

  Fly   527 DFINQQNQLKEYNLKADRN-YRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQ 590
            ...:.| .||...|:.|.: |.||.  .||  ||:....|     ...:|..::.:..|.|:.::
Mouse   206 AGADAQ-LLKALKLEEDTSVYGYLN--GEV--SKVNGMDD-----ASNFRAVQHAMSVIGFSEEE 260

  Fly   591 LETVRKVLAAILNIGNIR----FRQNGKYAE-VENTDIVSRIAELLRVDEKKFMWSLTNFIMVKG 650
            :..|.:|.|.:|.:||::    |:.||..|. :.:...:..|.|::.::..:...:|.:..|..|
Mouse   261 IRQVLEVTALVLKLGNVKLTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETG 325

  Fly   651 GIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII-IHDMFGFECF 714
            ...........:|:.||||:|..:||||.|:|:.|||.::   :...|:...:: :.|::|||..
Mouse   326 KEKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESI---KVGTGEKKKVMGVLDIYGFEIL 387

  Fly   715 NRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYI 779
            ..|..||.:||..||::|..:.:.....|..|.:.|.|....:.::||....:.:.....|:..:
Mouse   388 EDNSFEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGILAM 452

  Fly   780 IDDASRSCQDQDLIMD--------RVSEKHSQFVKKHTATE------------ISVAHYTGRIIY 824
            :|:   .|....::.|        ::..|||.:..|.:...            ..::||.|::.|
Mouse   453 LDE---ECLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVTY 514

  Fly   825 DTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNT 889
            :...|.|.|.|.:..::.:|...:....:..:|.....|..:|..|
Mouse   515 NVTGFIDKNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEASLKRP------------------- 560

  Fly   890 LSAGCISQVNNLRTLAANFRFTCLTLLKML-SQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQM 953
                        .|....|:.:...|:|.| |:|.|    ::|||:.:.:.:...|.|::|..|.
Mouse   561 ------------PTAGTQFKNSVAVLMKNLYSKNPN----YIRCIKPNDQQQKGRFTSEMVMVQA 609

  Fly   954 KALGVLDTVIARQKGFSSRLPFDEFLRRYQFLA--------FDFDEPVEMTKDNCRLLFLRLKME 1010
            :.||:|:.|..|:.|::.|..:..||.||:.|:        .|..|.||..     |..|.|..|
Mouse   610 RYLGLLENVRVRRAGYAFRQGYKPFLERYRLLSRSTWPRWNGDDREGVEKV-----LGSLTLSSE 669

  Fly  1011 GWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVA 1075
            ..|.||||:|:|...     .|:.|:.::.:::|.:
Mouse   670 ELAYGKTKIFIRSPK-----TLFYLEEQRRLRLQQL----------------------------- 700

  Fly  1076 ASKIQKAFRGFRDRVRLPPLVNEKS-----------------GQLNENTADFIRPFAKKWREKSI 1123
            |:.|||.:||:|.|.....:  .||                 |::..:.. .|:.|.:.||.:.
Mouse   701 ATLIQKVYRGWRCRTHYQQM--RKSQILISAWFRGNKQKKHYGKIRSSVL-LIQAFVRGWRARK- 761

  Fly  1124 FQVLLHYRAARFQDFVNLSQQVHIYN---QRMVAGLNK---CTR-------AVPFERIN------ 1169
                 :|| ..|:....|:....||.   |:.:..|.|   .|:       |.|:...|
Mouse   762 -----NYR-KYFRSGAALTLANFIYQSMAQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQEL 820

  Fly  1170 -----------------------MRE-VNSSQL-------GPLPVPIKKMPFRLDQI 1195
                                   :|| :.:|:|       .|..|||   |||.|.|
Mouse   821 QRLFYQWKCKKFRDQLSPKQVQTLREKLCASELFKGKKASYPQSVPI---PFRGDYI 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	186/714 (26%)
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	186/714 (26%)
		Actin-binding. /evidence=ECO:0000255	571..593		9/25 (36%)
		IQ	742..764	CDD:197470	4/28 (14%)
		Myosin_TH1	847..1042	CDD:461801	11/31 (35%)