DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and myo3a

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_991142.2	Gene:	myo3a / 402814	ZFINID:	ZDB-GENE-041026-4	Length:	1775	Species:	Danio rerio

Alignment Length:	1668	Identity:	477/1668 - (28%)
Similarity:	770/1668 - (46%)	Gaps:	293/1668 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQV--SIEEEYRTLRDYC 68
            :...|||:|.:||.|.|.:|...||::.....:....|:||  .|..|.:  .||.||..|:...
Zfish    11 FDSFPDPSDTWEIIETIGKGTYGKVYKVHNKVDGSKAAVKI--LDPIHDIDEEIEAEYNILKALS 73

  Fly    69 DHPNLPEFYGV-YKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRA 132
            ||||:.:|:|: ||.....| |::|.|:|.|.||:..|:...:||...||.|..||:|:.|....
Zfish    74 DHPNVVKFFGMFYKKDVKTG-DQLWLVLELCNGGSVTDLAKGMLKRGDRMEEPIIAFILHEALMG 137

  Fly   133 AIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMES 197
            ...|:.|..:|||::|:|||||.:|.:||.|||:|.|:.:|..:|.|.:|:|.||||||::..:.
Zfish   138 LQHLHVNKTIHRDVKGNNILLTTDGGIKLVDFGVSAQLTNTRLRRNTSVGTPFWMAPEVIACEQQ 202

  Fly   198 REPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISES 262
            .:.....|.|||:||||.|||.||.||.|::||.||:|:|.|||||||.:|..||...||||.:.
Zfish   203 LDSTYDERCDVWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPTLHQPELWSNDFNDFIRKC 267

  Fly   263 LEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKR-FD 326
            |.|:.|.||.::::::|.|:.:::..|..::..:.|:::|::.:..:.|...|    |...| .|
Zfish   268 LIKDFELRPNVLDLLQHVFIKQIVGREKTLQKQLMELIDLNQQMGIIEKTSLL----GKSDRDSD 328

  Fly   327 EKPEKMY----------------PEDLAALENPVDEN-IIESLRHRILMGESYSFIGDILLSLNS 374
            .:.|:::                .:|||.|| .:||| |.|.|:.|....:.|:::||||:::|.
Zfish   329 SRHERIHTKKNSYMKSQSQTCDDADDLATLE-VLDENTITEQLQRRYTKEQIYTYVGDILIAVNP 392

  Fly   375 NEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLI 439
            ....:.:..|....|....|:.|.|||::|||||||.|:.:...|.||:||||.:||:.:|.||:
Zfish   393 FHKTELYTPEHTKSYVGAKRTSNPPHIYAVADIAYQSMVSYNADQCIVISGESGAGKTESAHLLV 457

  Fly   440 KHLCYLGDGNRGATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGK--------TG 492
            :.|..||..|...   ::..|..:..||    ||.|.:|::|:|        |||        .|
Zfish   458 QQLTVLGKANNRT---LQEKILLVNSLVEAFGNACTVINDNSSR--------FGKYLEMKFTCGG 511

  Fly   493 KMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLR------V 551
            .:.||..:.|:|||.||......:.|||||||.|..:.::.:|..|.|...:..|||.      |
Zfish   512 TVVGAQISDYLLEKSRVVHHAVGERNFHIFYYIYAGLAERKKLGHYKLSDSKTPRYLHNENVKLV 576

  Fly   552 PPEVPPSKLKYRRDDPEGNV---ERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF---- 609
            |             |..||.   |::...|...:.|.|..::|.:|..:||.|||.|::.|
Zfish   577 P-------------DIVGNAFYKEQFETVEQCFKVIGFTLEELGSVYGILAGILNTGDVEFTSVA 628

  Fly   610 --RQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVAS 672
              .|..| :.:.|..::...|.||.:...:...:||:..:|..|....|..|.|:|.:.|||:..
Zfish   629 SEHQTDK-SNISNMAVLESAASLLCIRADELQEALTSHCVVTRGETIVRSNTVEKATEVRDAMGK 692

  Fly   673 TLYSRLVDFIINRINMNMSFPRAVFGDTNA---IIIHDMFGFECFNRNGLEQLMINTLNEQMQYH 734
            .||.||..:|:|||| ::..|....|:.:.   |.|.|:||||.|.||..|||.||..|||:|::
Zfish   693 ALYGRLFSWIVNRIN-SLLKPDNQSGEDDKGLNIGILDIFGFENFKRNSFEQLCINIANEQIQFY 756

  Fly   735 YNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ--DQDLIMDRV 797
            :||.||..|..|...||:|...:.:.||:..||..|.||.|:..::|:.||..|  ||.|:
Zfish   757 FNQHIFAWEQDEYLNEDVDARVIEYEDNRPLLDLFLQKPMGMLSLLDEESRFPQATDQTLV---- 817

  Fly   798 SEKHSQFVK-------KHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIML 855
             ||....:|       |.......:.||.|::||:...|...|||.:|.:::...|||.:|....
Zfish   818 -EKFEDNLKSKNFWRPKRVDLGFGIHHYAGKVIYNAGGFLAKNRDALPADIVLLLRSSENELTRK 881

  Fly   856 MFTNQLTKAGNLT--------------------------MPFEAVQHKDESERK--------SYA 886
            :.|:.|||.|||.                          :.|.:|...:.|.||        ..|
Zfish   882 LVTHPLTKTGNLAHTKGKAVGSARMGTQQSQRFAKLDCLLLFSSVSFSESSSRKLTPPIDKSMLA 946

  Fly   887 L------NTLSAGCIS----QVNNLR--TLAANFRFTCLTLL-KMLSQNANLGVHFVRCIRADLE 938
            |      .|.|.|..:    :..|::  |:|:.||::.:.|| ||::...    ||||||:.:.:
Zfish   947 LPVDSVQTTESTGDTTHHPRETTNMKTQTVASYFRYSLMDLLSKMVAGQP----HFVRCIKPNND 1007

  Fly   939 YKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLL 1003
            .:...|..:.|..|::..|:|:|...|::|:|.|:.|:.|:.||..|||..:|...::.:.|.::
Zfish  1008 RQAHKFDREKVLIQLRYTGILETAKIRRQGYSHRILFNNFIERYSILAFRANEEPAISPETCAVI 1072

  Fly  1004 FLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKG 1068
            ..:.|:|.|.||||||||:||:.|.|..:......:::.||:.:|..:|.||      :.|.|
Zfish  1073 LEKAKLENWILGKTKVFLKYYHVEQLNLMVRQTTDRIVLVQAYVRGWMAFKR------YCLLK-- 1129

  Fly  1069 PEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYR-- 1131
             |..:.:|..:|.|:||.:.|   ..:.:::|...:|.....::.:.:.:..:..::.||..:
Zfish  1130 -EKREQSAVVLQSAYRGHKAR---KSIADDRSKAKSEIVFTQLQAWCRGYLARQNYKELLDEKNK 1190

  Fly  1132 -AARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPV----PIKKMPFR 1191
             ||:.        |.|...|:......:...|:..|.....|    ::..:|:    |:.:.|.:
Zfish  1191 AAAKI--------QAHYRGQKERKSFQRKKEAMQKENTEKTE----RVTEVPLEADDPVSEEPLQ 1243

  Fly  1192 LDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQA- 1255
                  ...:..:|.|:  .:.|...|...:...:.:.:....:||.:::...|..::...|:.
Zfish  1244 ------EGGEVEMDDAD--EKAAVVLQSNYRGYRERKKFKERQERNKTLSGDELDASSSTPEEMT 1300

  Fly  1256 -----------CQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNW 1309
                       .|.|.::  |.:.:...|...||:|..:            |.....||:..
Zfish  1301 SGEDLEATREDTQENVEK--EGNEVEEGGGDEDPEQEAK------------AATVLQSNFRG--- 1348

  Fly  1310 GVHRSGSR-----------RNSLKG------YAAPPPPPPP-----MPSSNYYRNNP-------- 1344
              |:...|           :..:|.      ...|.||||.     .....:...||
Zfish  1349 --HKERKRLQEEGKIPVRGKKEIKSPTDEEELPIPDPPPPEELMEFSEEMEFTEENPPGEEDEAK 1411

  Fly  1345 -----------NQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSED----PPFNFKAMLRKTNYP 1394
                       :::::..|:....|......|:.:...:|.|.:.:    ||...:......:.|
Zfish  1412 AAVVLQSNFRGHKERKRLQEEGKIPKKKTKEEMDDPGASEPDIAIEELPPPPLELEHDQELDSSP 1476

  Fly  1395 RGSETN---TYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQRAP 1456
            .|.:..   |...:|.||      |. :..:||:   ..::..|...|:|:      ..:|:...
Zfish  1477 SGGDEEHAATVLQSNFRG------HR-ERKRLRA---EKEEATGGGQSTGD------VEEQENND 1525

  Fly  1457 TLRQSPASVGRSFEDSNARSFEEAGSYVEEEIAPGI--TLSGY 1497
            .|..:...:.|       |..||.|.|.||:.|..|  ...||
Zfish  1526 VLDITDVQLER-------REEEEEGQYDEEQAAIKIQSNFRGY 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	119/275 (43%)
		S_TKc	16..282	CDD:214567	115/268 (43%)
		MYSc	327..1034	CDD:214580	258/809 (32%)
		MYSc_Myo21	346..1022	CDD:276848	246/762 (32%)
myo3a	NP_991142.2	PKc_like	2..287	CDD:328722	119/278 (43%)
myo3a	NP_991142.2	MYSc_Myo3	364..1091	CDD:276830	245/761 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49486
Inparanoid	1	1.050	602	1.000	Inparanoid score	I910
OMA	1	1.010	-	-		QHG52654
OrthoDB	1	1.010	-	-		D25137at33208
OrthoFinder	1	1.000	-	-		FOG0003766
OrthoInspector	1	1.000	-	-		otm25542
orthoMCL	1	0.900	-	-		OOG6_104503
Panther	1	1.100	-	-	O	PTHR46256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880