Protein Alignment ninaC and Myo3b

DIOPT Version :9

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_796350.2
• Gene: Myo3b / 329421
• MGIID: 2448580
• Length: 1333
• Species: Mus musculus
• Alignment Length: 1160
• Identity: 385/1160 - (33%)
• Similarity: 618/1160 - (53%)
• Gaps: 106/1160 - (9%)

  Fly     2 MYLPYAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALK----IQHYDEEHQVSIEEEYR 62
            |.|....||||.:.:||.|.|.:|...||::.....:..:.|:|    :...|||    ||.||.
Mouse    29 MMLGLESLPDPMETWEIIETIGKGTYGKVYKVANKRDGSLAAVKVLDPVSDMDEE----IEAEYN 89

  Fly    63 TLRDYCDHPNLPEFYGV-YKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYII 126
            .|:....|||:.:|||: ||..:..| .::|.|:|.|.||:..::|..||:..:|:.|..|:||:
Mouse    90 ILQFLPSHPNVVKFYGMFYKADRCVG-GQLWLVLELCNGGSVTELVKGLLRCGKRLDEAVISYIL 153

  Fly   127 RETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEV 191
            .........|:.:.::|||::|:|||||..|.|||.|||:|.|:.||..:|.|.:|:|.||||||
Mouse   154 YGALLGLQHLHCHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 218

  Fly   192 VSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQIN 256
            ::..:..:.....|.|||:||||.|||.||.||..:|||.:.:|:|.|||||||:.|.:|.::.|
Mouse   219 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPDSWCEEFN 283

  Fly   257 DFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGY 321
            .|||:.|.|:.|.||.:..:::|||:.........::..:|::|:..:....:.|.....:..|.
Mouse   284 HFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLCLQKQLAKVLQDQKHRNPVAKTRHERMHTGR 348

  Fly   322 VKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFH 386
            ..|.::..:....:||..||...::.||..|:.|......|:::||||::||..:....:..:|.
Mouse   349 PHRVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYADALIYTYVGDILIALNPFQNLSIYSPQFS 413

  Fly   387 AKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGN-- 449
            ..|....||.|.||||:.||.|||.::...:.|.||:||||.|||:.:|.|:::||.:||..:
Mouse   414 RLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVISGESGSGKTESAHLIVQHLTFLGKADNQ 478

  Fly   450 --RGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATT 512
              |....:|.|.::|   ..||.|.:|::|:|......:.|..||.:.||..:.|:|||.||...
Mouse   479 TLRQKILQVNSLVEA---FGNARTAINDNSSRFGKYLEMMFTPTGAVMGARISEYLLEKSRVIQQ 540

  Fly   513 DGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYL-----RVPPEVPPSKLKYRRDDPEGNVE 572
            ...:.|||||||.|..:..|.:|.|:.|..::..||:     ||..:: .||..||        .
Mouse   541 AAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRYIAGETERVMQDI-TSKESYR--------T 596

  Fly   573 RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF------RQNGKYAEVENTDIVSRIAELL 631
            ::...::..:.|.|..|::.:|.::||.|||||:|.|      .|..| :||.|.:.:...|.:|
Mouse   597 QFEAIQHCFKIIGFADKEVHSVYRILAGILNIGSIEFAAISSQHQTDK-SEVPNPEALENAACVL 660

  Fly   632 RVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAV 696
            .:..::...:||:..:|..|....|..|.:.|.|.|||::..||.||..:|:||||..:...:.:
Mouse   661 CISSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLLQPDKNI 725

  Fly   697 FG--DTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNF 759
            ..  |...:.|.|:||||.|.||..|||.||..|||:||::||.:|..|.:|.:.|.:|.:.:.:
Mouse   726 CSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYKNEGVDAVLVQY 790

  Fly   760 YDNKTALDNLLTKPDGLFYIIDDASRSCQ--DQDLIMDRVSEKHSQFVKKHTATEI--SVAHYTG 820
            .||:..||..|.||.||..::|:.||..|  ||.|:.........:|..:....|:  .:.||.|
Mouse   791 EDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDNLRCKFFWRPKGVELCFGIQHYAG 855

  Fly   821 RIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNL------------TMP--- 870
            .::||.....:.|||.:|.:::...|:|.::.:..:|:..|||.|||            ::|
Mouse   856 PVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRAKITASSRSLPPHF 920

  Fly   871 ---------FEAVQHKDESERKSYALNTLSAGCISQVNNLR--TLAANFRFTCLTLL-KMLSQNA 923
                     .|.::|.:|:                  .|::  |:|:.||::.:.|| ||:....
Mouse   921 SAGRAKVDTLEVIRHPEET------------------TNMKRQTMASYFRYSLMDLLSKMVVGQP 967

  Fly   924 NLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFD 988
                ||:|||:.:.:.|...|..|.|..|:::.|:|:||..|::|:|.|:.|:||::||.:|||.
Mouse   968 ----HFIRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYLAFR 1028

  Fly   989 FDEPVEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLAR 1053
            ..:.....|::|..:..:.:::.|.||||||||:||:.|.|..|....:.:|:.:|:..:..|..
Mouse  1029 AHQTPPANKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVMGRVVMLQAYTKGWLGA 1093

  Fly  1054 KRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTA 1108
            :|.|..|         |..:..|..||.|:||:..|.:|    .::|.:.:|:.|
Mouse  1094 RRYKRAK---------EKREKGAITIQSAWRGYDARRKL----KQRSRRRSESEA 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	115/277 (42%)
		S_TKc	16..282	CDD:214567	111/270 (41%)
		MYSc	327..1034	CDD:214580	244/754 (32%)
		MYSc_Myo21	346..1022	CDD:276848	234/723 (32%)
Myo3b	NP_796350.2	STKc_myosinIIIB_N	20..310	CDD:270808	118/285 (41%)
		S_TKc	43..309	CDD:214567	111/270 (41%)
		MYSc	362..1069	CDD:214580	242/741 (33%)
		MYSc_Myo3	373..1062	CDD:276830	234/723 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52654
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003766
OrthoInspector	1	1.000	-	-		otm42503
orthoMCL	1	0.900	-	-		OOG6_104503
Panther	1	1.100	-	-	O	PTHR46256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830