Protein Alignment ninaC and Myo5c

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_006243475.1
• Gene: Myo5c / 315820
• RGDID: 1309994
• Length: 1749
• Species: Rattus norvegicus
• Alignment Length: 1082
• Identity: 267/1082 - (24%)
• Similarity: 447/1082 - (41%)
• Gaps: 206/1082 - (19%)

  Fly   305 DVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRH-RILMGES------- 361
            |.:.::|..|:..|    .|..::..::..||...|:.|||...:..||: .||:||:
  Rat    17 DPEEVWKSAEIAKD----YRVGDQVLRLLLEDGTELDYPVDPGSLPPLRNPDILVGENDLTALSY 77

  Fly   362 --------------------YSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVAD 406
                                |::.|.||:::|..:....:.......|..::..:..||||:||:
  Rat    78 LHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAE 142

  Fly   407 IAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLV---- 467
            .||:.|..:...|.|::||||.:||:.:||..:::...:...:..|  .||..:.|...:.
  Rat   143 EAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNA--HVEEKVLASNPITEAVG 205

  Fly   468 NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQ 532
            ||.|..|::|:|......::|.:..::.||....|:|||.||......:.|:||||...... ||
  Rat   206 NAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFYQLCASA-QQ 269

  Fly   533 NQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKV 597
            ::.|...|.:...:.|.|:........:    ||.....|..:.|..:....||   |:: |.|:
  Rat   270 SEFKHLKLGSAEEFNYTRMGGNTVIEGV----DDRADMAETQKTFTLLGFKKDF---QMD-VFKI 326

  Fly   598 LAAILNIGNIRFRQ--NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTT 660
            |||||::||::...  |.:.|..|:...:....|||.::..|....|.|..:|.......:..|.
  Rat   327 LAAILHLGNVQVTTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPMTR 391

  Fly   661 EEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII-IHDMFGFECFNRNGLEQLMI 724
            .:|.:||||:|..:|:.|.|||:.:||..:.|.    |..:..| :.|::|||.|:.|..||..|
  Rat   392 PQAINARDALAKKIYAHLFDFIVEQINQALHFS----GKQHTFIGVLDIYGFETFDVNSFEQFCI 452

  Fly   725 NTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSC-- 787
            |..||::|..:|..:|..|..|...|||....::||||:..:| |:....|:..::|:   .|
  Rat   453 NYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVID-LIEAKMGILELLDE---ECLL 513

  Fly   788 ---QDQDLIMDRVSEKHSQFVKKHTATE--------ISVAHYTGRIIYDTRAFTDINRDFVPPEM 841
               .|::.:    .:.::.||.|::..|        ..:.|:..::.|....|.:.|||.|...:
  Rat   514 PHGTDENWL----QKLYNNFVNKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDML 574

  Fly   842 IETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVN--NLRTL 904
            :|..|:|........|......:.    ||.|:            :...||..:.:.|  :.||.
  Rat   575 VEVLRASKFHLCAAFFQESPVPSS----PFGAM------------ITVKSAKQVIKPNTKHFRTT 623

  Fly   905 AAN-FRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKG 968
            ..| ||.:...|::.|:...   .|:||||:.:.|..|..|.|..:.||::|.|||:|:....:.
  Rat   624 VGNKFRSSLFLLMETLNATT---PHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQS 685

  Fly   969 FSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKMEG--WALGKTKVFLRYYNDEFLAR 1031
            :.||..:.||..||..|....:..:...|:.|:::..||..:.  :..|:||:|.|.....:|.:
  Rat   686 YPSRWTYLEFYSRYGVLMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEK 750

  Fly  1032 LY-----------------ELQVKKVIK-------VQSMMR-------------------ALLAR 1053
            |.                 .||.||.::       :|...|                   |::.:
  Rat   751 LRLDKLRQGCIVIQKHVRGWLQRKKFLRERRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQ 815

  Fly  1054 KRVKG---GKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFA 1115
            |..:|   ..:::|.:       ||...||...|||..|.|...|       |.|:.|..::.:|
  Rat   816 KHCRGYLVRNLYQLIR-------VATITIQAHTRGFLARRRYRKL-------LQEHKAVILQKYA 866

  Fly  1116 KKWREKSIFQ--------VLLHYRAARFQDFVNLSQQVHIYN--------------------QRM 1152
            :.|..:..||        :.|.||..|.|.  .|..|....:                    ||:
  Rat   867 RAWLARRRFQNIRRFVLNIQLTYRVQRLQK--KLEDQNRENHGLVEKLTSLAALRVGDLEKVQRL 929

  Fly  1153 VAGLNK-CTRAVPFERINMR-----EVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSIS 1211
            .|.|.| .|....:|....|     |...|:|......::....|.:|.....|:.:.:..:.::
  Rat   930 EAELEKAATHRHSYEEKGRRYRDSMEERLSKLQKHNAELESQRERAEQSLQERTEELKEKMDQLT 994

  Fly  1212 RQAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKE 1253
            ||.|           |:......||.....|..|...||:||
  Rat   995 RQLF-----------DDVQKEEQQRLLLEKSFELKTQAYEKE 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	193/728 (27%)
Myo5c	XP_006243475.1	MYSc_Myo5	81..741	CDD:276831	187/701 (27%)
		IQ	755..776	CDD:197470	3/20 (15%)
		IQ	831..851	CDD:459869	9/26 (35%)
		SMC_prok_B	<850..>1385	CDD:274008	41/196 (21%)
		Myo5c_CBD	1376..1743	CDD:271260