Protein Alignment ninaC and Tnik

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_063137616.1
• Gene: Tnik / 294917
• RGDID: 1561817
• Length: 1362
• Species: Rattus norvegicus
• Alignment Length: 1355
• Identity: 286/1355 - (21%)
• Similarity: 494/1355 - (36%)
• Gaps: 418/1355 - (30%)

  Fly     9 LPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNL 73
            |.||...||:.|.:..|...:|::.:.:...::.|:|:.....:.:..|::|...|:.|..|.|:
  Rat    18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNI 82

  Fly    74 PEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELN 137
            ..:||.: |.:.|...|::|.|||:|..|:..|::..  .....::||.||||.||..|....|:
  Rat    83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREILRGLSHLH 145

  Fly   138 RNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDI 202
            ::.|:||||:|.|:|||:|..|||.|||:|.|:|.|:|:|.|.||:|.||||||::..|:.:...
  Rat   146 QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATY 210

  Fly   203 TVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNA 267
            ..::|:|:||||.||:|:|.||..||||.||:|.|.|||.|.| :...||::...||...|.||.
  Rat   211 DFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNH 274

  Fly   268 ENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKM 332
            ..||...::::|||:.:. .||.::|..:.:                 .:||...|| .||.|..
  Rat   275 GQRPATEQLMKHPFIRDQ-PNERQVRIQLKD-----------------HIDRTKKKR-GEKDETE 320

  Fly   333 YPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSL-NSNEIKQEFPQEFHAKYRFKSRSE 396
            |  :.:..|...:||  :|       ||..|     :|:| ..:.::::|   ...:...|.|||
  Rat   321 Y--EYSGSEEEEEEN--DS-------GEPSS-----ILNLPGESTLRRDF---LRLQLANKERSE 366

  Fly   397 NQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIK 461
                           .|..::     |..:....:....:||.:.           ..|:|.
  Rat   367 ---------------ALRRQQ-----LEQQQRENEEHKRQLLAER-----------QKRIEE--- 397

  Fly   462 AILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFY 526
                        ..:..|                       .||:
  Rat   398 ------------QKEQRR-----------------------RLEE-------------------- 407

  Fly   527 DFINQQNQLKEYNLKADRNYR--YLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHK 589
                ||.:.||...:.:|..|  |          :.:.||::.....|..:|:  |.|.::...:
  Rat   408 ----QQRREKELRKQQEREQRRHY----------EEQMRREEERRRAEHEQEY--IRRQLEEEQR 456

  Fly   590 QLETVRKVL----AAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKG 650
            |||.:::.|    |.:|..         |..::|......|:...|: .|:.::.||.:....:.
  Rat   457 QLEILQQQLLHEQALLLEY---------KRKQLEEQRQAERLQRQLK-QERDYLVSLQHQRQEQR 511

  Fly   651 GIAERRQYTTEEA--------------------RDARDAVASTLYSRLVD---------FIINRI 686
            .:.::..|..:|.                    |.:..|:...:.:|:.|         |.|:.:
  Rat   512 PLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGV 576

  Fly   687 N----------MNMSFPR--AVFGDTNAII----IHD-----MFGFECFNRNGLEQLMINTLNEQ 730
            .          ::...|:  ||.....|:.    :|:     :.||:       |.|.:.:...:
  Rat   577 QPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQ-------EALNVTSHRVE 634

  Fly   731 MQYHYN-------------QRIFISEMLEMEAEDID------TINL-------NFYDNKTALDNL 769
            |....:             ::...|..|..| |||.      |.::       |...|.:||...
  Rat   635 MPRQNSDPTSENPPLPTRIEKFDRSSWLRQE-EDIPPKVPQRTTSISPALARKNSPGNGSALGPR 698

  Fly   770 L-------TKPD-----------------GLFYIIDDASRSCQDQDLIMDRVSEKHSQF------ 804
            |       :.||                 |     ..:|.|...........|:..||.
  Rat   699 LGSQPIRASNPDLRRTEPVLESSLQRTSSG-----SSSSSSTPSSQPSSQGGSQPGSQAGSSERT 758

  Fly   805 -VKKHTATEIS--VAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMF--------- 857
             |:.::.:|.|  :.|...::      ..:.:||...|....:::.::||.:..:.
  Rat   759 RVRANSKSEGSPVLPHEPSKV------KPEESRDIPRPSRPASYKKAIDEDLTALAKELRELRIE 817

  Fly   858 -TNQ-LTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLS 920
             ||: |.|..:.:...|..:..:|.|....:........:|.:..|....|..:          :
  Rat   818 ETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGK----------N 872

  Fly   921 QNANLGV---HFVRCIRAD-----------------LEYKPRSFHS------------DVVQQQM 953
            :..|:|:   |.:....||                 .|.|.||.||            |:|||..
  Rat   873 EQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSH 937

  Fly   954 KALGV--------------LDTVIARQKGFSSRLPFDEFL--RRYQFLAFDFDEPVEMTKDNCRL 1002
            ...|.              :||......|.|::..|..|:  |.||....|.||  |..:.:...
  Rat   938 SPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDE--EDDESSAAA 1000

  Fly  1003 LFLR--LKMEGWALGKTKVF---------LRYYNDEFLARLYELQVKKVIKVQSMM--------- 1047
            ||..  |:.|...|.:.:..         :|.::|....|.|:.:....|...::.
  Rat  1001 LFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTE 1065

  Fly  1048 RALLARKRVKGGKVFKL-GKKGPEHHDVAAS-KIQKAFRGFRDRVRL-------------PPLVN 1097
            ..|:...|...|||:.| .::..:..||... .:.....|.::::|:             .|.|.
  Rat  1066 NGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1130

  Fly  1098 EKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARFQDF----VNLSQQVHIY 1148
            :|.|                |......:..:||:..:::..    :.|...|.||
  Rat  1131 KKQG----------------WITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	108/273 (40%)
		MYSc_Myo21	346..1022	CDD:276848	139/861 (16%)
Tnik	XP_063137616.1	None