Protein Alignment ninaC and MYO1H

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 1099
• Identity: 260/1099 - (23%)
• Similarity: 455/1099 - (41%)
• Gaps: 246/1099 - (22%)

  Fly   330 EKMYPEDLAALENPVDEN-IIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKS 393
            :|:..:|...|:....|: .:::||.|......|::||.:|:|:|..:....:.......|:..:
Human     9 DKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVN 73

  Fly   394 RSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHL---CYLGDGNRGATGR 455
            ..|..||::::||.||:.|........|::||||.:||:..::.::::.   |.:....:.|..|
Human    74 FFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDR 138

  Fly   456 VESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFH 520
            :..|...:....||.|..|::|:|......:.|...|...|.....|::||.||...:..:.|||
Human   139 LLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFH 203

  Fly   521 IFYYFYDFINQQNQLKEYNLKAD-RNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDI 584
            |||..... .::.:|....|:.| :.|:||........|.:..:.|        ::...|....|
Human   204 IFYQLLAG-GEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKND--------WKTVSNAFSVI 259

  Fly   585 DFNHKQLETVRKVLAAILNIGNIRFRQNGK-YAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMV 648
            ||....||.:..::|::|::|||.|.::.: .|.:.:|..:..||:||.|.....:.:||:
Human   260 DFTEADLENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTH---- 320

  Fly   649 KGGIAERRQYTTEE---------ARDARDAVASTLYSRLVDFIINRIN---MNMSFPR-AVFGDT 700
                 .:.:..|||         :..||||:|..:|.|...:::|:||   :|..|.| .|.|
Human   321 -----RKIEAKTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIG-- 378

  Fly   701 NAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTA 765
                :.|::|||.|::||.||..||..||::|....:|...:|..|.|.|.|:...:.:::||..
Human   379 ----LLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKII 439

  Fly   766 LDNLLTKPDGLFYIID-DASRSCQDQDL-IMDRVSE---KHSQFVKKHTA----------TEISV 815
            .|.:..:..|:..|:| :..|.....|| .::::.|   ||:.|..:..|          .|..:
Human   440 CDLVEERHKGIISILDEECIRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRL 504

  Fly   816 AHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDES 880
            .||.|.:.|.|:.|.:.|.|.:...:.|.                |.|:.|:.:
Human   505 LHYAGEVTYCTKGFLEKNNDLLYRHLKEV----------------LCKSKNIIL----------- 542

  Fly   881 ERKSYALNTLSAGCISQVNNLR---TLAANFRFTCLTLLK-MLSQNANLGVHFVRCIRADLEYKP 941
             |:.:.|        :::.|.|   |:...|:.:..:||: ::|:..:    ::|||:.:...:|
Human   543 -RECFLL--------AELENRRRPPTVGTQFKNSLSSLLETLISKEPS----YIRCIKPNDRKEP 594

  Fly   942 RSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVE------MTKDNC 1000
            ..|...:::.|:|.||:::.:..|:.||:.|..::.||:||  |..:....||      ..||..
Human   595 SKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRY--LGVELSHWVERLMMSLFYKDRY 657

  Fly  1001 RLL---------------------FLRLKMEGWALGKTKVFLRY------YNDEF-------LAR 1031
            :.|                     ::..|.|.:.|||||:|:|:      ..|.|       :||
Human   658 KSLCPDTWPHWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVAR 722

  Fly  1032 L------------YELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFR 1084
            :            |..:.:..||:::..|..||||.::..|             .|...|:|..:
Human   723 IQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRK-------------WAVRIIRKFIK 774

  Fly  1085 GFRDR--------------VR----------LPPLVNEKS-----GQLNENTADFIRPFAKKWRE 1120
            ||..|              ||          ||..|.:||     |.| ||.:|.:|....:...
Human   775 GFISRNKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGIL-ENASDLLRKMCVRNLV 838

  Fly  1121 KSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPF--ERINMREVNSSQLGPLP- 1182
            :...:.:...|.|..|..|..|:............||:     ||  .||:..::|...|..:.
Human   839 QKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQ-----PFVNSRIDEGDINPKVLQLISH 898

  Fly  1183 ------VPIKKMP---FRLDQIPFYDTQ---YMVDPA-----------NSISRQAFPNQLLTQHM 1224
                  ||:.|..   |:..|.....||   |:|:.|           ..:|.....:.:|..|:
Human   899 EKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAKIKQKIEYSALKGVSTSNLSDGILVIHV 963

  Fly  1225 EDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYN--QG---YFRDP 1278
               .|.||. |:..::..|...:.|.       |....:.:.:||.|  ||   :|..|
Human   964 ---SPEDSK-QKGDAVLQCGHVFEAV-------TKLVMLVKKENIVNVVQGSLQFFISP 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	184/740 (25%)
MYO1H	XP_011536525.1	MYSc_Myo1	26..700	CDD:276829	183/739 (25%)
		Adgb_C_mid-like	<696..>763	CDD:412094	15/66 (23%)
		globin helix H	696..720	CDD:412094	5/23 (22%)
		IQ motif	744..762	CDD:412094	7/17 (41%)
		Myosin_TH1	856..1037	CDD:461801	37/172 (22%)