DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo7a

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_006229804.1	Gene:	Myo7a / 266714	RGDID:	628830	Length:	2276	Species:	Rattus norvegicus

Alignment Length:	1301	Identity:	294/1301 - (22%)
Similarity:	533/1301 - (40%)	Gaps:	282/1301 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 ESREPDITVRADVWALGITTIELADGKPPFADMHPTR-AMFQIIRNPPPTLMRPTNWSQQINDFI 259
            |.||.|   |.:.|:..:..|  .||:.|.|....:. |.:.|:.....|...|:::.   .|::
  Rat    15 EGREAD---RLEGWSRRLEGI--MDGQWPLAQGSASAGAWYLILFGYKNTEALPSSYK---GDYV 71

  Fly   260 SESLEKNAE-NRPM--MVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGY 321
            ...|:...| :.|:  ||::.|...: :::::|....                :..|:   :..:
  Rat    72 WMDLKSGQEFDVPIGAMVKLCESGQI-QVVDDEGNEH----------------WISPQ---NATH 116

  Fly   322 VKRFDEKPEKMYP------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQE 380
            :|       .|:|      ||:..|.:..:..|:.:|..|......|::.|.||:::|..::...
  Rat   117 IK-------PMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSI 174

  Fly   381 FPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYL 445
            :..|...:|..|...|..||||::||..|.:|..:...|..::||||.:||:.:.:|:::.|..:
  Rat   175 YSSEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAI 239

  Fly   446 GDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVA 510
            ...:.....:|..:...:....||.|..|::|:|......:.|.|.|.:.||....|:|||.||.
  Rat   240 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVC 304

  Fly   511 TTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYR 575
            .....:.|:|:||...:.:|::.: |:..|....:|.||.:...:          ..||.|:. :
  Rat   305 RQAPDERNYHVFYCMLEGMNEEEK-KKLGLGQAADYNYLAMGNCI----------TCEGRVDS-Q 357

  Fly   576 EFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRFR----QNGKYAEVENTDIVSRIAELLRV 633
            |:.||   ::.:.|...:...:.|:|||||::||:::.    :|....||..:..::..|..|.|
  Rat   358 EYANIRSAMKVLMFTDTENWEILKLLAAILHMGNLQYEARTFENLDACEVLFSPSLATAASHLEV 422

  Fly   634 DEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFP--RAV 696
            :....|..||:..::..|.......:.|:|.|.|||....:|.||..:|:.:||..:..|  :.|
  Rat   423 NPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEV 487

  Fly   697 FGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYD 761
            .....:|.:.|:||||.|..|..|||.||..||.:|..:.:.:|..|..|.:.|.||.:::.|.|
  Rat   488 TNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTD 552

  Fly   762 NKTALDNLLTKPDGLFYIIDDASRSCQDQDLIM-DRVSEKH---SQFV--KKHTATEISVAHYTG 820
            |:.|||.:..:|..:..:||:.|:..:..|..| .:::.:|   :.:|  |....|:..:.|:.|
  Rat   553 NQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAG 617

  Fly   821 RIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSY 885
            .:.|:::.|.:.|||.:..::|:...||.::     |..|:.:|.        |....|:.::|
  Rat   618 IVYYESQGFLEKNRDTLHGDIIQLVHSSRNK-----FVKQIFQAD--------VAMGAETRKRS- 668

  Fly   886 ALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGV---HFVRCIRADLEYKPRSFHSD 947
                            .||::.|:.:...|::      .||.   .|||||:.:...||..|...
  Rat   669 ----------------PTLSSQFKRSLELLMR------TLGACQPFFVRCIKPNEFKKPMLFDRH 711

  Fly   948 VVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL------AFDFD----------EPVEMT 996
            :..:|::..|:::|:..|..|:..|..|.||:.||:.|      |:..|          |.|..|
  Rat   712 LCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLGT 776

  Fly   997 KDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKV 1061
            .|:            |.:||||:||:.::|    .|.|::..|.|..:.::
  Rat   777 HDD------------WQIGKTKIFLKDHHD----MLLEVERDKAITDRVIL-------------- 811

  Fly  1062 FKLGKKGPEHHDVAASKIQKAFRGFRDR---VRLPPLVNEKSGQLNENTADFIRPFAKKWR---- 1119
                             :||..|||:||   :||            ::.|..|:   :.||
  Rat   812 -----------------LQKVIRGFKDRSNFLRL------------KSAATLIQ---RHWRGHHC 844

  Fly  1120 EKSIFQVLLHY-RAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPV 1183
            .|:...:.|.: |.........|.:|..:..||::....:| ||....|
  Rat   845 RKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKFQARC-RAYLVRR---------------- 892

  Fly  1184 PIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDD---EPW---DSPLQRNPSMTS 1242
                        .|....:.|     |:.||:...::.:.:...   |.|   ::...|......
  Rat   893 ------------AFRHRLWAV-----ITVQAYARGMIARRLHRRLRVEYWRRLEAERMRLAEEEK 940

  Fly  1243 CALTYNAYK-KEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQ--MQMNMNAYNNAYNSYNSNY 1304
            .....:|.| ||:|.:.:.:|:.:......:...::.::.||.:  :|....|.:...|  :|:.
  Rat   941 LRKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLQQMERARHEPIN--HSDM 1003

  Fly  1305 NNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPSDPVRELQNM 1369
            .::.:|...:.|.....:|.|       |....:..|......:.:.......|..|
  Rat  1004 VDKMFGFLGTSSGLPGQEGQA-------PSGFEDLERGRREMVEEDVDAALPLPDED-------- 1053

  Fly  1370 ARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDE 1434
               |.|.||     :|.......|.:|:.|::|   .||        ..:.|.|      |.|||
  Rat  1054 ---EEDLSE-----YKFAKFAATYFQGTTTHSY---TRR--------PLKQPLL------YHDDE 1093

  Fly  1435 G 1435
            |
  Rat  1094 G 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	22/89 (25%)
		S_TKc	16..282	CDD:214567	22/89 (25%)
		MYSc	327..1034	CDD:214580	196/746 (26%)
		MYSc_Myo21	346..1022	CDD:276848	188/709 (27%)
Myo7a	XP_006229804.1	MYSc	121..802	CDD:214580	196/744 (26%)
		MYSc_Myo7	140..790	CDD:276832	188/709 (27%)
		IQ	827..848	CDD:197470	7/35 (20%)
		MAP7	<918..996	CDD:283355	13/77 (17%)
		eIF3_subunit	936..>991	CDD:285763	9/54 (17%)
		MyTH4	1078..1314	CDD:214535	10/34 (29%)
		B41	1320..1535	CDD:214604
		FERM_N	1323..>1362	CDD:286467
		FERM_B-lobe	1424..1524	CDD:271216
		FERM_C1_MyoVII	1529..1665	CDD:270019
		SH3_MYO7A	1666..1730	CDD:212814
		MyTH4	1808..1957	CDD:214535
		B41	1964..2176	CDD:214604
		FERM_M	2074..2176	CDD:278785
		FERM_C2_MyoVII	2172..2267	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810