Protein Alignment ninaC and Myo1d

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_037115.2
• Gene: Myo1d / 25485
• RGDID: 621321
• Length: 1006
• Species: Rattus norvegicus
• Alignment Length: 847
• Identity: 214/847 - (25%)
• Similarity: 391/847 - (46%)
• Gaps: 120/847 - (14%)

  Fly   336 DLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPH 400
            |...::.......:.:||.|...|..|:|||::::|:|..::...:.::...:|:.:...|..||
  Rat    13 DFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKVLNIYGRDTIEQYKGRELYERPPH 77

  Fly   401 IFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYL-GDGNRGATGRVESS-IKAI 463
            :|::||.||:.|....:...|::||||.:||:..::.:::::..: ....|....||::. :|:.
  Rat    78 LFAIADAAYKAMKRRSKDTCIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNMLLKSN 142

  Fly   464 LMLV---NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYF 525
            .:|.   ||.|..|::|:|......:.|...|...|...|.|:|||.||......:.:||.||..
  Rat   143 CVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQL 207

  Fly   526 YDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQ 590
            ....::|.....:..|:..:|.|:||     .::||...:|    ...::...:.::.|.|..::
  Rat   208 LQGGSEQMLHSLHLQKSLSSYNYIRV-----GAQLKSSIND----AAEFKVVADAMKVIGFKPEE 263

  Fly   591 LETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAER 655
            ::||.|:|||||::||::|..:|....:||..:||.|||||.........:|....:..|.....
  Rat   264 IQTVYKILAAILHLGNLKFIVDGDTPLIENGKVVSVIAELLSTKADMVEKALLYRTVATGRDIID 328

  Fly   656 RQYTTEEARDARDAVASTLYSRLVDFIINRINMNM---SFPRAVFGDTNAIIIHDMFGFECFNRN 717
            :|:|.:||...|||.|..:|.||..:|:.|||..:   ::...|.|....|.:.|::|||.|:.|
  Rat   329 KQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTVHGKNTVIGVLDIYGFEIFDNN 393

  Fly   718 GLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDD 782
            ..||..||..||::|..:.|.:...|..|.:.|.|...::::::|:..:|.:..:..|:..|:||
  Rat   394 SFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDD 458

  Fly   783 ASRSCQDQDLIMDRV--------SEKHSQFVKKHTAT---------EISVAHYTGRIIYDTRAFT 830
            |   |.:...:.|.:        ..||..|..:.|..         :..:.||.|.::|....|.
  Rat   459 A---CMNVGKVTDGMFLEALNSKLGKHGHFSSRKTCASDKILEFDRDFRIRHYAGDVVYSVIGFI 520

  Fly   831 DINRDFVPPEMIETFRSSLDESIMLMFTNQLTK----AGNLTMPFEAVQHKDESERKSYALNTLS 891
            |.|:|    .:.:.|:     .:|...:|.:.|    .|.|::       .:.::|...|.....
  Rat   521 DKNKD----TLFQDFK-----RLMYNSSNPVLKNMWPEGKLSI-------TEVTKRPLTAATLFK 569

  Fly   892 AGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKAL 956
            ...|:.|:||                     |:...::||||:.:.:..|:.|..:..:.|::.|
  Rat   570 NSMIALVDNL---------------------ASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYL 613

  Fly   957 GVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP---VEMTKDNCRLLFLRLK-MEGWALGKT 1017
            |:|:.|..|:.||:.|..:::||.||:.:: :|..|   :...|:..:.|..|.. .:..|.|||
  Rat   614 GLLENVRVRRAGFAFRQTYEKFLHRYKMIS-EFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKT 677

  Fly  1018 KVFLRYYNDEFLARLYELQVKKVIKV----QSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASK 1078
            |:|:|  ....|..|.||:.:.:::|    |.:.|..|||.|.|..|              ||..
  Rat   678 KIFIR--TPRTLFTLEELRAQMLVRVVLFLQKVWRGTLARMRYKRTK--------------AALT 726

  Fly  1079 IQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAK--KWR---------EKSIFQVLLHYRA 1132
            |.:.:|.::.:..:..:.....|..|      :|.:.|  ||.         |:::..:...:||
  Rat   727 IIRYYRRYKVKSYIHEVARRFHGVKN------MRDYGKHVKWPTPPKVLRRFEEALQSIFNRWRA 785

  Fly  1133 AR 1134
            ::
  Rat   786 SQ 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	186/708 (26%)
Myo1d	NP_037115.2	MYSc_Myo1	24..682	CDD:276829	186/707 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/42 (21%)
		Interaction with calmodulin. /evidence=ECO:0000269|PubMed:8034741	776..896		2/12 (17%)
		Myosin_TH1	803..996	CDD:461801