Protein Alignment ninaC and Myo1e

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_775124.1
• Gene: Myo1e / 25484
• RGDID: 3144
• Length: 1107
• Species: Rattus norvegicus
• Alignment Length: 1242
• Identity: 297/1242 - (23%)
• Similarity: 513/1242 - (41%)
• Gaps: 291/1242 - (23%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            :|:..|....:.:|:|:|:.|.:....:::||.:|:|:|..:....|.::....|:..::.||.|
  Rat    22 DDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPP 86

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            ||:::||..|::|:..:|.|.:::||||.:||:..|:.::.::..:..|     |.....:|.|:
  Rat    87 HIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGG-----GPKVQHVKDII 146

  Fly   465 M--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHI 521
            :        ..||.|..||:|:|....:.:.|...|:..|...:.::|||.||...:..:.:|||
  Rat   147 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHI 211

  Fly   522 FYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDID- 585
            ||...:..:.: |.:...:.:...|.||.:..       .|:.||    ::..|:|:..|..::
  Rat   212 FYQLIEGASPE-QKQSLGITSMDYYYYLSLSG-------SYKVDD----IDDKRDFQETLHAMNV 264

  Fly   586 ---FNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIM 647
               |:.:| ..|.:::|.||::|||.|::.|.||.||:.:.::..|.||.:::.:....||:..|
  Rat   265 IGIFSEEQ-TLVLQIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQM 328

  Fly   648 VK--GGIAERRQYT--TEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDM 708
            ..  ||.:|....|  .|:|...|||:|..|::|:.||:::.||..|......:.    |.:.|:
  Rat   329 DSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYN----IGVLDI 389

  Fly   709 FGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED-----IDTINLNFYDNKTALDN 768
            :|||.|.:||.||..||.:||::     |:|||...|:.|.|:     |....:.:::||...|.
  Rat   390 YGFEIFQKNGFEQFCINFVNEKL-----QQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDL 449

  Fly   769 LLTK--PDGLFYIIDDASRSCQDQDLIMDRVSEKHSQFVKKHTATEIS-------------VAHY 818
            :.:|  |.|:..|:||...:       |..|.|...|.:.:....:|.             :.||
  Rat   450 IESKVNPPGIMSILDDVCAT-------MHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHY 507

  Fly   819 TGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERK 883
            .|::.||...|.:.|||.:..::||..:||....|..:|...|              ..|:..|.
  Rat   508 AGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENL--------------QADKKGRP 558

  Fly   884 SYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDV 948
            :.|.:.:.    .|.|:|.:          ||:|...       |::|||:.:...||:.:....
  Rat   559 TTAGSKIK----KQANDLVS----------TLMKCTP-------HYIRCIKPNETKKPKDWEESR 602

  Fly   949 VQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFL----RLKM 1009
            |:.|::.||:.:.:..|:.|::.|..|.:||:||..|. ....||....:...:|.|    .:..
  Rat   603 VKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILT-KATWPVWRGDEKQGVLHLLQSVNMDS 666

  Fly  1010 EGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDV 1074
            :.:.||::|||::.....||  |.|::.:|                                :|.
  Rat   667 DQFQLGRSKVFIKAPESLFL--LEEMRERK--------------------------------YDG 697

  Fly  1075 AASKIQKAFRGFRDRVRLPP--------LVNEKSGQLNENTADFI------------RPFAKKWR 1119
            .|..|||.:|.|..|.:...        |:|:|..:.|....:||            :.|..| |
  Rat   698 YARVIQKTWRKFVARKKYVQMREDASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGK-R 761

  Fly  1120 EKSIFQVLLHYRAARF----QDFVNLSQQVHIYNQRMV-----AGLNK--CTRAVPFERINMREV 1173
            ||..|..::.....||    :|.:...:.:::..:..|     .||.|  ..|.:..|||
  Rat   762 EKIDFADIVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEVERI----- 821

  Fly  1174 NSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQ---LLTQHMEDDEPWDSPLQ 1235
                   |.|.:..|  :.|....::.:|     :|:....|..:   |||:..|:......||:
  Rat   822 -------LSVSLSTM--QDDIFILHEQEY-----DSLLESVFKTEFLSLLTKRYEEKTQKQLPLK 872

  Fly  1236 RNPSMTSCALTYNAYKKEQACQTNWD--RMGESDNI-YNQGYFRDPQQLRRN----QMQMNMNAY 1293
            .:.::..      ..|||     ||.  ..|.|..: :.|| |.|...|:.:    |:.:.....
  Rat   873 FSNTLEL------KLKKE-----NWGPWSAGGSRQVQFYQG-FGDLAILKPSNKVLQVSIGPGLP 925

  Fly  1294 NNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPP-------------PPPMPSSNYYRNNPN 1345
            .||..:..:..:::.:    ||...|:....|||.||             .||..|.|...|
  Rat   926 KNARPTRRNTVSSRGY----SGGTNNNYPMRAAPAPPGCHRNGLTRNQFVHPPRASGNQRSN--- 983

  Fly  1346 QQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTYDFNNRRGS 1410
                   |:|.|         .:|||        ||.           ||...|         ||
  Rat   984 -------QKSLY---------TSMAR--------PPL-----------PRQQST---------GS 1004

  Fly  1411 DSGDQ-----HTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQRAPTLRQSPASVGRSFE 1470
            |...|     ...:.|...:.|.|.|.......:.|     |...|.:..|.:.|..|......:
  Rat  1005 DRLSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGG-----RPKPQPKPKPQVPQCKALYAYDAQ 1064

  Fly  1471 DSNARSF 1477
            |::..||
  Rat  1065 DTDELSF 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	190/715 (27%)
Myo1e	NP_775124.1	MYSc_Myo1	33..679	CDD:276829	190/715 (27%)
		Actin-binding. /evidence=ECO:0000255	581..591		4/16 (25%)
		Myosin_TH1	719..920	CDD:461801	49/232 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	920..1052		38/187 (20%)
		SH3_MyoIe_If_like	1055..1106	CDD:212761	4/17 (24%)