Protein Alignment ninaC and Myo5b

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_008770307.1
• Gene: Myo5b / 25132
• RGDID: 621347
• Length: 1854
• Species: Rattus norvegicus
• Alignment Length: 1228
• Identity: 282/1228 - (22%)
• Similarity: 508/1228 - (41%)
• Gaps: 230/1228 - (18%)

  Fly   286 IENEDEM-RS--------DIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPE-DLAAL 340
            |.:.||: ||        |..|.|:|..:..|:...| :.|....|. |...|:.:..| ||.||
  Rat    23 IPDPDEVWRSAELTKDYKDGDESLQLRLEDDTILDYP-IDVQNNQVP-FLRNPDILVGENDLTAL 85

  Fly   341 ENPVDENIIESLRHRILMGES---YSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIF 402
            .:..:..::.:|:.|.|  ||   |::.|.:|:::|..|....:.|:....|..::..:..||||
  Rat    86 SHLHEPAVLHNLKVRFL--ESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIF 148

  Fly   403 SVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATG---RVESSIKAIL 464
            :||:.||:.|...::.|.|::||||.:||:.:|:..:::...:| |:...|.   :|.:|...:.
  Rat   149 AVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVG-GSASDTNIEEKVLASSPIME 212

  Fly   465 MLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFI 529
            .:.||.|..|::|:|......:.|.|...:.||....|:|||.||......:.|:||||......
  Rat   213 AIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAA 277

  Fly   530 NQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETV 594
            :.. :.||..|....::.|...........:    ||.| :.|:.|:...:| .:..:|:  .::
  Rat   278 SLP-EFKELALTCAEDFFYTAHGGNTTIEGV----DDAE-DFEKTRQALTLL-GVRESHQ--ISI 333

  Fly   595 RKVLAAILNIGNIRFR--QNGKYAEVENTD-IVSRIAELLRVDEKKF-MWSLTNFIMVKGGIAER 655
            .|::|:||::|::..:  ::|....:...| .:|....||.::..:. .|           :..|
  Rat   334 FKIIASILHLGSVEIQAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHW-----------LCHR 387

  Fly   656 RQYTTEEAR----------DARDAVASTLYSRLVDFIINRIN--MNMSFPRAVFGDTNAIIIHDM 708
            :..||.|..          :||:|:|..:|::|..:|:..||  :..|..:..|     |.:.|:
  Rat   388 KLVTTSETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSF-----IGVLDI 447

  Fly   709 FGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKP 773
            :|||.|..|..||..||..||::|..:|..:|..|..|...|.|....::||||:..:| |:...
  Rat   448 YGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCID-LIEAK 511

  Fly   774 DGLFYIIDDASRSCQ-----DQDLIMDRVSEKHS---QFVK-KHTATEISVAHYTGRIIYDTRAF 829
            .|:..::|:   .|:     ||:. ..::.|:||   .|.| :.:.|...|.|:..::.|.:..|
  Rat   512 LGILDLLDE---ECKVPKGTDQNW-AQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGF 572

  Fly   830 TDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGC 894
            .:.|||.|..|.|...::|                   ..|..|...:|:.:... |.||..:..
  Rat   573 LEKNRDTVYEEQINILKAS-------------------KFPLVADLFRDDKDSVP-ATNTAKSRS 617

  Fly   895 ISQVN--------------NLRTLAANFRFTCLTLLKMLSQNANLGV-HFVRCIRADLEYKPRSF 944
            .|::|              :.:::...||    |.|.:|.:..|... |:||||:.:.|..|..|
  Rat   618 SSKINVRSSRPLMKAPNKEHKKSVGYQFR----TSLNLLMETLNATTPHYVRCIKPNDEKLPFHF 678

  Fly   945 HSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDN-CRLLFLRL- 1007
            ......||::|.|||:|:.....|:.||..:.:|..||:.|....:......|.| |:.:...|
  Rat   679 DPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLI 743

  Fly  1008 -KMEGWALGKTKVFLRYYNDEFLARLYELQVKK-VIKVQSMMRALLAR---KRVKGGKVF----- 1062
             ..:.:..|:||:|.|.....:|.:|...:.:: .|.:|..:|..|.|   :|::...:.
  Rat   744 KDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQRFC 808

  Fly  1063 --KLGKKGPEH--HDVAASKIQKAFRGFRD-----RVRLPPLVNEKSGQ-----------LNENT 1107
              .|.::..||  ...||...||.:|..:.     |||...::.:...:           |.|:.
  Rat   809 RGYLARRLTEHLRRTRAAIVFQKQYRMLKARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHK 873

  Fly  1108 ADFIRPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMRE 1172
            |..|:.:|:.|..:..||                       .||..|.:.:|.    |.|:..|:
  Rat   874 ATIIQKYARGWMARRHFQ-----------------------RQRDAAIVIQCA----FRRLKARQ 911

  Fly  1173 V---------NSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPAN----SISRQAFPNQLLTQHM 1224
            .         ::..|..|.|.::....:|        |..:|..|    ::|.|.  :.:.:.|.
  Rat   912 ALKALKIEARSAEHLKRLNVGMENKVVQL--------QRKIDDQNKEFKTLSEQL--SAVTSTHA 966

  Fly  1225 EDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMN 1289
            .:.|.....|.|.........:....::.|:.:|...:......:....:.|:..:||:....:.
  Rat   967 MEVEKLKKELARYQQNQEADPSLQLQEEVQSLRTELQKAHSERRVLEDTHNRENGELRKRVADLE 1031

  Fly  1290 MNAYNNA-YNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQ 1353
               :.|| ......:.|||.....::.|.::|::                   .|...::...::
  Rat  1032 ---HENALLKDEKEHLNNQILRQSKAESSQSSVE-------------------ENLLIKKELEEE 1074

  Fly  1354 RSSYPPSDPVRE---LQNMARNEGDNSEDP-----PFNFKAMLRKTNYPRGSETNTYD 1403
            ||.|  .:.|:|   |:....|..|..:.|     |.|..::...:|||..|.:...|
  Rat  1075 RSRY--QNLVKEYSQLEQRYENLRDEQQTPGHRKNPSNQSSLESDSNYPSISTSEIGD 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	185/724 (26%)
Myo5b	XP_008770307.1	MYSc_Myo5	91..759	CDD:276831	185/724 (26%)
		IQ	773..795	CDD:197470	5/21 (24%)
		IQ	821..842	CDD:197470	5/20 (25%)
		IQ	871..891	CDD:197470	5/19 (26%)
		SMC_prok_B	906..>1268	CDD:274008	44/259 (17%)
		Myo5b_CBD	1480..1851	CDD:271261