Protein Alignment ninaC and Myo5a

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001423326.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1877
• Species: Rattus norvegicus
• Alignment Length: 1360
• Identity: 287/1360 - (21%)
• Similarity: 514/1360 - (37%)
• Gaps: 336/1360 - (24%)

  Fly   295 DIAEMLELSRDVKTLYKEPELFVDRG----YVKRFDEK----PEKMYPE------DLAALENPVD 345
            ::.:..||.:|.|...|...|.::.|    |  |.|.|    |....|:      ||.||....:
  Rat    20 EVWKSAELLKDYKPGDKVLLLHLEEGKDLEY--RLDPKTSELPHLRNPDILVGENDLTALSYLHE 82

  Fly   346 ENIIESLRHRILMGE-SYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAY 409
            ..::.:||.|.:..: .|::.|.:|:::|..|....:.::....|..::..:..||||:||:.||
  Rat    83 PAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAY 147

  Fly   410 QDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKA----ILMLVNAG 470
            :.|...:..|.|::||||.:||:.:|:..:::...:  ....:...||..:.|    :..:.||.
  Rat   148 KQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATV--SGSASEANVEEKVLASNPIMESIGNAK 210

  Fly   471 TPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQL 535
            |..|::|:|......:.|.|..::.||....|:|||.||......:.|:||||.    :....:|
  Rat   211 TTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQ----LCASAKL 271

  Fly   536 KEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFEN----ILRDIDFNHKQLETVR- 595
            .|:.:        ||:                 ||.:.:...:.    ::..:| :.|::...|
  Rat   272 PEFKM--------LRL-----------------GNADSFHYTKQGGSPMIEGVD-DAKEMAHTRQ 310

  Fly   596 ----------------KVLAAILNIGNIRF--RQNGKYAEVENTDIVSRIAELLRVD-EKKFMWS 641
                            ::||.||::||:.|  |.:.........:.:....:|:.|| |:...|
  Rat   311 ACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHW- 374

  Fly   642 LTNFIMVKGGIAERRQYTTEE----------ARDARDAVASTLYSRLVDFIINRINMNMSFPRAV 696
                      :..|:..|..|          |.:||||:|..:|::|.::|:..:|..:   .:.
  Rat   375 ----------LCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQAL---HSA 426

  Fly   697 FGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYD 761
            ....:.|.:.|::|||.|..|..||..||..||::|..:|..:|..|..|...|.|....::|||
  Rat   427 VKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYD 491

  Fly   762 NKTALDNLLTKPDGLFYIIDDASRSCQDQD-----LIMDRVSEKHSQFVKKHTATE-ISVAHYTG 820
            |:..: ||:....|:..::|:..:..:..|     .:.:....|.:.|.|...:.: ..:.|:..
  Rat   492 NQPCI-NLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFAD 555

  Fly   821 RIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTN--------QLTKAGNLTMPFEAVQHK 877
            ::.|....|.:.|:|.|..|.|:..:||..:.:..:|.:        ..|.:|.  .|...|..|
  Rat   556 KVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGR--TPLTRVPVK 618

  Fly   878 DESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYK-P 941
            ....|......          .:.:|:...||.:...|::.|:...   .|:||||:.: ::| |
  Rat   619 PTKGRPGQTAK----------EHKKTVGLQFRNSLHLLMETLNATT---PHYVRCIKPN-DFKFP 669

  Fly   942 RSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCR--LLF 1004
            .:|......||::|.|||:|:.....||.||..:.||..||:.|....| .:...|..|:  |..
  Rat   670 FTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKD-VLGDRKQTCQNVLEK 733

  Fly  1005 LRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKV-IKVQSMMRALLARKR------------- 1055
            |.|..:.:..||||:|.|.....:|.:|...:::.. |::|..:|..|.|||
  Rat   734 LILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQR 798

  Fly  1056 -VKG------GKVFKLGKKGPEHHDVAASKIQKAFRGF----RDRVRLPPLV------------N 1097
             |:|      .|..:..|        ||:.|||.:|.:    :.::|....:            |
  Rat   799 YVRGYQARCYAKFLRRTK--------AATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLARN 855

  Fly  1098 EKSGQLNENTADFIRPFAKKWREKSIFQVLLHYR---------------------------AARF 1135
            .....|.|:.|..|:...:.|..::      ||:                           .||
  Rat   856 RYRKILREHKAVIIQKRVRGWLART------HYKRTMKAIIYLQCCFRRMMAKRELKKLKIEAR- 913

  Fly  1136 QDFVNLSQQVHI-------YNQRMVAGLNKCTRAV--------------------PFERINMRE- 1172
              .|...:::||       ..||.|...||..:.:                    ..||:.:.|
  Rat   914 --SVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERLQLSEE 976

  Fly  1173 ---VNSSQLGPLPVPIKKMPFRLDQ-------IPFYDTQYMVDPANSISRQAFPNQLLTQHMEDD 1227
               |.:.::..|...|.|:...|:|       |.....:|..:....:|.....|.||.|..|
  Rat   977 EAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETEQLVSNLKEENTLLKQEKE-- 1039

  Fly  1228 EPWDSPLQRNPSMTSCALTYNAYKKEQA---CQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMN 1289
                              |.|....|||   .:|...::.|                ...|::::
  Rat  1040 ------------------TLNHLMVEQAKEMTETMERKLVE----------------ETKQLELD 1070

  Fly  1290 MN----AYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAA----PPPPPPPMPSSNYYRNNPNQ 1346
            :|    .|.|..|.::           |...|.:.||....    .|.|......|.:..|
  Rat  1071 LNDERLRYQNLLNEFS-----------RLEERYDDLKEEMTLMLNVPKPGHKRTDSTHSSN---- 1120

  Fly  1347 QQRNYQQRSSYPPSDPVRELQNMA-RNEGDNSEDPPFNFKAML----RKTNYPRGSETNTYDFNN 1406
                   .|.|..|....|.:::| |.|....:..|.:....|    |.|...:..:....:.:.
  Rat  1121 -------ESEYTFSSEFAETEDIAPRTEEPTEKKVPLDMSLFLKLQKRVTELEQEKQLMQDELDR 1178

  Fly  1407 RR----GSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQRAPTLRQSP 1462
            :.    .|.:.::   :.|::|.....|:..:.....|.|..:..:..:.::|.:.:.:|
  Rat  1179 KEEQVLRSKAKEE---ERPQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAP 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	175/731 (24%)
Myo5a	NP_001423326.1	COG5022	7..1445	CDD:227355	287/1360 (21%)
		MYSc_Myo5	83..751	CDD:276831	175/731 (24%)
		Myo5a_CBD	1503..1877	CDD:271262