DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo16

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_006508841.1	Gene:	Myo16 / 244281	MGIID:	2685951	Length:	1941	Species:	Mus musculus

Alignment Length:	1605	Identity:	361/1605 - (22%)
Similarity:	625/1605 - (38%)	Gaps:	395/1605 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VFRAKELDND-----------------RIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNLPEFY 77
            |||:.|::.|                 |:...:|:.|.|..:|..::|
Mouse    17 VFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKVFQKQE----------------- 64

  Fly    78 GVYKLSKPNGPDEIWF-----------------VMEYCAGG----TAVDMVNKLLKLDRRMREEH 121
            |..|.|||....::.|                 |::....|    |.|.....||.|..|.....
Mouse    65 GPLKRSKPGKRQKVRFGLADMIQDAVIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCARYDNVF 129

  Fly   122 IAYIIRETCRAAIELNRNH--------------------VLHRDIRGDNILLTK-NGRVKLCDFG 165
            ||.::.:.     .:|.||                    ||...:.|.|:.|.. ||.:.| |:.
Mouse   130 IAEVLIDR-----GVNVNHQDEDFWTPMHIACACDNPDIVLLLILAGANVFLQDVNGNIPL-DYA 188

  Fly   166 LSRQVDST-----LGKRGTCIGS--------PCWMAPEVVSAMESREPDITVRADVWALGITTIE 217
            :.....|.     |.::|..:.|        |..|..:|...:.| ..|:..:.|.   |:|.:.
Mouse   189 VEGTESSAILLAYLDEKGVDLSSLRQIKLQRPLSMLTDVRHFLSS-GGDVNEKNDD---GVTLLH 249

  Fly   218 LA-------------------DGKPP--FADMH-------PTRAMFQIIRNPPPTLMRPTNWSQQ 254
            :|                   :|...  :..:|       .|.....:.....|.|:. .|..:.
Mouse   250 MACASGYKEVVLLLLEHGGDLNGTDDRYWTPLHLAAKYGQTTLVKLLLAHQANPHLVN-CNGEKP 313

  Fly   255 INDFISESLEKNAENRPMMVE--MVEHPFLTELIENE-DEMRSDIAEM-LELSRDVKTLYKEPEL 315
            .:...|||:|:......:..|  |.|.|....|.:.| .|:..|:.:: .:||..|..:.|:..|
Mouse   314 SDIAASESIEEMLLKAEIAWEEKMKESPSAPSLAQEELYEILHDLPDLSSKLSPLVLPIAKQDSL 378

  Fly   316 ------FVD--RGYVKRFDE-------------KPEK---MYP---EDLAALENPVDENIIESLR 353
                  |.|  :|..|:..:             |||:   |.|   :|||.|....|.:::..::
Mouse   379 LEKDIMFKDTTKGLCKQESQDGPPETSMTSNCGKPEQVQVMPPAPSDDLATLSELNDSSLLYEIQ 443

  Fly   354 HRILMGESYSFIGDILLSLNSNEIKQEFP------QEFHAKYRFKSRSENQPHIFSVADIAYQDM 412
            .|....:.::|||||.|.:|.   .:|.|      .:.:.....:......||:||.|:.|:..:
Mouse   444 KRFGNDQIHTFIGDIFLLVNP---FKELPIYSTMVSQMYLSPTGQRSPSLPPHLFSCAERAFHRL 505

  Fly   413 LHHKEPQHIVLSGESYSGKSTNARLLIKHL-------CYLGDGNRGATGRVESSIKAILMLVNAG 470
            ...::||:|:||||..|||:..::.::|:|       |.:.|      .|:..:|..:....:|.
Mouse   506 FQERKPQNIILSGERGSGKTQASKQIMKYLTSRASSSCTMFD------SRLRHAIYIVEAFGHAK 564

  Fly   471 TPVNNDSTRCVLQY----CLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQ 531
            |.:||.|: |::||    |....|  .::||..:.|||||.||......|..|.||.:..|.::.
Mouse   565 TTLNNVSS-CLIQYWELQCCQRRK--HITGARISTYMLEKSRVVAQPPGQGTFLIFSWLMDGLSS 626

  Fly   532 QNQ--LKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEG-----NVERYREFENILRDIDFNHK 589
            :.:  |...|..|   :||:.          :..|:|...     |.||....::.|..|.|:..
Mouse   627 EEKCGLHLNNFCA---HRYVS----------QGMREDVSTAEHSLNKERLAALKHALNVIGFSTL 678

  Fly   590 QLETVRKVLAAILNIGNIRFR--QNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIM-VKGG 651
            ::|.:..:|:|||:||:|:|.  .....|.|.:..::.::|.:|:|...:...:||..|. .||.
Mouse   679 EVENLFVILSAILHIGDIQFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGD 743

  Fly   652 IAERRQYTTEEARDARDAVASTLYSRLVDFIINRIN---MNMSFPRAVFGDTNAIIIHDMFGFEC 713
            :..|| :|.:.|...||.:|.:|||||..|:||.:|   .|....:::  .|..|.|.|:||||.
Mouse   744 VIIRR-HTIQMAAFYRDLLAKSLYSRLFGFLINTVNCCLQNQDEYKSL--QTLDIGILDIFGFEE 805

  Fly   714 FNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKT-ALDNLLTKPDGLF 777
            |.:|..|||.:|..||:|.::..:.:|:.|..|...|.:.........|:. .||....||.|.|
Mouse   806 FQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFF 870

  Fly   778 YIIDDASR-----------------SCQDQDLIMDRVSEKHSQFVKKHTATEISVAHYTGRIIYD 825
            .::|:.|:                 ...:.:.:...|.:.:.....|......:|.||.||::|:
Mouse   871 SLLDEESQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTVMHYAGRVMYE 935

  Fly   826 TRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTL 890
            .....:.|:|.:...::...::|.:..|..:|.::|::.|:|...:.:.:.   ...||..|:..
Mouse   936 MGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISSYPSFKF---GGHKSTLLSKR 997

  Fly   891 SAGCISQVNN-----------------LRTLAANFRFTCLT-LLKMLSQ-NANL---GVHFVRCI 933
            :|..:..||.                 |:.|......|..: |.|.|:. .|.|   ..||:.||
Mouse   998 TASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLADITAKLQRGSPHFILCI 1062

  Fly   934 RADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDF--DEPVEMT 996
            :.:....|..|....|..|::.||||..|...:.|:..|..|::||.||:.||...  :...:..
Mouse  1063 KPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPLASVLLGETKGQAA 1127

  Fly   997 KDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKV 1061
            ::.|||:..|.|::||.:|..||||:|::.:.|:.|:....:|::..|.::|..|||:.
Mouse  1128 EERCRLVLQRCKLQGWQIGVHKVFLKYWHVDQLSDLWLQLQRKIVTCQKVIRGFLARQH------ 1186

  Fly  1062 FKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSI--F 1124
                                             |:...|.:..|.|:  |:.|.:...:.::  :
Mouse  1187 ---------------------------------LLQRMSIKQQEVTS--IKSFLQSTEDMALKTY 1216

  Fly  1125 QVLLHYRA---ARFQDFVNLSQQVH--IYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVP 1184
            ..|:...|   ||..|  .|.::||  .:..|...|..:..     ::...|.|:|:.: |:|:.
Mouse  1217 DALVIQNASDIAREHD--RLRKEVHTAYHRNRQEEGTKRAE-----DQGGCRHVHSNSV-PVPMV 1273

  Fly  1185 IKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDD---------EPWDSPLQRNPSM 1240
            :..:           .|.:..|:..      |..|.:....||         :|...| :|:|:.
Mouse  1274 VDSL-----------AQALTGPSTR------PPSLHSVFSMDDSTGLPSPRKQPPPKP-KRDPNT 1320

  Fly  1241 TSCALTYNAYKKEQAC-QTNWDRMGE--------SDNIYNQGYFRDPQQLRRNQMQMNMNAYNNA 1296
            ...|    :|:...|| ....|..||        ||: |:......|::.:|           :.
Mouse  1321 RLSA----SYEAVSACLSAAKDAAGEALTRPRPHSDD-YSTMKKIPPRKPKR-----------SP 1369

  Fly  1297 YNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPSD 1361
            :...:.:| .:.||                     ||.||....:...:|.......:.:.|.|.
Mouse  1370 HTKLSGSY-EEIWG---------------------PPRPSGTMGQGGRHQAPGTLSVQWARPDSV 1412

  Fly  1362 PVRELQ---NMARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTYD 1403
            |....|   ::...:||..:|....:..|:.......||||::.|
Mouse  1413 PQCTPQLPLHLPLPQGDYDDDAEPVYIEMVGNAARAGGSETDSPD 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	66/353 (19%)
		S_TKc	16..282	CDD:214567	66/353 (19%)
		MYSc	327..1034	CDD:214580	212/797 (27%)
		MYSc_Myo21	346..1022	CDD:276848	198/747 (27%)
Myo16	XP_006508841.1	PHA03095	92..>313	CDD:222980	41/231 (18%)
		ANK repeat	114..145	CDD:293786	9/35 (26%)
		ANK repeat	147..178	CDD:293786	5/30 (17%)
		ANK repeat	180..210	CDD:293786	7/30 (23%)
		ANK repeat	243..274	CDD:293786	4/33 (12%)
		ANK repeat	276..307	CDD:293786	4/30 (13%)
		MYSc_Myo16	436..1153	CDD:276844	198/747 (27%)
		NYAP_N	1241..1605	CDD:373845	50/279 (18%)
		NYAP_C	1752..>1782	CDD:373858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25137at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920