DRSC/TRiP Functional Genomics Resources

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Protein Alignment ninaC and TNIK

DIOPT Version :9

Sequence 1:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_055843.1 Gene:TNIK / 23043 HGNCID:30765 Length:1360 Species:Homo sapiens


Alignment Length:405 Identity:136/405 - (33%)
Similarity:212/405 - (52%) Gaps:52/405 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNL 73
            |.||...||:.|.:..|...:|::.:.:...::.|:|:.....:.:..|::|...|:.|..|.|:
Human    18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNI 82

  Fly    74 PEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELN 137
            ..:||.: |.:.|...|::|.|||:|..|:..|::..  .....::||.||||.||..|....|:
Human    83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREILRGLSHLH 145

  Fly   138 RNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDI 202
            ::.|:||||:|.|:|||:|..|||.|||:|.|:|.|:|:|.|.||:|.||||||::..|:.:...
Human   146 QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATY 210

  Fly   203 TVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNA 267
            ..::|:|:||||.||:|:|.||..||||.||:|.|.|||.|.| :...||::...||...|.||.
Human   211 DFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNH 274

  Fly   268 ENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKM 332
            ..||...::::|||:.:. .||.::|..:.:                 .:||...|| .||.|..
Human   275 SQRPATEQLMKHPFIRDQ-PNERQVRIQLKD-----------------HIDRTKKKR-GEKDETE 320

  Fly   333 YPEDLAALENPVDEN-------IIESLRHRILMGESYSFIGDILLSLNSNE-----IKQEFPQEF 385
            |  :.:..|...:||       |:.      |.|||......:.|.|.:.|     .:|:..|: 
Human   321 Y--EYSGSEEEEEENDSGEPSSILN------LPGESTLRRDFLRLQLANKERSEALRRQQLEQQ- 376

  Fly   386 HAKYRFKSRSENQPH 400
                    :.||:.|
Human   377 --------QRENEEH 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 108/273 (40%)
S_TKc 16..282 CDD:214567 105/266 (39%)
MYSc 327..1034 CDD:214580 20/86 (23%)
MYSc_Myo21 346..1022 CDD:276848 15/67 (22%)
TNIKNP_055843.1 STKc_TNIK 18..313 CDD:270807 114/315 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..347 19/89 (21%)
Mediates interaction with NEDD4. /evidence=ECO:0000269|PubMed:20159449 290..1047 27/130 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..440
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..589
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 908..927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 933..998
CNH 1042..1340 CDD:214481
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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