DRSC/TRiP Functional Genomics Resources

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Protein Alignment ninaC and MYO16

DIOPT Version :9

Sequence 1:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:1718 Identity:382/1718 - (22%)
Similarity:656/1718 - (38%) Gaps:416/1718 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 VFRAKELDNDRIVALKI------------------QHYDEEHQVSIEEEY--------------- 61
            |||:.|::.|:.:...:                  .:|:.|.....:|.:               
Human    17 VFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFN 81

  Fly    62 --RTLRDYCDHPNLPEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAY 124
              ..|:|...|.|..|   |.:|.| .|.|....|   .:||:       ||.|..|.....||.
Human    82 LTDMLQDAIIHHNDKE---VLRLLK-EGADPHTLV---SSGGS-------LLHLCARYDNAFIAE 132

  Fly   125 IIRETCRAAIELNRNH--------------------VLHRDIRGDNILLTK-NGRVKLCDFGLSR 168
            |:.:.     .:|.||                    ||...:.|.|:||.. ||.:.| |:.:..
Human   133 ILIDR-----GVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPL-DYAVEG 191

  Fly   169 QVDST-----LGKRGTCIGS--------PCWMA-------------------------------- 188
            ...|:     |.:.|..:.|        |..|.                                
Human   192 TESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGY 256

  Fly   189 PEVVSAMESREPDITVRAD-VWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWS 252
            .||||.:.....|:.:..| .|    |.:.||   ..:...:..:.:.....||     ...|.:
Human   257 KEVVSLILEHGGDLNIVDDQYW----TPLHLA---AKYGQTNLVKLLLMHQANP-----HLVNCN 309

  Fly   253 QQ------INDFISESL--------EKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELS 303
            ::      .::||.|.|        ||..|.........|.|: .|:|.:...:.|.::.::...
Human   310 EEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEPY-EEIIHDLPVLSSKLSPLVLPI 373

  Fly   304 RDVKTLYKEPELFVD--RGYVKRFDE-------------KPE--KMYP----EDLAALENPVDEN 347
            ....:|.::..:|.|  :|..|:..:             |||  |:.|    :|||.|....|.:
Human   374 AKQDSLLEKDIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGS 438

  Fly   348 IIESLRHRILMGESYSFIGDILLSLNSNE---IKQEFPQEFHAKYRFKSRSENQPHIFSVADIAY 409
            ::..::.|....:.|:|||||||.:|..:   |......:.:.....|..|...||:||..:.|:
Human   439 LLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAF 503

  Fly   410 QDMLHHKEPQHIVLSGESYSGKSTNARLLIKHL-CYLGDGNRGATGRVESSIKAILMLVNA---G 470
            ..:...:.||..:||||..||||..::.:|:|| |..|    .:...::|..|.::.::.|   .
Human   504 HQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAG----ASRATLDSRFKHVVCILEAFGHA 564

  Fly   471 TPVNNDSTRCV-----LQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFIN 530
            ....||.:.|.     ||:|   .:..:::||....|:|||.|:.:....|.||.|||...|.::
Human   565 KTTLNDLSSCFIKYFELQFC---ERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLS 626

  Fly   531 QQNQLKEYNLKADR--NYRYLRVPPEVPPSKLKYRRDDPEG-----NVERYREFENILRDIDFNH 588
            .:   ::|.|..:.  .:|||.          :..:||...     |.|:....:..|..:.|:.
Human   627 AE---EKYGLHLNNLCAHRYLN----------QTIQDDASTGERSLNREKLAVLKRALNVVGFSS 678

  Fly   589 KQLETVRKVLAAILNIGNIRFR--QNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGG 651
            .::|.:..:|||||::|:|||.  ..|..|.|.:..::.::|.:|:|...:...:||..|....|
Human   679 LEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKG 743

  Fly   652 IAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNM-SFPRAVFGDTNAIIIHDMFGFECFN 715
            ....|::|.:.|...||.:|.:|||||..|::|.:|..: |........|..|.|.|:||||.|.
Human   744 DMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQ 808

  Fly   716 RNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKT-ALDNLLTKPDGLFYI 779
            :|..|||.:|..||:|.::.|:.:|:.|.:|...|.:.........|:. .||....||.|...:
Human   809 KNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTL 873

  Fly   780 IDDASR-----------------SCQDQDLIMDRVSEKHSQFVKKHTATEISVAHYTGRIIYDTR 827
            :|:.|:                 ...:.:.:...:.:.:.....|...|..::.||.||::||..
Human   874 LDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVV 938

  Fly   828 AFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQ---HKDE---------- 879
            ...:.|:|.:...::...::|.:..|..:|.::|::.|:|...:.:.:   ||..          
Human   939 GAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASS 1003

  Fly   880 --SERKSY-ALNTL--SAGCISQVNNLR-----TLAANFRFTCLTLLKMLSQNANLGVHFVRCIR 934
              .|.|:| .|:.|  ..|..:.:..|.     |:|:..|   .:|:.::.:......||:.|||
Human  1004 IIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLR---KSLMDIIGKLQKCTPHFIHCIR 1065

  Fly   935 ADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDF--DEPVEMTK 997
            .:....|.:|.:..|..|::.:|||:.|...:.|:..||.|.:||.||:.||..|  ::..:...
Human  1066 PNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAA 1130

  Fly   998 DNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARL-YELQVKKVIKVQSMMRALLARKRVKGGKV 1061
            :.|||:..:.|::||.:|..||||:|::.:.|..| .:|| :|:|..|.::|..|||:.:     
Human  1131 ERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQ-RKIITCQKVIRGFLARQHL----- 1189

  Fly  1062 FKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQV 1126
                             :|      |..:|...:.:..|  ..:||.|               ..
Human  1190 -----------------LQ------RISIRQQEVTSINS--FLQNTED---------------MG 1214

  Fly  1127 LLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFR 1191
            |..|.|...|:..:::::    |.|:.:.:|........|..||:|..|.:......|....|..
Human  1215 LKTYDALVIQNASDIARE----NDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSS 1275

  Fly  1192 LDQIPFYD--TQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQRNPSM------TSCALTYN 1248
            :......|  .|.:|.|  ||..   |:......|:|.....||.::.|..      |..:.:|.
Human  1276 MSVCAAVDGLGQCLVGP--SIWS---PSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYE 1335

  Fly  1249 AYK------KEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQ 1307
            |..      :|.|.:........||: |:......|::.:|:.......:|...           
Human  1336 AVSACLSAAREAANEALARPRPHSDD-YSTMKKIPPRKPKRSPNTKLSGSYEEI----------- 1388

  Fly  1308 NWGVHRSGSRRNSLKGYAAP----------------PPPPPPMPSSN----YYR--------NNP 1344
                  ||||....:...||                ||..||....:    |..        ::|
Human  1389 ------SGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSP 1447

  Fly  1345 NQQQRNYQQRSSYPPSD---------------PVRELQNMARNE-----GDNSEDPPFNFKAMLR 1389
            :..:..|::.....|.|               |:  |.....:|     ||..:.|| .|..:| 
Human  1448 DPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPL--LHRAPEDEAAGPPGDACDIPP-PFPNLL- 1508

  Fly  1390 KTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPKLR-----STGRRYQ-DDEGYNSSSGNYGVSRK 1448
                |.......:.......|.:.|:....|.:::     .|..:|. ..||.:..|..|..|:|
Human  1509 ----PHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQK 1569

  Fly  1449 FGQQQRAPTLRQSPASVGRSFEDSNARS 1476
             |...|       |||.|.:..:.:.|:
Human  1570 -GDGDR-------PASPGLALFNGSGRA 1589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 69/367 (19%)
S_TKc 16..282 CDD:214567 69/367 (19%)
MYSc 327..1034 CDD:214580 209/791 (26%)
MYSc_Myo21 346..1022 CDD:276848 195/740 (26%)
MYO16NP_001185879.1 ANKYR 81..332 CDD:223738 56/282 (20%)
ANK repeat 86..112 CDD:293786 10/29 (34%)
ANK 89..190 CDD:238125 31/120 (26%)
ANK repeat 114..145 CDD:293786 12/42 (29%)
ANK 142..297 CDD:238125 28/162 (17%)
ANK repeat 147..178 CDD:293786 6/30 (20%)
ANK repeat 180..210 CDD:293786 7/30 (23%)
ANK repeat 243..274 CDD:293786 5/30 (17%)
ANK repeat 276..307 CDD:293786 6/42 (14%)
ANK repeat 309..335 CDD:293786 4/25 (16%)
MYSc 426..1165 CDD:214580 203/761 (27%)
MYSc_Myo16 437..1155 CDD:276844 195/740 (26%)
NYAP_N 1253..1590 CDD:292079 72/376 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D25137at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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