Protein Alignment ninaC and MYH15

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Alignment Length: 974
• Identity: 242/974 - (24%)
• Similarity: 422/974 - (43%)
• Gaps: 149/974 - (15%)

  Fly   202 ITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLM--RPTNWSQQINDFISESLE 264
            :|.||..|.:.:..::|:|.....|.:..:.|...:::   .|.:  :...|.....:...|:..
Human     7 LTFRAFFWWIALIKMDLSDLGEAAAFLRRSEAELLLLQ---ATALDGKKKCWIPDGENAYIEAEV 68

  Fly   265 KNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKP 329
            |.:|:..           |.::|..|      .|.|.:..| |.....|               |
Human    69 KGSEDDG-----------TVIVETAD------GESLSIKED-KIQQMNP---------------P 100

  Fly   330 EKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSR 394
            |....||:|.|.:..:.:::.:|:.|......|::.|...:::|..:....:.:|..|.|:.|.|
Human   101 EFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRR 165

  Fly   395 SENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGD--GNRGATGRVE 457
            ||..||||:||:.|:|||||::|.|.|:.:|||.:||:.|::.:|::...:..  .:|...|.:|
Human   166 SEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGALE 230

  Fly   458 SSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHN 518
            ..|.....::    ||.|..|::|:|......:.||..|.:|....::|:|||.||......:.|
Human   231 DQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERN 295

  Fly   519 FHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKY---------RRDDPEG--NVE 572
            :||   ||..::.|.:|.:..|.:            ..||...:         ..||.|.  ..|
Human   296 YHI---FYQILSGQKELHDLLLVS------------ANPSDFHFCSCGAVTVESLDDAEELLATE 345

  Fly   573 RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGK--YAEVENTDIVSRIAELLRVDE 635
            :..:....|.|..:.      ..|:..||::.||::|:|..:  ..|.:.|:...:.|.|:.::.
Human   346 QAMDILGFLPDEKYG------CYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINS 404

  Fly   636 KKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRIN--MNMSFPRAVFG 698
            .:.:..|.:..:..|.....|..|.|:...|..|::.::|.|:..:::.|||  ::....|..|
Human   405 SELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFF- 468

  Fly   699 DTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNK 763
                |.|.|:.|||....|.||||.||..||::|..:|..:|:.|..|.:.|.|:.:::.|..:.
Human   469 ----IGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDL 529

  Fly   764 TALDNLLTKPDGLFYIIDDASRSCQDQDL-----IMDRVSEK--HSQFV---KKHTATEISVAHY 818
            .|..:|:.||.|:..|:::.....:..||     :.|....|  |.|..   ||.......:.||
Human   530 QACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHY 594

  Fly   819 TGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERK 883
            .|.:.|:...:.:.|:|.:...::..|:.|.:..:..:|.|.::.  :..:||     .::..:|
Human   595 AGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMST--DSAIPF-----GEKKRKK 652

  Fly   884 SYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDV 948
            ..:..|:::   ....||..|..|.:.|              ..||||||..::...|......:
Human   653 GASFQTVAS---LHKENLNKLMTNLKST--------------APHFVRCINPNVNKIPGILDPYL 700

  Fly   949 VQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL---AFDFDEPVEMTKDNCRLL-FLRLKM 1009
            |.||::..|||:.....::||.:||.:.:|.:||..|   .|...:.|...|....|| .|.:..
Human   701 VLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDH 765

  Fly  1010 EGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARK--RVKGGKVFKLGKKGPEHH 1072
            ..:..|.||||   :...||.:|..::.:::.||.::.:|....|  |:|..|:.       |..
Human   766 TQYRFGITKVF---FKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKIL-------EER 820

  Fly  1073 DVAASKIQKAFRGF---------RDRVRLPPLVNEKSGQLNENTADFIRPFA--KKWREKSIFQ 1125
            | |...||...|.|         |...::.|||  ||.::.|..|......|  :|..|||.||
Human   821 D-ALILIQWNIRAFMAVKNWPWMRLFFKIKPLV--KSSEVGEEVAGLKEECAQLQKALEKSEFQ 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	13/81 (16%)
		MYSc_Myo21	346..1022	CDD:276848	183/710 (26%)
MYH15	XP_011510861.1	COG5022	53..1460	CDD:227355	233/925 (25%)
		MYSc_Myh15_mammals	117..778	CDD:276892	183/713 (26%)
		SMC_prok_B	1093..1932	CDD:274008