Protein Alignment ninaC and Myo15b

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001371162.1
• Gene: Myo15b / 217328
• MGIID: 2685534
• Length: 3069
• Species: Mus musculus
• Alignment Length: 1236
• Identity: 295/1236 - (23%)
• Similarity: 485/1236 - (39%)
• Gaps: 265/1236 - (21%)

  Fly   171 DSTLGKRGTCIGSPCWMAPEVVSAMESREPDITVRADVWALGITTI--------ELADGKPPFAD 227
            :|.....||..|:|      ...|.|.||     ..:....|:...        ...:|.||
Mouse   517 ESGSSSSGTSAGAP------TAGAAEDRE-----EQEANGEGVARACQVPSFFPSARNGTPP--- 567

  Fly   228 MHPTRAMFQIIRNPPPTLMRPT--NWSQQINDFISESLEKNA---------ENRPMMVEMVEHPF 281
             :..|:..:     |.||...|  :|:|..|.  ||..|..|         |.|.........|
Mouse   568 -NENRSQAE-----PETLEAKTGVHWAQDSNP--SEDPELGADTLLPQLTLETRLRQNSPCRSP- 623

  Fly   282 LTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYP-EDLAALENPVD 345
             .|..|.||:..:.:...||||.. :.|...|.|....|.:      ||.:.. ||||.|....|
Mouse   624 -RERWEPEDDTEAALERDLELSLQ-RNLEMPPFLGAKTGSL------PESLEDIEDLARLRLVCD 680

  Fly   346 ENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQ 410
            .:::..|:.|..:|..|:|.|.:||:||.:.....|..|..|.|..:......||||::...||.
Mouse   681 SSVLLCLKKRFHLGRIYTFGGPLLLALNPHRSLPLFSSEVLASYHPRKAPNTTPHIFAIGAAAYS 745

  Fly   411 DMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGAT-GRVESSIKAILMLVNAGTPVN 474
            ......:...|:|.|.|.|||:..|:.:::.|..||.....|. .::|..:..:....:|.|.:|
Mouse   746 LSQSTGQDSCILLGGHSGSGKTEGAKKILEFLSSLGQKPMEANLAQLEDILPVLGSFGHAKTILN 810

  Fly   475 NDSTRC--VLQYCLTFGKTGKMSGAVFNMYMLE------------------KLRVATTDG----- 514
            .:::|.  .::.||   :.|.:.||..:.|:||                  .|:|....|
Mouse   811 ANASRFGQEIRLCL---QQGLIVGASVSHYLLETSRVVFQVMTSLLPTPSPALKVGKRTGHSPQA 872

  Fly   515 -------------TQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDD 566
                         .:.:||:||.....:: ..:.::.:|:....|.||.   :....:|:.:.|
Mouse   873 LLPTKPVSLPKAQAERSFHVFYELLAGLD-PTEREQLSLQGPEAYYYLN---QGGACRLQGKED- 932

  Fly   567 PEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF----RQNGKYAEVENTDIVSRI 627
                .:.::|....||.:....::|..|..|||.||::|||.|    |::.:.|.|.:...:...
Mouse   933 ----AQDFKELMKALRGLGLCAEELTAVWAVLATILHLGNICFSSSERESQEVAAVSSWAEIHLA 993

  Fly   628 AELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSF 692
            |.||:|..::...::|..:|........|....|.|.|||||:|.|||:||..:::..||..:|.
Mouse   994 ARLLQVPPERLEGAVTKRVMDTPYGPVSRPLPVEGAIDARDALAKTLYTRLFTWLLKHINARLSP 1058

  Fly   693 PRAVFGDTNA-IIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTIN 756
            ||.  .|:.| |.:.|.||||....||||||..|..:|::|...:|::...|....:.|.:..:.
Mouse  1059 PRE--ADSVATIAVVDAFGFEALRVNGLEQLCSNLASERLQLFSSQKLLAQEEEVCQQELLKWVP 1121

  Fly   757 LNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSEK-------HSQFVKKHTATEI- 813
            :.....::.||.|:.:|..|..|:|..:...|..|   ....:|       |..:.|......|
Mouse  1122 IPQPPRQSCLDLLVGQPHSLLNILDTQTWLSQATD---HTFLQKCHYHHGDHPSYAKPQLPLPIF 1183

  Fly   814 SVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKD 878
            :|.||.|.:.|....|.:.||..:.|.::|..|.|           ||...|:|   |:..:.:.
Mouse  1184 TVRHYAGTVTYQVHKFINRNRGHLDPAVLEMLRQS-----------QLQLMGSL---FQEAEPQA 1234

  Fly   879 ESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLG---VHFVRCIRADLEYK 940
            .:|:                 |..|||:.|:.|...||      |.||   |:.:.|:.......
Mouse  1235 GTEQ-----------------NKPTLASRFQQTLGDLL------ARLGRGHVYVIHCLNPTPGKI 1276

  Fly   941 PRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLF- 1004
            |.......|.:|::..|:|:.:..|...|..|:.|..||.|:..|. ...:.....::.|..:.
Mouse  1277 PGLLDVGHVAEQLRQAGILEIIGTRSTHFPVRVSFQVFLARFHALG-SGRQKAASDQERCGAILS 1340

  Fly  1005 --LRLKMEGWALGKTKVFLRYYNDEFLARLY-ELQVKKVIKVQSMMRALLARKRVKGGKVFKLGK 1066
              |..:...:.||.|:|.|:....:.|.:|: :.:.:.::.:...:||.:.|:|::
Mouse  1341 EVLGAESPLYHLGVTQVLLQEQGWQQLEQLWAQRRSQALLTLHRGLRACITRQRLR--------- 1396

  Fly  1067 KGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKS--GQLNENTADFI-RPFAKKWREKSIFQVLL 1128
                    ...::|...||.:.|.|   .:..:|  |||  ||...: ||..:: |:|  .::|.
Mouse  1397 --------LLPRMQARVRGLQARKR---YLQRRSALGQL--NTILLVARPLLRR-RQK--LRLLS 1445

  Fly  1129 HYRAA------RFQDFVNLSQQVHIY--------NQRMVAGLNKCTRAVPFERINMREVNSSQLG 1179
            ...||      |..|...|.....:.        :|.::.|  ..|.::|.|
Mouse  1446 WGWAASEALETRPSDLGRLEIPAQLATLLERAEGHQALLTG--SITESLPPE------------- 1495

  Fly  1180 PLPV-PIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQR----NPS 1239
             :|. |...:|..:||.||          :|....:|....|.:   ..:|.|.||.|    ||.
Mouse  1496 -VPARPSLTLPPDIDQFPF----------SSFVSTSFQKPFLPR---PGQPLDEPLTRLDGENPQ 1546

  Fly  1240 MTSCALTYNAYK------------KEQA-----CQTNWDRMGESDNIYNQ---GYFRDPQQLRRN 1284
            .   ||..|...            :||.     .|....|.|..|.:::|   ..:|:|.: ::|
Mouse  1547 Q---ALEINRVMLRLLGEGSLQSWQEQTMGTFLVQQAQRRPGLRDELFSQLVAQLWRNPDE-QQN 1607

  Fly  1285 Q 1285
            |
Mouse  1608 Q 1608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	28/129 (22%)
		MYSc_Myo21	346..1022	CDD:276848	183/733 (25%)
Myo15b	NP_001371162.1	PTZ00449	<185..>326	CDD:185628
		MYSc_Myo35	681..1360	CDD:276861	183/733 (25%)
		MyTH4	1575..1677	CDD:459939	9/35 (26%)
		SH3	2469..2523	CDD:473055
		MyTH4	2617..2763	CDD:470587
		FERM_M	2853..2968	CDD:459788
		PH-like	2964..3064	CDD:473070