Protein Alignment ninaC and hum-2

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001317742.1
• Gene: hum-2 / 179321
• WormBaseID: WBGene00002036
• Length: 1811
• Species: Caenorhabditis elegans
• Alignment Length: 1176
• Identity: 283/1176 - (24%)
• Similarity: 496/1176 - (42%)
• Gaps: 273/1176 - (23%)

  Fly   322 VKRFDEKPEKMYP------EDLAALENPVDENIIESLRHRILMGES-YSFIGDILLSLNS-NEIK 378
            :|..|:.|....|      :||..|....:..::.:|:.|.:.|.| |::.|.:|:::|. .:..
 Worm    63 IKSLDQLPFLRNPAFLVGKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCS 127

  Fly   379 QEFPQEFHAKYR--FKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKH 441
            ..:.:|....||  .||..|..||||:||:.|:.||....:.|.|::||||.:||:.:|:.::::
 Worm   128 HIYGEEIIQVYRGAGKSAREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRY 192

  Fly   442 LCYLGDG---NRGAT---GRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTG-KMSGAVF 499
            |..:...   |.|.|   .||.:|...:..:.||.|..|::|:|......:.|.:.| ::.||..
 Worm   193 LASVAASKTRNGGTTSIEARVLASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEM 257

  Fly   500 NMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYL------RVPPEVPPS 558
            ..|:|||.|:......:.|:||||......|.| .||:.:|....:|.||      |:|
 Worm   258 KTYLLEKSRLVFQAPGERNYHIFYQLCAARNHQ-VLKDLHLGPCESYSYLTQGGDSRIP------ 315

  Fly   559 KLKYRRDDPEGNVERYREFENILRDID---FNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVEN 620
                       .|:...:||.:|:.:.   |:.||:..|.::||.:|.:||:.| :||:.:...:
 Worm   316 -----------GVDDKADFEALLKALQLLGFDEKQMSDVFRLLAGLLLLGNVHF-ENGEGSSAVS 368

  Fly   621 TDIVSRIAELLR----VDEKKF-MWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVD 680
            ......|:.|.|    :.|... :|.....|.....|. .:..|..||..:|||:...|||.|..
 Worm   369 ASSCQEISRLCREFWKISESDLRIWLTRREIRAVNEIV-TKPLTKNEAVRSRDALTKMLYSHLFG 432

  Fly   681 FIINRINMNMSFPRAVFGDTNA-------IIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQR 738
            :::::||..::....:.| ||.       |.:.|::|||.|:.|..||..||..||::|..:||.
 Worm   433 WLVDKINEALNEKDKLDG-TNQKKRPDRFIGVLDIYGFETFDVNSFEQFSINYANEKLQQQFNQH 496

  Fly   739 IFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSE-KHS 802
            :|..|..|...|:|:.:.::|:||:.|:| |:..|.|:..::|:..:.....|  .|.:|: ::|
 Worm   497 VFKLEQEEYIREEIEWVRVDFHDNQPAID-LIEGPVGMINLLDEQCKRLNGSD--ADWLSQLQNS 558

  Fly   803 QFVKKH--------TATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTN 859
            ..:|::        .:.:..|.|:...:.|.|..|.:.|||.:..::       ||..:...|..
 Worm   559 TELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGFVEKNRDAIGEQL-------LDVVVASKFPF 616

  Fly   860 QLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTL----AANFRFTCLTLLKMLS 920
            ..|..|                  |.|..::|:...|.....||:    |:.||.:...|:.:|
 Worm   617 IRTVIG------------------STAPTSVSSSSSSSTPGKRTIKKTVASQFRDSLKELMSVL- 662

  Fly   921 QNANLGVHFVRCIRAD-----LEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLR 980
              .:...|:||||:.:     .:::|:.     ..||::|.|||:||.....||.||.|::||.|
 Worm   663 --CSTRPHYVRCIKPNDSKISFDFEPKR-----AIQQLRACGVLETVRISAAGFPSRYPYEEFAR 720

  Fly   981 RYQFL-----AFDFDEPVEMTKDNCRLLFLRLKMEG-WALGKTKVFLRYYN-------------- 1025
            ||:.:     |...|:|.:..:..|:    :...|| :|:||||:|||...
 Worm   721 RYRVIYTKEAALWRDKPKQFAELACQ----QCLEEGKYAVGKTKIFLRTGQVAVLERVRLDTLAA 781

  Fly  1026 ---------DEFLA-RLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQ 1080
                     ..||| |.||...:.::.||:.::|.||.:|:|..::.:           |...:|
 Worm   782 AATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIKYLQMHR-----------AVIVMQ 835

  Fly  1081 KAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWR-EKSIFQVLLHYRA--ARFQDFVNLS 1142
            .|.||:.:|.:...:.:...|......|:.:|.:.:|.| |||...:...:|.  ||.:...|..
 Worm   836 SAVRGYLERRKYEQIRDSIIGIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARREQIANRK 900

  Fly  1143 QQVHI------------------------YNQRMVAGL-NKC----------------------- 1159
            :.|.:                        :.|::..|| ||.
 Worm   901 KVVMVQCAVRKWLAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFAT 965

  Fly  1160 -------TRA----VPFERINMRE--------------------VNSSQLGPLPVPIKKMPFRLD 1193
                   |:|    :..||:.:.|                    :..:|.|.:...:.::..|||
 Worm   966 ASKNLQKTKADLAMMEAERLTLLEARNRVEVLQEEVERLETECDLKEAQRGGMETKMVELQSRLD 1030

  Fly  1194 QIPFYDTQYMVDPANSISRQAFPNQLLTQHME----DDEPWDSPLQR-NPSMTSCALTYNAYKKE 1253
            |.     |...:...:|..       ||:.:|    |...||...|| ..::.:.....||...|
 Worm  1031 QF-----QMQSESGQTIVE-------LTEQLEKAKADRVLWDEERQRMEAALNTERSARNALDAE 1083

  Fly  1254 QACQTNWDRMGESDNIYNQGYFRDPQQLRRN-------QMQMNMNAYNNAYNSYNSNYNNQNWGV 1311
            .|...  :::.::.:::....|:.....::|       :...|::....::.:...|      ||
 Worm  1084 MAAMR--EQLMKNVDLFESSTFQKRPSQKKNRDDDSCSRTTSNLSQLTGSFTAETIN------GV 1140

  Fly  1312 HRSGSR 1317
            | |.||
 Worm  1141 H-STSR 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	202/731 (28%)
hum-2	NP_001317742.1	MYSc_Myo5	93..764	CDD:276831	202/731 (28%)
		IQ	779..799	CDD:197470	4/19 (21%)
		IQ	826..847	CDD:197470	6/31 (19%)
		CCDC158	<864..1473	CDD:464943	51/303 (17%)
		Myo5_CBD	1429..1803	CDD:271254