DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo7b

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_115770.2	Gene:	Myo7b / 17922	MGIID:	107709	Length:	2113	Species:	Mus musculus

Alignment Length:	1371	Identity:	301/1371 - (21%)
Similarity:	520/1371 - (37%)	Gaps:	343/1371 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 KTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGE----------- 360
            |||.::     |.|       |...::.|||:.| .|:..|..:.:...|.:|:
Mouse    35 KTLIED-----DEG-------KEHWVHAEDLSTL-RPMHPNSAQGVDDMIRLGDLNEAGVVHNLL 86

  Fly   361 -------SYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEP 418
                   .|::.|.||:::|..::...:..|....|..:...|..||||::|:..|.:|..:|..
Mouse    87 IRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRD 151

  Fly   419 QHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQ 483
            |..::||||.:||:...:|:::.|..:...:.....:|..:...:....||.|..|::|:|....
Mouse   152 QCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKY 216

  Fly   484 YCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFY-YFYDFINQQNQLKEYNLKADRNYR 547
            ..:.|..:|.:.||....::|||.||......:.|:|||| .......::.|:....:.::  |.
Mouse   217 IDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLSLGMPSE--YH 279

  Fly   548 YLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQN 612
            ||.:........|...:|        |....:.::.:.|:..:...:.|:|||||::||:.| ..
Mouse   280 YLTMGSCTSSEGLSDAKD--------YAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGF-MA 335

  Fly   613 GKYAEVENTDIVSRIA-----ELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVAS 672
            ..:..::::|::...|     :||.|..:.....|....:...|....|.....:|.|.|||...
Mouse   336 AVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQATDRRDAFVK 400

  Fly   673 TLYSRLVDFIINRINMNMSFPRAVFGDT--NAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHY 735
            .:|.||..:|:.:||..:..|:|.....  .||.:.|:||||.|..|..|||.||..||.:|..:
Mouse   401 GIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINFANEHLQQFF 465

  Fly   736 NQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIM----DR 796
            .:.:|..|..|..:|:|....:::.||:..||.|..||..:..::|:.||..|..|:.|    :.
Mouse   466 VKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGTDVTMLQKLNS 530

  Fly   797 VSEKHSQFVKKHTA--TEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTN 859
            :...:..|:...:.  |...:||:.|.:.|....|.:.|||.:..:::....||.::.:..:|
Mouse   531 IHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKNKFLKEIF-- 593

  Fly   860 QLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQV----------NNLR---TLAANFRFT 911
                            :.|.|:.|      |..|.|.||          ::::   |||:.|:.:
Mouse   594 ----------------NVDSSQTK------LGHGTICQVKAGSQLFKSSDSIKRPVTLASQFKQS 636

  Fly   912 CLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFD 976
            ...|:::|:   |...:|||||:.:...||..|..::..||::..|:::||..|:.||..|..||
Mouse   637 LDQLMRILT---NCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFD 698

  Fly   977 EFLRRYQFL-----AFDF-DEPVEMT-----------KDNCRLLFLRLKMEGWALGKTKVFLRYY 1024
            ||.:|::.|     ...| ::|.:||           ||             |.:||||:||:.:
Mouse   699 EFSQRFRVLLPSPERMQFQNKPRQMTLHIADLCLGTDKD-------------WKVGKTKIFLKDH 750

  Fly  1025 NDEFLARLYELQVKK-------VIKVQSMMRALLARKR----------VKGG-------KVFKLG 1065
            .|..      |::::       .|::|.::|....||.          ::.|       |.|||.
Mouse   751 QDTV------LEIRRSQALDGAAIRIQRVLRGHKYRKEFLRQRRAAVTLQAGWRGYSQRKNFKLI 809

  Fly  1066 KKGPEHHDVAASK--IQKAFRGFRDRV-----RLPPLVNEKSGQLNENTADFIRPFAK------- 1116
            ..|.|.....|..  :.:.|:..|.|:     |....:..:..|........|:..|:
Mouse   810 LVGFERLQAIARSHLLMRQFQAMRQRIVQLQARCRGYLVRQQVQAKRRAVVIIQAHARGMVVRKS 874

  Fly  1117 KWREKSI-----------FQVLLHYRAAR-FQDFVN---LSQQVHIYNQRMVAGLNKCTRAVPFE 1166
            .|::||.           .||.:|.|..: ..|.|.   :.::|..:...|:.|
Mouse   875 YWQQKSTGPQVILAKEPKAQVAVHERKRKSIYDTVTDTAMVEKVFGFLPAMIGG----------- 928

  Fly  1167 RINMREVNSSQLGPLPVPIKKMPFR--------LDQIPFYDTQYMVDP---ANSISRQAFPNQLL 1220
                      |.||.|...:.:..:        ||.:|.     |..|   .:|::...||...:
Mouse   929 ----------QEGPAPTRFEDLEVKTQKLHEVDLDTVPM-----MAMPEEEVDSLAEYTFPKFAV 978

  Fly  1221 T------QHMEDDEPWDSPL--QRNPSMTSCALTY-------------------NAYKKEQACQT 1258
            |      .|....:|...||  ..|.:..|.||..                   |:.......:.
Mouse   979 TYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIIILRFMGDLPEPVVYGRNSLTGSSVMRQ 1043

  Fly  1259 NWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAY-------NSYNSNYNNQNWGVHRSGS 1316
            ..|::|: |::        .|..|.:|:...:|....|:       :...||...    ||
Mouse  1044 IHDKLGK-DSV--------TQHNRSSQVASQLNFGEEAFKFDGPISDRPMSNLEK----VH---- 1091

  Fly  1317 RRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRS-------------SYPPSDP------ 1362
               .:.|||...|.    .....|.....|...||:..|             .:|||:.
Mouse  1092 ---FIVGYAIMRPG----LRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPSERFMKYLL 1149

  Fly  1363 --------------VRELQNMARNEGDNSEDPPF-NFKAMLRKTNYP-----RGSETNTYDFNNR 1407
                          ...||....| |..:|.|.: ..:|:..|.:.|     ....:.|...::.
Mouse  1150 NFISQGPPSYGPFCAERLQRTFAN-GVRAEPPTWLELQAVKSKKHIPIQVILATGRSLTISVDSA 1213

  Fly  1408 RGSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQ----------------QQRAP 1456
            ..|....||..|...||       |:.|::.....|......|.                ::|..
Mouse  1214 STSREICQHVAQKQGLR-------DNLGFSLQVAVYDKFWSLGSGCDHLMDAVAQCEQLARERGE 1271

  Fly  1457 TLRQSP 1462
            :.||:|
Mouse  1272 SQRQAP 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	193/768 (25%)
		MYSc_Myo21	346..1022	CDD:276848	185/737 (25%)
Myo7b	NP_115770.2	MYSc	60..759	CDD:214580	188/755 (25%)
		MYSc_Myo7	79..748	CDD:276832	182/719 (25%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	637..659		8/24 (33%)
		IQ	785..807	CDD:197470	2/21 (10%)
		Mediates interaction with ANKS4B. /evidence=ECO:0000269\|PubMed:26812017	962..1578		61/348 (18%)
		MyTH4	989..1189	CDD:214535	39/224 (17%)
		B41	1196..1409	CDD:214604	15/89 (17%)
		FERM_B-lobe	1299..1400	CDD:271216
		FERM_C1_MyoVII	1403..1499	CDD:270019
		Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250\|UniProtKB:Q6PIF6	1497..2113
		SH3	1500..1560	CDD:302595
		MyTH4	1641..1788	CDD:214535
		B41	1797..2009	CDD:214604
		FERM_M	1907..2009	CDD:278785
		FERM_C2_MyoVII	2005..2100	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810