DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo7a

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_011239990.1	Gene:	Myo7a / 17921	MGIID:	104510	Length:	2250	Species:	Mus musculus

Alignment Length:	890	Identity:	228/890 - (25%)
Similarity:	397/890 - (44%)	Gaps:	165/890 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 DRGYVKRFDEKPEK-------------MYP------EDLAALENPVDENIIESL--RHRILM--- 358
            |.|.::..|::..:             |:|      ||:..|.:..:..|:.:|  |:|..:
Mouse    61 DSGQIQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYT 125

  Fly   359 ---GESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQH 420
               |.:|:  |.||:::|..::...:..|...:|..|...|..||||::||..|.:|..:...|.
Mouse   126 SCGGRTYT--GSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQC 188

  Fly   421 IVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYC 485
            .::||||.:||:.:.:|:::.|..:...:.....:|..:...:....||.|..|::|:|......
Mouse   189 CIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYID 253

  Fly   486 LTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLR 550
            :.|.|.|.:.||....|:|||.||......:.|:|:||...:.:|::.: |:..|....:|.||.
Mouse   254 IHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEGMNEEEK-KKLGLGQAADYNYLA 317

  Fly   551 VPPEVPPSKLKYRRDDPEGNVERYREFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRFR-- 610
            :...:          ..||.|:. :|:.||   ::.:.|...:...:.|:|||||::||:::.
Mouse   318 MGNCI----------TCEGRVDS-QEYANIRSAMKVLMFTDTENWEISKLLAAILHMGNLQYEAR 371

  Fly   611 --QNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVAST 673
              :|....||..:..::..|.||.|:....|..||:..::..|.......:.|:|.|.|||....
Mouse   372 TFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKG 436

  Fly   674 LYSRLVDFIINRIN--MNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYN 736
            :|.||..:|:.:||  :....|..|.....:|.:.|:||||.|..|..|||.||..||.:|..:.
Mouse   437 IYGRLFVWIVEKINAAIYKPPPLEVKNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFV 501

  Fly   737 QRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIM-DRVSEK 800
            :.:|..|..|.:.|.||.:::.|.||:.|||.:..:|..:..:||:.|:..:..|..| .:::.:
Mouse   502 RHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQ 566

  Fly   801 H---SQFV--KKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQ 860
            |   :.:|  |....|:..:.|:.|.:.|:::.|.:.|||.:..::|:...||.::.|..:|...
Mouse   567 HKLNANYVPPKNSHETQFGINHFAGVVYYESQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQAD 631

  Fly   861 LTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANL 925
            :....             |:.::|                 .||::.|:.:...|::      .|
Mouse   632 VAMGA-------------ETRKRS-----------------PTLSSQFKRSLELLMR------TL 660

  Fly   926 GV---HFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL-- 985
            |.   .|||||:.:...||..|...:..:|::..|:::|:..|..|:..|..|.||:.||:.|
Mouse   661 GACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLP 725

  Fly   986 ----AFD----------FDEPVEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQ 1036
                |:.          ..|.|..|.|:            |.:||||:||:.::|    .|.|::
Mouse   726 GVKPAYKQGDLRGTCQRMAEAVLGTHDD------------WQIGKTKIFLKDHHD----MLLEVE 774

  Fly  1037 VKKVIKVQSMMRALLARKRVKGGKVFK-----LGKKGPEHHDVAASKIQKAFRGFRDR-----VR 1091
            ..|.|    ..|.:|.:|.::|   ||     |..|.      ||:.||:.:||...|     :|
Mouse   775 RDKAI----TDRVILLQKVIRG---FKDRSNFLRLKS------AATLIQRHWRGHHCRKNYELIR 826

  Fly  1092 LPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARFQ 1136
            |        |.|........|...|::|       |...|...||
Mouse   827 L--------GFLRLQALHRSRKLHKQYR-------LARQRIIEFQ 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	196/767 (26%)
		MYSc_Myo21	346..1022	CDD:276848	188/717 (26%)
Myo7a	XP_011239990.1	MYSc_Myo7	108..764	CDD:276832	188/717 (26%)
		IQ	801..822	CDD:197470	8/26 (31%)
		PTZ00121	<838..>1010	CDD:173412	7/26 (27%)
		MAP7	<892..970	CDD:368554
		MyTH4	1052..1288	CDD:214535
		FERM1_F1_Myosin-VII	1292..1390	CDD:340612
		B41	1294..1509	CDD:214604
		FERM_C1_MyoVII	1503..1639	CDD:270019
		SH3_MYO7A	1640..1704	CDD:212814
		MyTH4	1782..1931	CDD:214535
		FERM2_F1_Myosin-VII	1936..2033	CDD:340613
		B41	1938..2150	CDD:214604
		FERM_C2_MyoVII	2146..2241	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810