Protein Alignment ninaC and Myo5b

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_006525777.1
• Gene: Myo5b / 17919
• MGIID: 106598
• Length: 1849
• Species: Mus musculus
• Alignment Length: 1248
• Identity: 286/1248 - (22%)
• Similarity: 515/1248 - (41%)
• Gaps: 267/1248 - (21%)

  Fly   286 IENEDEM-RSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPED-----LAALENP- 343
            |.:.||: ||     .||::|    |||.    |:....|.::.....||.|     :..|.||
Mouse    15 IPDPDEVWRS-----AELTKD----YKEG----DKSLQLRLEDDTILEYPVDVQNNQVPFLRNPD 66

  Fly   344 --VDENIIESLRH----------RILMGES---YSFIGDILLSLNSNEIKQEFPQEFHAKYRFKS 393
              |.||.:.:|.|          ::...||   |::.|.:|:::|..|....:.|:....|..::
Mouse    67 ILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQN 131

  Fly   394 RSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATG---R 455
            ..:..||||:||:.||:.|...::.|.|::||||.:||:.:|:..:::...:| |:...|.   :
Mouse   132 MGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVG-GSASDTNIEEK 195

  Fly   456 VESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFH 520
            |.:|...:..:.||.|..|::|:|......:.|.|...:.||....|:|||.||......:.|:|
Mouse   196 VLASSPIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYH 260

  Fly   521 IFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNV-----------ERY 574
            |||......:.. :.||..|....::.|..                ..||.           |:.
Mouse   261 IFYQLCAAASLP-EFKELALTCAEDFFYTA----------------HGGNTTIEGVNDADDFEKT 308

  Fly   575 REFENIL--RDIDFNHKQLETVRKVLAAILNIGNIRFR--QNGKYAEVENTD-IVSRIAELLRVD 634
            |:...:|  ||   :|:  .::.|::|:||::|::..:  ::|....:...| .:|....||.::
Mouse   309 RQALTLLGVRD---SHQ--ISIFKIIASILHLGSVEIQSERDGDSCSISPQDEHLSNFCSLLGIE 368

  Fly   635 EKKF-MWSLTNFIMVKGGIAERRQYTTEEAR----------DARDAVASTLYSRLVDFIINRIN- 687
            ..:. .|           :..|:..||.|..          :||||:|..:|::|..:|:..||
Mouse   369 HSQMEHW-----------LCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFSWIVEHINK 422

  Fly   688 -MNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED 751
             ::.|..:..|     |.:.|::|||.|..|..||..||..||::|..:|..:|..|..|...|.
Mouse   423 ALHTSLKQHSF-----IGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQ 482

  Fly   752 IDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ-----DQDLIMDRVSEKHS---QFVK-K 807
            |....::||||:..:| |:....|:..::|:   .|:     ||:. ..::.|:||   .|.| :
Mouse   483 IPWTLIDFYDNQPCID-LIEAKLGILDLLDE---ECKVPKGTDQNW-AQKLYERHSNSQHFQKPR 542

  Fly   808 HTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFE 872
            .:.|...|.|:..::.|.:..|.:.|||.|..|.|...::|....:..:|
Mouse   543 MSNTAFIVNHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLF--------------- 592

  Fly   873 AVQHKDE---------SERKSYALNTLSAGCISQVNN---LRTLAANFRFTCLTLLKMLSQNANL 925
               |.|:         ..|.|..:|..|:..:.:|.|   .:::...||    |.|.:|.:..|.
Mouse   593 ---HDDKDSAPATNTAKNRSSSKINVRSSRPLIKVPNKEHKKSVGYQFR----TSLNLLMETLNA 650

  Fly   926 GV-HFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDF 989
            .. |:||||:.:.|..|..|......||::|.|||:|:.....|:.||..:.:|..||:.|.
Mouse   651 TTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLM--- 712

  Fly   990 DEPVEMT----KDNCRLLFLRL--KMEGWALGKTKVFLRYYNDEFLARLYELQVKK-VIKVQSMM 1047
             :..|:|    |:.|:.:...|  ..:.:..|:||:|.|.....:|.:|...:.:: .|.:|..:
Mouse   713 -KKRELTNTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKSV 776

  Fly  1048 RALLAR---KRVKGGKVF-------KLGKKGPEH--HDVAASKIQKAF------RGFRDRVRLPP 1094
            |..|.|   :|::...:.       .|.::..||  ...||...||.:      |.:|...|...
Mouse   777 RGWLQRVKYRRLRAATLSLQRFCRGYLARRLAEHLRRTRAAIVFQKQYRMLKARRAYRRVCRATV 841

  Fly  1095 LVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARFQDFV-NLSQQVHIYNQRMVAGLNK 1158
            ::.      :...|.|:|   :.:|     |||:.::|...|.:. ....:.....:|..|.:.:
Mouse   842 IIQ------SFTRAMFVR---RNYR-----QVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQ 892

  Fly  1159 CTRAVPFERINMREVNSSQLGPLPVP------IKKMPFRLDQIPFYDTQYMVDPAN----SISRQ 1213
            |.    |.|:..|:    :|..|.:.      :|::...::. .....|..:|..|    ::|.|
Mouse   893 CA----FRRLKARQ----ELKALKIEARSAEHLKRLNVGMEN-KVVQLQRKIDDQNKEFKTLSEQ 948

  Fly  1214 AFPNQLLTQHMEDDEPWDSPL----QRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGY 1274
            .  :.:.:.|..:.|.....|    |...:.||..|    .::.|:.:|...:......:....:
Mouse   949 L--SAVTSSHAVEVEKLKKELAHYQQNQEADTSLQL----QEEVQSLRTELQKAHSERRVLEDAH 1007

  Fly  1275 FRDPQQLRRNQMQMNMNAYNNAYNSYNSNY-NNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSN 1338
            .::..:||:....:.   :.||.......| |||.....::.|.::|::
Mouse  1008 NKENGELRKRVADLE---HENALLKDEKEYLNNQILCQSKAESSQSSVE---------------- 1053

  Fly  1339 YYRNNPNQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDP-------------PFNFKAMLRK 1390
               .|...::...::||.|  .:.|:|...:.:.. :|..|.             |.|..::...
Mouse  1054 ---ENLLMKKELEEERSRY--QNLVKEYSQLEQRY-ENLRDEVTILKQTPGHRKNPSNQSSLESD 1112

  Fly  1391 TNYPRGSETNTYD 1403
            :|||..|.:...|
Mouse  1113 SNYPSISTSEIGD 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	190/748 (25%)
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	286/1248 (23%)
		MYSc_Myo5	83..750	CDD:276831	186/736 (25%)
		EnvC	1202..>1441	CDD:443969
		Myo5b_CBD	1475..1846	CDD:271261