DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo15

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_034992.2	Gene:	Myo15 / 17910	MGIID:	1261811	Length:	3511	Species:	Mus musculus

Alignment Length:	1422	Identity:	325/1422 - (22%)
Similarity:	555/1422 - (39%)	Gaps:	399/1422 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PTLMRPTN----WSQQINDFISESLEKN----------AENRPMMVEMVEHPFLTELIENEDEMR 293
            |.|..||:    || :|..:.|:|..:.          .:.||...:...|.     |.|...||
Mouse  1140 PRLWPPTDAHCLWS-RIRTYSSQSHLRGHGGDCHKSLWKKTRPQSWQNKMHS-----IRNLPSMR 1198

  Fly   294 SDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILM 358
            |            :..::|..:                   ||:..||:..:..::.:|:.|...
Mouse  1199 S------------REQHREDGV-------------------EDMTQLEDLQETTVLANLKTRFER 1232

  Fly   359 GESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVL 423
            ...|::||.||:|:|...:...:..|...:|..::..||.||:|::|::|:..||..|:.|.:::
Mouse  1233 NLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVII 1297

  Fly   424 SGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLV---NAGTPVNNDSTRCVLQYC 485
            ||||.|||:...:|:::  |......|....:....::|..:|.   ||.|..|::|:|
Mouse  1298 SGESGSGKTEATKLILR--CLAAMNQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSR------ 1354

  Fly   486 LTFGK-------TGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKE-YNLKA 542
              |||       .|.:.||:.:.|:|||.|:......:.|:||||..  ......||:: ::|:.
Mouse  1355 --FGKFVEIFLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYEL--LAGLPAQLRQAFSLQE 1415

  Fly   543 DRNYRYLRVPPEVPPSKLKYRRDDPEGNVE--------RYREFENILRDIDFNHKQLETVRKVLA 599
            ...|.||                :..||.|        .:|.....:..:.|..:..:::.::||
Mouse  1416 AETYYYL----------------NQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFRILA 1464

  Fly   600 AILNIGNIRFRQN----GKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAER--RQY 658
            :||::||:.|.::    .:.|.|.:...:..:||||:|..:....::|  ..|...|.|:  ...
Mouse  1465 SILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAIT--FKVTETIREKIFTPL 1527

  Fly   659 TTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLM 723
            |.|.|.|||||:|..||:.|..::|.|:|..:| |:.   ||.:|.|.|::|||..:.|..|||.
Mouse  1528 TVESAVDARDAIAKVLYALLFGWLITRVNALVS-PKQ---DTLSIAILDIYGFEDLSFNSFEQLC 1588

  Fly   724 INTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ 788
            ||..||.:||.:|:.:|..|..|...|.:|...:.|.||:..::.:..||.|:..|:||  :.|.
Mouse  1589 INYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRILDD--QCCF 1651

  Fly   789 DQDLIMDRVSEKHSQFVKK----HTAT-----------EISVAHYTGRIIYDTRAFTDINRDFVP 838
            .|       :..|: |::|    |.|.           |.::.||.|::.|....|.|.|.|.|.
Mouse  1652 PQ-------ATDHT-FLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVR 1708

  Fly   839 PEMIETFRSSLDESIMLMFTN--------QLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCI 895
            .::::.|..|....:..:|::        :|.|:.::|..::|
Mouse  1709 QDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKA---------------------- 1751

  Fly   896 SQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLD 960
                  .|:||.|:.:.|.|::.:.:...|   ||||::.:.:.:|..|..||:..|::..|||:
Mouse  1752 ------HTVAAKFQQSLLDLVEKMERCNPL---FVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLE 1807

  Fly   961 TVIARQKGFSSRLPFDEFLRRYQFL-AFDFDEPVEMTKDNCRLLFLRL---KMEGWALGKTKVFL 1021
            ||..|::||..||||..|:.||:.| |...:.|.:  .|.|..|..||   ..:.:.:|.:|:||
Mouse  1808 TVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPAD--GDMCVSLLSRLCTVTPDMYRVGISKLFL 1870

  Fly  1022 ------------------------RYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVF 1062
                                    ||....|:.|.:....:|:|.:||..|..|||:|.:..:..
Mouse  1871 KEHLHQLLESMRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQS 1935

  Fly  1063 KLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQV- 1126
            .|..:...|..|...:..|.....|.|.:...|..::  :|::.....:|..........:.|.
Mouse  1936 LLKFRSLVHTYVNRRRYLKLRAEQRRRAQEAWLREQE--ELSKREVVPVRHLEVPAEVAGLLQAA 1998

  Fly  1127 ----------LLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLG-P 1180
                      :...||.|.|....::..:.|.|..|          ..|.|.:.:|.:...|. |
Mouse  1999 AGLKLSSGPRVAVVRAPRLQAEPCVTLPLDINNYPM----------AKFIRCHFKEPSFGMLTVP 2053

  Fly  1181 LPVPIKKMP----------FRLDQIPFYDTQYMVDP-ANSISRQAFPNQLLTQHMEDDEPWDSPL 1234
            |.:|:.::|          |:|      ..::|.|| .:........|.::.|.:.:      |.
Mouse  2054 LKMPLTRLPVEHHAEAISVFKL------ILRFMGDPHLHGTQEMILGNYIVHQGLVE------PA 2106

  Fly  1235 QRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNS 1299
            .|:..:...|                                       ||:..|.||||
Mouse  2107 LRDEILAQLA---------------------------------------NQVWRNPNAYN----- 2127

  Fly  1300 YNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPS------SNYYRNNPNQ--QQRNYQQRSS 1356
                 :.:.|.:..:     .|.|:|    |.|.:..      |:|.:|....  |.|..|...|
Mouse  2128 -----SKRGWLLLAA-----CLSGFA----PSPHLDKFLLKFVSDYGQNGFQAVCQHRLLQAMGS 2178

  Fly  1357 -----YPPSD----PVRELQNMARN----EGDNSEDPPFNFKA---------------------- 1386
                 :||:.    .::|..:||.:    .||....|...:..
Mouse  2179 GAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHTWSTGEAVAGDILKHRGLADGWRGWT 2243

  Fly  1387 --------------------------MLRKTNYPR-------GSETNTYDFNNRRGS-----DSG 1413
                                      :||  ::||       |:|.......:.||.     ||
Mouse  2244 VAMKNGVQWAELAGHDYVLDLVSDLELLR--DFPRQKSYFIVGAEGPLAGRGDTRGVFGNCWDS- 2305

  Fly  1414 DQHTFQPPKLRSTGRRYQDDEGY--NSSSGNYGVSRKFGQQQRAPTLRQSPASVGRS 1468
            |:.|...|:.:....:..|.:||  :...|..|.:    :.||..:.||:..|:|.|
Mouse  2306 DEDTPTRPQPQDHVAKMPDLDGYCSHKEDGTNGET----EAQRWTSNRQAVDSIGES 2358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	12/52 (23%)
		S_TKc	16..282	CDD:214567	12/52 (23%)
		MYSc	327..1034	CDD:214580	210/782 (27%)
		MYSc_Myo21	346..1022	CDD:276848	202/751 (27%)
Myo15	NP_034992.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..1030
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1135
		MYSc	1201..1883	CDD:214580	207/777 (27%)
		MYSc_Myo15	1220..1871	CDD:276838	201/727 (28%)
		Actin-binding. /evidence=ECO:0000255	1776..1783		4/6 (67%)
		FliJ	1870..1960	CDD:280262	18/89 (20%)
		Neck or regulatory domain	1872..2013		23/142 (16%)
		Tail	2014..3511		77/432 (18%)
		MyTH4	2049..2195	CDD:214535	37/215 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2330..2359		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2392..2425
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2460..2509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2565..2584
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2629..2648
		SH3	2852..2931	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2964..2984
		MyTH4	3031..3185	CDD:214535
		B41	3195..3400	CDD:214604
		FERM_B-lobe	3290..3390	CDD:271216
		FERM_C_MyoXV	3396..3497	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810