Protein Alignment ninaC and hum-8

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001294574.1
• Gene: hum-8 / 176872
• WormBaseID: WBGene00002041
• Length: 1279
• Species: Caenorhabditis elegans
• Alignment Length: 1364
• Identity: 312/1364 - (22%)
• Similarity: 540/1364 - (39%)
• Gaps: 296/1364 - (21%)

  Fly   236 QIIRN-----PPPTLMR-----PTNWSQQINDFISESL------EKNAENRPMMVEM-VEHP--- 280
            ||..|     |||.:::     .:..|:.|..|..:::      .|..|.|...|.: |..|
 Worm    10 QITENSEPPKPPPEILKTSAQSSSQKSRGIGTFEPKTIPRDIVDPKKTERRAEKVGINVSQPPPD 74

  Fly   281 -----FLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRG--YVKRFD-----EKPEKMY 333
                 ::|:.   .|..|:  |.:::||....||    .|..:.|  ..:.|:     |...:.:
 Worm    75 YGRTVWITDA---TDGFRA--ARIIDLSATGFTL----RLLDNTGDTVTRVFEDVLACEDDSRRH 130

  Fly   334 PEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNE-IKQEFPQEFHAKYRFKSRSEN 397
            .||...|.:..:..::.::|.|...|:.||::.:||:|:|..: |...:..:...:||.||..:.
 Worm   131 VEDNCQLMHLNEATLLNNIRLRYQNGKIYSYVANILISINPYQTIDGFYSLQKIKEYRGKSLGQK 195

  Fly   398 QPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLC-YLGDGNRGATGRVESSIK 461
            :||||::||.:|::|:.|::.|.|::||||.:||:.:.:.::::|| ..|.|......|:..:..
 Worm   196 EPHIFAIADKSYREMIRHRKSQSIIVSGESGAGKTESQKAVLRYLCENWGSGAGEIQKRLLETNP 260

  Fly   462 AILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYY-- 524
            .:....||.|..||:|:|......:.|..||.::|...:.|:||..|:......:.|:||||.
 Worm   261 ILEAFGNAKTLRNNNSSRFGKFVQIHFADTGNVAGGYVSHYLLETSRICRQAAGERNYHIFYQLI 325

  Fly   525 ------FYDFI-----NQQNQLKEYNLKADRNY-RYLRVPPEVPPSKL-KYRRDDP----EGNVE 572
                  .:.|:     ||.|.||       |.: .:...|.....||: |.|..||    :..|:
 Worm   326 AGSSPELFKFLALGQPNQFNYLK-------RGFIGFFTHPSSGTTSKIPKNRLSDPKFTQDSMVD 383

  Fly   573 RYREFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRFRQ------------NGKYAEVENTD 622
            .:.:|:.:   |:....:.:::..:...:||||::||:.|.:            ||     ...|
 Worm   384 DFSDFQRLEYALKLTGLSEQEIHFIWTTIAAILHLGNVEFEESLDDSRGGCKVFNG-----SEQD 443

  Fly   623 IVSRIAELLRVDEKKFMWSLTNFIM--VKGGIAE---RRQYTTEEARDARDAVASTLYSRLVDFI 682
            :: :.|.||.::..:....|...||  .|||...   |......||...|||::..:||:|.|::
 Worm   444 LI-QAARLLGLETMELKMGLCARIMQTTKGGARGTLIRVPLKPHEACSGRDALSKAIYSKLFDWL 507

  Fly   683 INRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEM 747
            ::|||.::.|.::    ||.:.:.|:.|||.:.:|..||..||..||::|..:||||...|....
 Worm   508 VSRINDSIPFEKS----TNFVGVLDVAGFEFYAKNSFEQFCINFCNEKLQNFFNQRILREEQELY 568

  Fly   748 EAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDA-----------SRSCQDQDLIMDRVSEKH 801
            |.|.::...:.|.||:..::....|.:|||.::|:.           ::...:::....|:....
 Worm   569 EKEGLNVRKIEFIDNQDCIELFELKGNGLFDLLDEEAKFPTSNYKSFTKRAHEENRKHFRLDTPR 633

  Fly   802 SQFVKKHTATE----ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLT 862
            ...||.|....    :.:.||.|.:.|:|:.|.:.|.|.            |..|:.::......
 Worm   634 KSKVKSHRELRDDEGLLIRHYAGSVCYETKHFVEKNDDL------------LHNSLQILIEQSTI 686

  Fly   863 KAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGV 927
            :.  |...|.:..:..:|:     |..||.|            |.|:....|||..|.   :.|.
 Worm   687 RL--LVSLFGSTAYPTKSK-----LKALSVG------------AKFKNQLSTLLIKLE---STGT 729

  Fly   928 HFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP 992
            ||||||:.:.:..|..|....:..|::..|:...:...|.||.||..|.:....||...     |
 Worm   730 HFVRCIKPNNQMIPFEFDGSAILSQLQCAGMTSVLKLMQDGFPSRTGFGDLYACYQKKL-----P 789

  Fly   993 VEMTKDN----CRLLF--LRLKMEGWALGKTKVFLRYYN----DEFLARLYELQVKKVIKVQS-M 1046
            .:::|.:    |:.||  |.|....:..|.||||.|...    |:.:.:..|.....:.||.. :
 Worm   790 PKLSKLDPRMFCKCLFRALGLDQHDFQFGLTKVFFRAGKFAEFDQMMKQDPETMTSLIQKVNEWL 854

  Fly  1047 MRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLV--NEKSGQLNENTAD 1109
            :.|...:.:.....|.|| |..........:::|...||:..|.|....:  ..||..|.:|:.:
 Worm   855 VGARWKQSQYAVWSVIKL-KNKIAWRSAQVTRLQSIARGYLTRQRFSRQIALYRKSVALLKNSKE 918

  Fly  1110 FIRPFAKKWREKSIFQVLLHYRA-------ARFQDFVNLSQQVHI-----------------YNQ 1150
            .         ||.:|::..|.||       :..:|...|...:.:                 |.:
 Worm   919 I---------EKILFRLNEHSRAKYTSSAHSTIRDLEKLVSHIKLTTSANDHFEKAENAYEHYVK 974

  Fly  1151 R---MVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISR 1212
            |   |:|.|.|..::.....|..:...|.:...|.:..||...|..:|     :..::.....::
 Worm   975 RVDSMIADLKKQQKSDELAEIERKRRESEEKERLEIEAKKEAERQREI-----KRKLEEQQQNAQ 1034

  Fly  1213 QAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNI-------- 1269
            :...|.|:::..:..|..:...|..             :||:..:...:|:.|:|.:
 Worm  1035 KEHENYLISEIHKAAEETEKKRQNE-------------EKEKLDKMVSNRLAEADGVALISSKME 1086

  Fly  1270 --------------YNQG-----YFRDPQQLRRNQMQMN-MNAYNNAYNSYNSNYNNQNWGVHRS 1314
                          |:.|     |.||   .....|.:| :.|....:......||  .|
 Worm  1087 IEPSSGSATFRDGKYDVGGCSFAYLRD---TINTSMDINLLKACEEEFRRRLRIYN--EW----- 1141

  Fly  1315 GSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSED 1379
                   |...||....||..::     .....:.....||...||.|  ::|...:.|
 Worm  1142 -------KSRNAPVQDRPPARAA-----LSTVCEELSIMRSIATPSAP--QIQRYFKCE------ 1186

  Fly  1380 PPFNFKAMLRKTNYPRGSETNTYD-------FNNRRGSDSGDQHTF---QPPKLRSTGRRYQDD 1433
                ||...:|.....||.....|       |.:..|.....|.||   :||:....||   ||
 Worm  1187 ----FKENNQKGTCSWGSSIKCEDLDQVSMWFVHFSGQQIQRQLTFTSSRPPQTLIAGR---DD 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	15/70 (21%)
		MYSc_Myo21	346..1022	CDD:276848	193/737 (26%)
hum-8	NP_001294574.1	MYSc_Myo6	143..825	CDD:276833	193/737 (26%)
		CBD_MYO6-like	836..987	CDD:409646	31/160 (19%)
		tolA_full	983..>1076	CDD:274303	17/110 (15%)
		MyUb_Myo6	1099..1139	CDD:439319	8/42 (19%)
		Myosin-VI_CBD	1180..1276	CDD:465157	19/77 (25%)