Protein Alignment ninaC and hum-1

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_492393.1
• Gene: hum-1 / 172698
• WormBaseID: WBGene00002035
• Length: 1100
• Species: Caenorhabditis elegans
• Alignment Length: 1157
• Identity: 283/1157 - (24%)
• Similarity: 468/1157 - (40%)
• Gaps: 280/1157 - (24%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            :|:..|....:::|:|:|:.|:.....:::||.:|:|:|..:....|.::....|:..::.||.|
 Worm    17 DDMVLLPKLTEQSIVENLKKRLQANSIFTYIGPVLISVNPFKQMPYFTEKEMLLYQGAAQYENAP 81

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            ||:::||..|::||...|.|.:::||||.:||:.||:.::.::..:..|     |:....||.::
 Worm    82 HIYALADNMYRNMLIDNESQCVIISGESGAGKTVNAKFIMNYISRISGG-----GQKVQHIKDVI 141

  Fly   465 M--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHI 521
            :        ..|:.|..|.:|:|......:.|.:.|:..|...:.::|||.||...:....|||:
 Worm   142 LQSNPLLEAFGNSATVRNWNSSRFGKYVEIVFSRGGEPIGGKLSNFLLEKSRVVHQNEGDRNFHV 206

  Fly   522 FYYFYDFINQQNQLKEYNLKADRN------------YRYLRVPPEVPPSKLKYRRDDPEGNVERY 574
            ||             :....||:|            |.||.:..       .::.||.:..
 Worm   207 FY-------------QLCAGADKNLRSTFGIGELQYYNYLNMSG-------VFKADDTDDG---- 247

  Fly   575 REFENILRDIDF----NHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDE 635
            :|||:.|..:..    :..|||.:| ::|.:|:||||.|.:...:|.|...|.:...|.||.:..
 Worm   248 KEFESTLHAMKVVGVNDQDQLEVLR-IVATVLHIGNITFTEENNFAAVSGKDYLEYPAFLLGLTS 311

  Fly   636 KKFMWSLTNFIM-VKGGIAERR---QYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAV 696
            ......||...| .|.|..:..   :...|:|...|||....:|:||.|:::.::|..|:.....
 Worm   312 ADIEAKLTGRKMESKWGTQKEEIDMKLNVEQASYTRDAWVKAIYARLFDYLVKKVNDAMNITSQS 376

  Fly   697 FGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED-----IDTIN 756
            ..|..::.|.|::|||.||.||.||..||.:||::     |:|||...|:.|.|:     |....
 Worm   377 TSDNFSVGILDIYGFEIFNNNGFEQFCINFVNEKL-----QQIFIELTLKAEQEEYVREGIKWTE 436

  Fly   757 LNFYDNKTALDNLLTK-PDGLFYIIDDASRSCQDQDLIMDRVSEKHSQ--FVKKHTATEIS---- 814
            ::::|||...|.:.|| |.|:..::||   :|          ::.|.|  .|.:...|.:|
 Worm   437 IDYFDNKIVCDLIETKRPPGIMSLLDD---TC----------AQNHGQREGVDRQLLTTLSKSFA 488

  Fly   815 -------------VAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMF-TNQLTKAG 865
                         :.||.|.:.|:...|.|.|||.:.|::|...:.|....|..:| .|....||
 Worm   489 GHPHFGPGSDSFVIKHYAGDVTYNVDGFCDRNRDVLYPDLILLMQKSSRPFIQALFPENVAASAG 553

  Fly   866 NLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFV 930
            .....|.                          ..:||.|.       ||::.|.:   ...|:|
 Worm   554 KRPTTFS--------------------------TKIRTQAN-------TLVESLMK---CSPHYV 582

  Fly   931 RCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLA------FDF 989
            |||:.:...:|..:....|:.|::.||:.:.:..|:.||:.|..||:|.:||..::      |..
 Worm   583 RCIKPNETKRPNDWEESRVKHQVEYLGLRENIRVRRAGFAYRRAFDKFAQRYAIVSPQTWPCFQG 647

  Fly   990 DEPVEMTKDNCRLLFLRLKME--GWALGKTKVFLRYYNDEFLARLYELQVKK----VIKVQSMMR 1048
            |:     :..|.::...:.||  .:.:||||:|::  |.|.|..|.|.:.:|    ...:|...|
 Worm   648 DQ-----QRACEIICDSVHMEKNQYQMGKTKIFVK--NPESLFLLEETRERKFDGYARVIQKAWR 705

  Fly  1049 ALLARKR-VKGGKV---FKLGKK----------------GPEHHDVAASKIQKAFRGFRDRVRLP 1093
            ...|||: :|..:.   ...|||                |.|||....|.:     |.|.||...
 Worm   706 QFSARKQHIKQKEQAADLMYGKKERRRYSLNRNFVGDYIGLEHHPTLQSLV-----GKRQRVLFA 765

  Fly  1094 PLVNEKSGQLNENTADFI----------RPFAKKWREK-SIFQV--------------LLHYRAA 1133
            ...|:...:......|.:          :...|...|| .|.:|              |..|:
 Worm   766 CTANKYDRKFRVTKLDLLLTVNHLTLIGKEKVKNGPEKGKIVEVIKRQFDLPQIKSIGLSPYQ-- 828

  Fly  1134 RFQDFVNL--------SQQVHIYNQRMVAGLNKCTRAVPFERIN---MREVNSSQLGPLPVPIKK 1187
              .|||.|        |.....:.......|:|..:    ||.|   ..:..||.:    |..||
 Worm   829 --DDFVILYLGNDDYSSLLETPFKTEFCTALSKAYK----ERTNGTLHLDFRSSHV----VSYKK 883

  Fly  1188 MPFRLDQIPFYD----TQYMVDPANSISRQAFPN-QLLTQHMEDDEPWDSPLQRNPSMTSCALTY 1247
            |.|     .|.|    .|:..|..:|..:...|| ::|...:....|       |.:..|.....
 Worm   884 MKF-----DFSDGKRTVQFGNDGTSSAEKTLKPNGKVLNVSIGTGLP-------NTTRPSTERPQ 936

  Fly  1248 NAY--KKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYN------SYNSNY 1304
            ..|  :::| .:|:..|..:::..|.|.     .|.:..:..:..:..||.||      |.|..|
 Worm   937 GGYTPRRDQ-LRTSTRRTKQNNQSYGQN-----GQSQAMRAPVPAHGMNNNYNQTPAPVSTNHQY 995

  Fly  1305 N-------------NQNWGVHRSGSRRNSLKGYAAPP-----PPPPPMPSSN 1338
            :             ||...::.||: .||..|...||     ||||..|..|
 Worm   996 SQEPARIPVMGNVINQLNNMNLSGN-GNSPAGRGPPPARGPKPPPPAKPKLN 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	191/737 (26%)
hum-1	NP_492393.1	MYSc	9..690	CDD:214580	198/763 (26%)
		Myosin_TH1	717..920	CDD:461801	46/224 (21%)
		SH3	1051..1100	CDD:473055