Protein Alignment ninaC and MYO3B

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_011508956.1
• Gene: MYO3B / 140469
• HGNCID: 15576
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 1164
• Identity: 392/1164 - (33%)
• Similarity: 625/1164 - (53%)
• Gaps: 110/1164 - (9%)

  Fly     2 MYLPYAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKI----QHYDEEHQVSIEEEYR 62
            |.|....||||||.:||.|.|.:|...||::.....:..:.|:||    ...|||    ||.||.
Human    22 MMLGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEE----IEAEYN 82

  Fly    63 TLRDYCDHPNLPEFYGV-YKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYII 126
            .|:...:|||:.:|||: ||.....| .::|.|:|.|.||:..::|..||:..:|:.|..|:||:
Human    83 ILQFLPNHPNVVKFYGMFYKADHCVG-GQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYIL 146

  Fly   127 RETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEV 191
            .........|:.|.::|||::|:|||||..|.|||.|||:|.|:.||..:|.|.:|:|.||||||
Human   147 YGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 211

  Fly   192 VSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQIN 256
            ::..:..:.....|.|||:||||.|||.||.||..||||.:.:|:|.|||||||:.|..|.::.|
Human   212 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFN 276

  Fly   257 DFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGY 321
            .|||:.|.|:.|.||.:..:::|||:..:......::..:|::|:..:....:.|...   :|.:
Human   277 HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRH---ERMH 338

  Fly   322 VKR---FDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQ 383
            .:|   .::..:....:||..||...::.||..|:.|......|:::||||::||..:....:..
Human   339 TRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSP 403

  Fly   384 EFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDG 448
            :|...|....|:.|.||||:.||.|||.|:...:.|.||:||||.|||:.:|.|:::||.:||..
Human   404 QFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKA 468

  Fly   449 N----RGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRV 509
            |    |....:|.|.::|   ..|:.|.:|::|:|......:.|..||.:.||..:.|:|||.||
Human   469 NNQTLREKILQVNSLVEA---FGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRV 530

  Fly   510 ATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYL-----RVPPEVPPSKLKYRRDDPEG 569
            ......:.|||||||.|..::.|.:|.::.|..::..||:     ||..:: .||..|||
Human   531 IKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDI-TSKESYRR----- 589

  Fly   570 NVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF------RQNGKYAEVENTDIVSRIA 628
               ::...::..|.|.|..|::.:|.::||.|||||||.|      .|..| :||.|.:.:...|
Human   590 ---QFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDK-SEVPNAEALQNAA 650

  Fly   629 ELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFP 693
            .:|.:..::...:||:..:|..|....|..|.:.|.|.|||::..||.||..:|:||||..:...
Human   651 SVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPD 715

  Fly   694 RAVF---GDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTI 755
            ..:.   |..|..|: |:||||.|.||..|||.||..|||:||::||.:|..|.:|.:.|.||.:
Human   716 ENICSAGGGMNVGIL-DIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAV 779

  Fly   756 NLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ--DQDLIMDRVSEKHSQFVKKHTATEI--SVA 816
            .:.:.||:..||..|.||.||..::|:.||..|  ||.|:.........::..:....|:  .:.
Human   780 PVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQ 844

  Fly   817 HYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNL------------TM 869
            ||.|:::||.....:.|||.:|.:::...|:|.::.:..:|:..|||.|||            ::
Human   845 HYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSL 909

  Fly   870 P------------FEAVQHKDESERKSYALNTLSAGCISQVNNLR--TLAANFRFTCLTLL-KML 919
            |            .|.::|.:|:                  .|::  |:|:.||::.:.|| ||:
Human   910 PPHFSAGKAKVDTLEVIRHPEET------------------TNMKRQTVASYFRYSLMDLLSKMV 956

  Fly   920 SQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQF 984
            ....    ||||||:.:.:.:...|..:.|..|:::.|:|:||..|::|:|.|:.|:||::||.:
Human   957 VGQP----HFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYY 1017

  Fly   985 LAFDFDEPVEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRA 1049
            |||...:....:|::|..:..:.:::.|.||||||||:||:.|.|..|....:.:|:.:|:..:.
Human  1018 LAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKG 1082

  Fly  1050 LLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTA 1108
            .|..:|.|  :|.:..:||       |..||.|:||:..|.:...:.|.::.....|.|
Human  1083 WLGARRYK--RVREKREKG-------AIAIQSAWRGYDARRKFKKISNRRNESAAHNQA 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	120/277 (43%)
		MYSc_Myo21	346..1022	CDD:276848	236/724 (33%)
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	123/285 (43%)
		MYSc_Myo3	366..1055	CDD:276830	236/724 (33%)