Protein Alignment ninaC and myo9a

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_002934596.2
• Gene: myo9a / 100216086
• XenbaseID: XB-GENE-492474
• Length: 2613
• Species: Xenopus tropicalis
• Alignment Length: 1383
• Identity: 304/1383 - (21%)
• Similarity: 547/1383 - (39%)
• Gaps: 369/1383 - (26%)

  Fly   311 KEPELFVDRGYVKRFDEKPEKMYP--EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLN 373
            :|....|:||::      |::..|  |||..|.:..:..::|:||.|....:.|:::|.||:::|
 Frog   131 EERRHMVERGFL------PQQQGPECEDLCGLPDLSERALLETLRTRFRQEKIYTYVGTILVAVN 189

  Fly   374 SNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLL 438
            .......:..::...|..:...:.:|||::|||.||..||..:..|.||:|||:.|||:.:...|
 Frog   190 PFRFLPIYNPKYVKMYDNRRLGDREPHIYAVADAAYHAMLRRQRNQCIVISGETGSGKTQSTNFL 254

  Fly   439 IKHLCYLGDGNRGATGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGK--------T 491
            |.||..|  ..:|....||..|    ..:....||.|..||:|:|        |||        |
 Frog   255 IHHLTAL--SQKGYASGVEQIILGAGPVLEAFGNAKTYQNNNSSR--------FGKFIQVNYHET 309

  Fly   492 GKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVP 556
            |.:.||....|:|||.|:...:..:.|:|:|||.....:::.: .|::|:...:|.||......|
 Frog   310 GTVRGAYVEKYLLEKSRLVYQEQQERNYHVFYYLLAGASEEEK-AEFHLEHPESYHYLNQRTRKP 373

  Fly   557 PSKL---KYRRDDPE---GNVERYR-EFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRFRQ 611
            ..::   .|..|:.:   |..|..| :||.:   :..:.|.......:..:|:|||::|||::::
 Frog   374 QRQVWGESYGEDETDSLGGEGEDLRHDFERLQLAMEMVGFMPATRRQIVSLLSAILHLGNIQYKR 438

  Fly   612 ---NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVAST 673
               ..:..::.|.:.::.::|||:|.|:..:.:|.....|..|......|...||...||::|.:
 Frog   439 KTYRDESIDISNPETLNIVSELLKVREEMLLDALITRKTVTVGEKLILPYRLPEAITVRDSLAKS 503

  Fly   674 LYSRLVDFIINRIN---MNMSFPRAVFG-DTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYH 734
            |||.|.|:|:.|||   :|::......| .|.:|.:.|:||||.:..|..||..||..||::|::
 Frog   504 LYSALFDWIVFRINHALLNINSKAIDEGSQTLSIGVLDIFGFEDYGTNSFEQFCINYANERLQHY 568

  Fly   735 YNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSE 799
            :||.:|..|.....:|.|...|:.:.||...::.:..||.||..::|:.|...|.....:....:
 Frog   569 FNQHLFQLEQELYRSEGISWSNITYSDNGGCINLISKKPTGLLQLLDEESNFPQATHQTLLEKFK 633

  Fly   800 KHSQ---FVKKHTATE--ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMF-- 857
            :|::   :::.....|  ..:.||.|::.|..:.|.:.|.|.:.|:::...|||.:..|..|.
 Frog   634 RHNERNPYIEFPAVMEPAFIIHHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFIRGMISI 698

  Fly   858 ---------------------------TNQLTKAGNLTMP------------FEAVQH------- 876
                                       :::.|.:|.|..|            |..:||
 Frog   699 SPVGAFRWALLRAFFRAVEAFKQSGKSSSKKTGSGPLCTPGPPGSAHKGISSFSFLQHPVHQRSL 763

  Fly   877 -------------------------------KDESERK----SYALNTLSAG------------- 893
                                           :|.|.::    |...|.||:.
 Frog   764 QILQRCQTDQYNIPRRTPRTPLSDLQGANTIQDRSPKEMSWTSRRQNRLSSSNSYLEGGGIFISS 828

  Fly   894 -----------------------------------------CISQVNNLR--------------- 902
                                                     .:..::||.
 Frog   829 SSSNQNNSTDSKLLERAHGILMRNKSTKNKPALPKHLLDVKSLKHLSNLTLHDRITKSLLHHHKK 893

  Fly   903 ----TLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVI 963
                :::|.|:.:...|::.|.|   ...:||:|||::.|..|..|...:|.:|::..|:|:||.
 Frog   894 KKPPSISAQFQTSLNKLMETLGQ---AEPYFVKCIRSNAEKVPMRFDDALVLRQLRYTGMLETVR 955

  Fly   964 ARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRL--KMEGWALGKTKVFLRYYND 1026
            .||.|:|.:.||.:|:.::..|   ..:.:.....:.:..|.|:  ..:.:.:|:|.|||:....
 Frog   956 IRQSGYSCKYPFQDFVTQFSVL---LPKDISPVHQSIKEFFWRIGHSPDQYQVGRTMVFLKEQER 1017

  Fly  1027 EFLAR-LYELQVKKVIKVQSMMRALLARKRV-----------KGGKVFK---LGKKGPEHHDV-- 1074
            :.|.. |::..::::|.:|..:||.|.|||.           :..:.:|   :|::.|..|.:
 Frog  1018 QCLMEMLHQTVLQRIILLQRWIRARLQRKRFLLFRDAVITIQRCWRHYKRRWIGEEPPVPHTLIP 1082

  Fly  1075 --AASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAA-RFQ 1136
              ||..||..:|..|.|:|.  |..:.|..:.:|.          |||.:    |...||| ..|
 Frog  1083 CEAACIIQSWWRCRRTRLRF--LKTKNSVLVIQNC----------WREHN----LKKQRAAVSIQ 1131

  Fly  1137 DFVNLSQQVHIYNQRMVAGLNKCT----------------RAVPFERIN--MREVNSSQLGPLPV 1183
            .:...|.|..:|.:::     ||.                .::..::.|  :.|::....|..|:
 Frog  1132 SWWRASYQKSLYQRKL-----KCIIVLQAASRGYLARCRFHSLMDQKSNSFVHELSQGDKGSEPI 1191

  Fly  1184 PIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYN 1248
            .:              |.:..|             :...|::|...::.|.|:... :||:...|
 Frog  1192 RL--------------TAHTPD-------------MNCTHLQDSASFELPGQQLLD-SSCSADLN 1228

  Fly  1249 AYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRR----NQMQMNMNAYNNAYNSYNSNYNNQNW 1309
            ....|...:   :|....:|...:..||..::.||    .|.|.::..           ...::.
 Frog  1229 TIPVEVHIR---ERPKSLENPNQRTVFRAKRESRRLRELEQAQFSLEL-----------LKVRSG 1279

  Fly  1310 GVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYR---NNPNQQQRNYQQRSSYP------PSDPVRE 1365
            |:..|..||.|  |.........|...|:.:.   .||.:..::.:...::|      ||.|.
 Frog  1280 GISPSEERRWS--GEVLDKLVDTPESDSSVFSLELINPEENLQSPKDPPTHPSASEIIPSSPT-- 1340

  Fly  1366 LQNMARNEGDNSED---------------------PPFNFKAMLRKTNYPRGSETNTYDFNNRRG 1409
             ..:|.|..:..:|                     ||::  |.|.....|          :|..|
 Frog  1341 -DTLASNATEACQDFPICDMAASKTYDPSILSRIEPPYS--ATLEPQCTP----------SNDHG 1392

  Fly  1410 SDSGDQHTFQPPKLRSTG 1427
            |...::|.:.|.||.:.|
 Frog  1393 SHLSNEHHYTPEKLPTCG 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	203/867 (23%)
myo9a	XP_002934596.2	Ubl1_cv_Nsp3_N-like	17..112	CDD:475130
		MYSc_Myo9	162..1013	CDD:276836	203/867 (23%)
		IQ	1145..1167	CDD:197470	2/26 (8%)
		C1_Myosin-IXa	2061..2118	CDD:410433
		RhoGAP	2127..2312	CDD:470621
		APG6_N	<2393..>2438	CDD:465452