DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt10 and WNT10B

DIOPT Version :9

Sequence 1:	NP_609109.3	Gene:	Wnt10 / 34011	FlyBaseID:	FBgn0031903	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_003385.2	Gene:	WNT10B / 7480	HGNCID:	12775	Length:	389	Species:	Homo sapiens

Alignment Length:	448	Identity:	174/448 - (38%)
Similarity:	241/448 - (53%)	Gaps:	97/448 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 MIILACCTRWLYG------LP-----DGRATCRSVPGLTKDQVELCYKASDVTAAALEGLDMAIR 109
            ::.||.|:|.|..      ||     .....|.::.||:|.|:.||.:..||||:||:||.:|:.
Human    17 LLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVH 81

  Fly   110 ECQIQFQWHRWNCSSLSTKSRNPHASSLLKKGYRESAFAFAISAAGVAHSVARACSQGRLMSCGC 174
            |||.|.:..|||||:|....|.||.|::||:|:|||||:|::.||||.|:||.|||.|:|:||||
Human    82 ECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGC 146

  Fly   175 -------DPTINRKTLNKNLRQSLDKEKKQFLQYLET---NQILTPEEEKKYERSKIASRWKWGG 229
                   ...:..|.|.   .|:|.: .|.|...|.:   ....:|..:         ..|:|||
Human   147 GWKGSGEQDRLRAKLLQ---LQALSR-GKSFPHSLPSPGPGSSPSPGPQ---------DTWEWGG 198

  Fly   230 CSHNMDFGVEYSKLFLDCREKAGDIQSKINLHNNHAGRIAVSNNMEFRCKCHGMSGSCQLKTCWK 294
            |:|:||||.::|:.|||.||...|||:::.:|||..||..|:.|::.:|||||.|||||.||||:
Human   199 CNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWR 263

  Fly   295 SAPDFHIVGKVLKHQFRKAILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGSTSPDLDSTDASGG 359
            :||:|..||..|:.:..:||.:|..|             ||        ||:..|.|
Human   264 AAPEFRAVGAALRERLGRAIFIDTHN-------------RN--------SGAFQPRL-------- 299

  Fly   360 HDDGGTGDSETRRHDELGVERGTRQPSADKNAARMARKLETSLFYYQRSPNFCERDLGADIQGTV 424
                                    :|          |:|...|.|:::||:|||||......||.
Human   300 ------------------------RP----------RRLSGELVYFEKSPDFCERDPTMGSPGTR 330

  Fly   425 GRKCNRNTTTSDGCTSLCCGRGHSQVIQRRAERCHCKFQWCCNVECEECHVEEWISIC 482
            ||.||:.:...|||.||||||||:.:.|.|.|||||:|.|||.|.|:||.|.||:::|
Human   331 GRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVC 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt10	NP_609109.3	wnt	82..466	CDD:278536	155/393 (39%)
WNT10B	NP_003385.2	Wnt_Wnt10b	45..389	CDD:381730	167/420 (40%)
WNT10B	NP_003385.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..197		5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152274
Domainoid	1	1.000	328	1.000	Domainoid score	I1167
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20721
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2444
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1241694at2759
OrthoFinder	1	1.000	-	-		FOG0004126
OrthoInspector	1	1.000	-	-		otm40557
orthoMCL	1	0.900	-	-		OOG6_107889
Panther	1	1.100	-	-	LDO	PTHR12027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5519
SonicParanoid	1	1.000	-	-		X2869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790