DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt10 and Wnt6

DIOPT Version :9

Sequence 1:	NP_609109.3	Gene:	Wnt10 / 34011	FlyBaseID:	FBgn0031903	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001260188.1	Gene:	Wnt6 / 34010	FlyBaseID:	FBgn0031902	Length:	420	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	137/483 - (28%)
Similarity:	206/483 - (42%)	Gaps:	118/483 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LHLIVMIILACCTR---WLYG---LPDGRATCRSVPGLTKDQVELC-YKASDVTAAALEGLDMAI 108
            |.:|.::|.|....   |..|   |.|....|:....|.....|:| :.::.:....:.|:::..
  Fly     4 LMVIAILIFAMPMTGFGWAEGTNILLDPNLMCKKTRRLRGKLAEICRHDSALLKEIIINGINLGF 68

  Fly   109 RECQIQFQWHRWNCSSLSTKSRNPHASSLLKKGYRESAFAFAISAAGVAHSVARACSQGRLMSCG 173
            |||:.||:..||||:.|....|     .:|.:..||:.|..||:||||.::|.:||:.|:|:.|.
  Fly    69 RECEFQFRNRRWNCTVLRKSMR-----KILMRDSRETGFVNAITAAGVTYAVTKACTMGQLVECS 128

  Fly   174 CD--------------------PTINRKTLNKNLRQSL---DKEKKQFLQYLETNQILT---PEE 212
            ||                    ..:.|:.....|||.:   |:...|.|..:.....:|   |.|
  Fly   129 CDKAHMRRNGGQPQMVTAATAEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNNASTMTDIAPVE 193

  Fly   213 EKKYERSKIASR----------------WKWGGCSHNMDFGVEYSKLFLDC--REKAGDIQSKIN 259
            .:.....:...|                |:|||||.|::||:.:|::|||.  |::..|:.:.:.
  Fly   194 HRGGRNRRPGGRRGRRKFWDNIKFPEGQWEWGGCSDNVNFGLRHSRVFLDAKQRQRRSDLGTLVK 258

  Fly   260 LHNNHAGRIAVSNNMEFRCKCHGMSGSCQLKTCWKSAPDFHIVGKVLKHQFRKAILVDQSNLGNG 324
            .|||:|||:|:.:.|...|||||:||||.:||||...|.|..|...|:.::..|..|...|.||
  Fly   259 FHNNNAGRLAIRDAMRLECKCHGLSGSCTVKTCWLKMPPFREVAGRLRDRYDSARKVTLRNDGN- 322

  Fly   325 EPVVVLKRARNKKSNGGSGSGSTSPDLDSTDASGGHDDGGTGDSETRRHDELGVERGTRQPSADK 389
                                 |..|:                                 .|.
  Fly   323 ---------------------SFMPE---------------------------------SPH--- 330

  Fly   390 NAARMARKLETSLFYYQRSPNFCERDLGADIQGTVGRKCNRNTTTSDGCTSLCCGRGHSQVIQRR 454
              ||.|.|.:  |.:...||:||..:......||.||:||..::.||.|..|||.|||::.|...
  Fly   331 --ARPANKYQ--LVFADDSPDFCTPNSKTGALGTQGRECNVTSSGSDRCDRLCCNRGHTRRIVEE 391

  Fly   455 AERCHCKFQWCCNVECEECHVEEWISIC 482
            ...|.|.|:|||.|.||:|.....::.|
  Fly   392 QTNCKCVFKWCCEVTCEKCLEHRAVNTC 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt10	NP_609109.3	wnt	82..466	CDD:278536	121/428 (28%)
Wnt6	NP_001260188.1	wnt	41..419	CDD:278536	127/444 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D68684at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850