DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt10 and Wnt10b

DIOPT Version :9

Sequence 1:	NP_609109.3	Gene:	Wnt10 / 34011	FlyBaseID:	FBgn0031903	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001101581.1	Gene:	Wnt10b / 315294	RGDID:	1304988	Length:	389	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	176/460 - (38%)
Similarity:	246/460 - (53%)	Gaps:	101/460 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SRHCNLHLIVMIILACCTRWLYG------LP-----DGRATCRSVPGLTKDQVELCYKASDVTAA 99
            ||...|.|..::.||..:|.|..      ||     .....|.::.||:|.|:.||.::.||||:
  Rat     7 SRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRSPDVTAS 71

  Fly   100 ALEGLDMAIRECQIQFQWHRWNCSSLSTKSRNPHASSLLKKGYRESAFAFAISAAGVAHSVARAC 164
            ||:||.:|:.|||.|.:..|||||:|....|.||.|::||:|:|||||:|::.||||.|:||.||
  Rat    72 ALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATAC 136

  Fly   165 SQGRLMSCGCDPTINRKTLNKNLRQSLDKEKKQFLQYLETNQILTPEEEKKYERSKIA------- 222
            |.|:|:||||    ..|...:.     |:.:.:.||.    |.|:  ..|.:..|:.:
  Rat   137 SLGKLVSCGC----GWKGSGEQ-----DRLRAKLLQL----QALS--RGKSFPHSQPSPIPGSVP 186

  Fly   223 -----SRWKWGGCSHNMDFGVEYSKLFLDCREKAGDIQSKINLHNNHAGRIAVSNNMEFRCKCHG 282
                 ..|:||||:|:||||.::|:.|||.||...|||:::.:|||..||..|:.|::.:|||||
  Rat   187 GPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHG 251

  Fly   283 MSGSCQLKTCWKSAPDFHIVGKVLKHQFRKAILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGST 347
            .|||||.||||::||:|..:|..|:.:..:||.:|..|             ||        ||..
  Rat   252 TSGSCQFKTCWRAAPEFRAIGAALRERLGRAIFIDTHN-------------RN--------SGVF 295

  Fly   348 SPDLDSTDASGGHDDGGTGDSETRRHDELGVERGTRQPSADKNAARMARKLETSLFYYQRSPNFC 412
            .|.|                                :|          |:|...|.|:::||:||
  Rat   296 QPRL--------------------------------RP----------RRLSGELVYFEKSPDFC 318

  Fly   413 ERDLGADIQGTVGRKCNRNTTTSDGCTSLCCGRGHSQVIQRRAERCHCKFQWCCNVECEECHVEE 477
            |||......||.||.||:.:...|||.||||||||:.:.|.|.|||||:|.|||.|.|:||.|.|
  Rat   319 ERDPALGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTE 383

  Fly   478 WISIC 482
            |:::|
  Rat   384 WVNVC 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt10	NP_609109.3	wnt	82..466	CDD:278536	154/395 (39%)
Wnt10b	NP_001101581.1	Wnt_Wnt10b	45..389	CDD:381730	166/422 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345772
Domainoid	1	1.000	326	1.000	Domainoid score	I1151
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20721
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1241694at2759
OrthoFinder	1	1.000	-	-		FOG0004126
OrthoInspector	1	1.000	-	-		otm44693
orthoMCL	1	0.900	-	-		OOG6_107889
Panther	1	1.100	-	-	LDO	PTHR12027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2869
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900