DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt6 and wnt10b

DIOPT Version :9

Sequence 1:	NP_001260188.1	Gene:	Wnt6 / 34010	FlyBaseID:	FBgn0031902	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_835737.1	Gene:	wnt10b / 30308	ZFINID:	ZDB-GENE-980526-524	Length:	427	Species:	Danio rerio

Alignment Length:	457	Identity:	147/457 - (32%)
Similarity:	202/457 - (44%)	Gaps:	80/457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLMVIAILIF-AMPMTG---FGWAEGTNILLDPNLMCKKTRRLRGKLAEICRHD-----SALLK 57
            |:|:|.|.|:. |..:.|   .|.......:|.||.:|.:...|..|...:|...     |||
Zfish    11 RVLIVTAALLSPAFTVLGNDILGLKVAGEPVLTPNAVCLRLAGLTKKQMRLCVRSPDVTASAL-- 73

  Fly    58 EIIINGINLGFRECEFQFRNRRWNCTVLRK-----SMRKILMRDSRETGFVNAITAAGVTYAVTK 117
                .||.:...||:.|.|::||||:.|..     ....||.|..||:.|..::.||||.::|..
Zfish    74 ----QGIQVAIHECQHQLRDQRWNCSSLENHGKLPHQSAILNRGFRESAFSLSLLAAGVVHSVAS 134

  Fly   118 ACTMGQLVECSC--------DKAHMRRNGGQPQMVTAATAEAAL----ERQQQAAMLRQQMP--L 168
            ||::|:|..|.|        ||..::..  |.|:.|...:..:|    |...:.:.|...:|  |
Zfish   135 ACSLGKLRGCGCEAKRRLDDDKIRLKLT--QLQLQTFQRSGVSLAGAGENTPELSSLHGSLPANL 197

  Fly   169 QDQHPSQRLSRMNNASTMTDIAPVEHRGGRNRRPGGRRGRRKFWDNIKFPEGQWEWGGCSDNVNF 233
            ...||...|..:.:..||.                               :..|||||||.::.|
Zfish   198 HSSHPMSLLKPLPDEVTML-------------------------------QDTWEWGGCSHDIRF 231

  Fly   234 GLRHSRVFLDAKQRQRRSDLGTLVKFHNNNAGRLAIRDAMRLECKCHGLSGSCTVKTCWLKMPPF 298
            |:|.||.:||::...|  |:....:.|||..||..:.|.||.:|||||.||||..||||...|.|
Zfish   232 GVRFSRDWLDSRGSPR--DIHARTRIHNNRVGRQVVTDNMRRKCKCHGTSGSCQFKTCWYVSPEF 294

  Fly   299 REVAGRLRDRYDSARKVTLRNDGNSFM-----------PESPHARPANKYQLVFADDSPDFCTPN 352
            |.|...||:::.:|..:..:|..|...           |.....|.:...:||:.:.|||||...
Zfish   295 RLVGSLLREKFLTAIFINSQNKNNGVFNSRTGGSTGSDPLRGQRRRSISRELVYFEKSPDFCDRE 359

  Fly   353 SKTGALGTQGRECNVTSSGSDRCDRLCCNRGHTRRIVEEQTNCKCVFKWCCEVTCEKCLEHRAVN 417
            ....:||||||.||.:|.|.|.|..|||.|||..........|.|.|.|||.|.||:|.....||
Zfish   360 PAVDSLGTQGRICNKSSPGMDGCGSLCCGRGHNILKQARSERCHCRFHWCCYVLCEECKVTEWVN 424

  Fly   418 TC 419
            .|
Zfish   425 VC 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt6	NP_001260188.1	wnt	41..419	CDD:278536	134/412 (33%)
wnt10b	NP_835737.1	wnt	50..427	CDD:306592	135/418 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810