Protein Alignment wg and WNT1

DIOPT Version :9

• Sequence 1: NP_523502.1
• Gene: wg / 34009
• FlyBaseID: FBgn0284084
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_005421.1
• Gene: WNT1 / 7471
• HGNCID: 12774
• Length: 370
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 207/469 - (44%)
• Similarity: 257/469 - (54%)
• Gaps: 113/469 - (24%)

  Fly     5 YIFVICLMALCSGGSSLSQVEGKQKSGRGRGSMWWGIAKVGEPNNI-----TPIMYMDPAIHSTL 64
            ::....|:||.:..::|:    ...|||     ||||..|....|:     :..:.::|:: ..|
Human    10 WVSATLLLALAALPAALA----ANSSGR-----WWGIVNVASSTNLLTDSKSLQLVLEPSL-QLL 64

  Fly    65 RRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRETSF 129
            .||||||:|.|||:|.::..|...|:.||:.|||||||||.|   :.|.:||||||:||||||:|
Human    65 SRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPT---APGPHLFGKIVNRGCRETAF 126

  Fly   130 IYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSPQANHQAGSVAGVRDWEWGGCSDNIGFGFK 194
            |:|||||.||||:||:||||:||||||||  :.|.|          |..||.||||||||.||..
Human   127 IFAITSAGVTHSVARSCSEGSIESCTCDY--RRRGP----------GGPDWHWGGCSDNIDFGRL 179

  Fly   195 FSREFVDTGERGRNLREKMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGD 259
            |.|||||:||:||:||..||||||||||..|.:|||||||||||||||||:||||||...|.:||
Human   180 FGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGD 244

  Fly   260 NLKARFDGATRVQVTNSLRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPD 324
            .|:.|||||:||...|               .|||......|:
Human   245 VLRDRFDGASRVLYGN---------------RGSNRASRAELL---------------------- 272

  Fly   325 ILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKDLVY 389
                                                          :|.|.:|.||||...||||
Human   273 ----------------------------------------------RLEPEDPAHKPPSPHDLVY 291

  Fly   390 LEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVK 454
            .|.||:||..:.|.|..||.||.||.:|..:|||.|:|||||:|.....|.|||.|||||||.|.
Human   292 FEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVS 356

  Fly   455 CKLCRTKKVIYTCL 468
            |:.|...:|::.||
Human   357 CRNCTHTRVLHECL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wg	NP_523502.1	Wnt_Wnt1	64..468	CDD:381707	191/403 (47%)
WNT1	NP_005421.1	Wnt_Wnt1	64..370	CDD:381707	191/403 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3963
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S3860
OMA	1	1.010	-	-		QHG48513
OrthoDB	1	1.010	-	-		D280593at33208
OrthoFinder	1	1.000	-	-		FOG0008365
OrthoInspector	1	1.000	-	-		otm40463
orthoMCL	1	0.900	-	-		OOG6_109161
Panther	1	1.100	-	-	LDO	PTHR12027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4826
SonicParanoid	1	1.000	-	-		X6347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700