DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wg and wnt3

DIOPT Version :9

Sequence 1:	NP_523502.1	Gene:	wg / 34009	FlyBaseID:	FBgn0284084	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001108024.1	Gene:	wnt3 / 569420	ZFINID:	ZDB-GENE-081003-1	Length:	355	Species:	Danio rerio

Alignment Length:	471	Identity:	156/471 - (33%)
Similarity:	213/471 - (45%)	Gaps:	121/471 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDISYI-FVICLMALCSGGSSLSQVEGKQKSGRGRGSMWWGIAKVGEPNNI--TPIMYMD-PAIH 61
            ||:..: |::|:.      .|.|:|.|..       .:||.:|...:.::|  .||:... |.
Zfish     1 MDLYLVGFLMCMW------FSSSRVLGGY-------PIWWSLALGQQYSSIGSQPILCGSIPG-- 50

  Fly    62 STLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRE 126
              |..||.|..|:...::.::.:|..|.|.|||||||.|||||:|...|..  :||.::|:..||
Zfish    51 --LVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIKDSLA--IFGPVLDKATRE 111

  Fly   127 TSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSPQANHQAGSVAGVRDWEWGGCSDNIGF 191
            ::|::||.||.|..::.|:|:|||...|.|| ||....|.           ..|:|||||::..|
Zfish   112 SAFVHAIASAGVAFAVTRSCAEGTSTMCGCD-SHHKGPPG-----------EGWKWGGCSEDAEF 164

  Fly   192 GFKFSREFVDTGERGRNLREKMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRV 256
            |...||||.|..|...:.|..||.|||||||..:...|...|||||:||||.|||||....:||:
Zfish   165 GVLVSREFADARENRPDARSAMNRHNNEAGRMTILENMHLRCKCHGLSGSCEVKTCWWAQPDFRL 229

  Fly   257 IGDNLKARFDGATRVQVTNSLRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDH 321
            :||.||.::|.|:.:.|                                       |:.|
Zfish   230 LGDYLKDKYDSASEMVV---------------------------------------EKHR----- 250

  Fly   322 MPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKD 386
                                         ..||.....|.     :|.|        .|.|..:|
Zfish   251 -----------------------------ESRGWVETLRA-----KYAF--------FKHPTERD 273

  Fly   387 LVYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCC 451
            |||.|.||:|||.|...|..||..|.||.:|.|::||.|:|||||:........|:|.|.|||||
Zfish   274 LVYYEGSPNFCEPNPETGSFGTRDRACNVSSHGIEGCDLLCCGRGHNTRTEKRKEKCHCIFHWCC 338

  Fly   452 EVKCKLCRTKKVIYTC 467
            .|.|:.|.....::||
Zfish   339 YVSCQECVRVYDVHTC 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wg	NP_523502.1	Wnt_Wnt1	64..468	CDD:381707	141/404 (35%)
wnt3	NP_001108024.1	WNT1	47..355	CDD:128408	142/412 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810