DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wg and Wnt6

DIOPT Version :9

Sequence 1:	NP_523502.1	Gene:	wg / 34009	FlyBaseID:	FBgn0284084	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001101696.1	Gene:	Wnt6 / 316526	RGDID:	1304559	Length:	365	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	154/452 - (34%)
Similarity:	213/452 - (47%)	Gaps:	127/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GSMWWGIAKVGEPNNITPIMYMDPAIHSTLRRKQRRLV-------RDNPGVLGALVKGANLAISE 92
            |.:||.   ||.|      :.|||   :::.||.|||.       :..|.|:..|.:||.|.:.|
  Rat    23 GGLWWA---VGSP------LVMDP---TSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRE 75

  Fly    93 CQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRETSFIYAITSAAVTHSIARACSEGTIESCTCD 157
            ||.|||.||||||:.:     ..||:::.:..|||:|::|||:|..:|::.:|||.|.:..|.|.
  Rat    76 CQFQFRFRRWNCSSHS-----KAFGRVLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQ 135

  Fly   158 YSHQSRSPQANHQAGS-----VAGVRD----WEWGGCSDNIGFGFKFSREFVDT-GERGR-NLRE 211
            .......|:.:...|:     ..|..|    ||||||.|::.||.:.||.|:|. .:||| ::|.
  Rat   136 APRGRAPPRPSGLLGTPGPPGPTGSPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRGDIRA 200

  Fly   212 KMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNS 276
            .:.||||||||..|::..|.||||||:||||.::|||.:|..||.:|..|..||.||:||..||.
  Rat   201 LVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTND 265

  Fly   277 LRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNM 341
            .:|.                                                            :
  Rat   266 GKAL------------------------------------------------------------L 270

  Fly   342 PSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRQGIL 406
            |:..:|                                ||||..||:|...||.||..|.|.|..
  Rat   271 PAVRTL--------------------------------KPPGRADLLYAADSPDFCAPNRRTGSP 303

  Fly   407 GTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL 468
            ||.||.||.::..:.||.|:|||||:|::.|.:.|.|.|.|||||.|:|..||.:|.:..||
  Rat   304 GTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLCL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wg	NP_523502.1	Wnt_Wnt1	64..468	CDD:381707	143/421 (34%)
Wnt6	NP_001101696.1	Wnt_Wnt6	35..365	CDD:381712	146/429 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D280593at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820