DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wg and Wnt1

DIOPT Version :9

Sequence 1:	NP_523502.1	Gene:	wg / 34009	FlyBaseID:	FBgn0284084	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_067254.1	Gene:	Wnt1 / 22408	MGIID:	98953	Length:	370	Species:	Mus musculus

Alignment Length:	470	Identity:	207/470 - (44%)
Similarity:	256/470 - (54%)	Gaps:	113/470 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SYIFVICLMALCSGGSSLSQVEGKQKSGRGRGSMWWGIAKVGEPNNI-----TPIMYMDPAIHST 63
            |::....|:||    ::|........|||     ||||..:....|:     :..:.::|:: ..
Mouse     9 SWVSTTLLLAL----TALPAALAANSSGR-----WWGIVNIASSTNLLTDSKSLQLVLEPSL-QL 63

  Fly    64 LRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRETS 128
            |.||||||:|.|||:|.::..|...|:.||:.|||||||||.|   :.|.:||||||:||||||:
Mouse    64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPT---APGPHLFGKIVNRGCRETA 125

  Fly   129 FIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSPQANHQAGSVAGVRDWEWGGCSDNIGFGF 193
            ||:|||||.||||:||:||||:||||||||  :.|.|          |..||.||||||||.||.
Mouse   126 FIFAITSAGVTHSVARSCSEGSIESCTCDY--RRRGP----------GGPDWHWGGCSDNIDFGR 178

  Fly   194 KFSREFVDTGERGRNLREKMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIG 258
            .|.|||||:||:||:||..||||||||||..|.:|||||||||||||||||:||||||...|.:|
Mouse   179 LFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVG 243

  Fly   259 DNLKARFDGATRVQVTNSLRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMP 323
            |.|:.|||||:||...|               .|||......|:
Mouse   244 DVLRDRFDGASRVLYGN---------------RGSNRASRAELL--------------------- 272

  Fly   324 DILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKDLV 388
                                                           :|.|.:|.||||...|||
Mouse   273 -----------------------------------------------RLEPEDPAHKPPSPHDLV 290

  Fly   389 YLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEV 453
            |.|.||:||..:.|.|..||.||.||.:|..:|||.|:|||||:|.....|.|||.|||||||.|
Mouse   291 YFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHV 355

  Fly   454 KCKLCRTKKVIYTCL 468
            .|:.|...:|::.||
Mouse   356 SCRNCTHTRVLHECL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wg	NP_523502.1	Wnt_Wnt1	64..468	CDD:381707	191/403 (47%)
Wnt1	NP_067254.1	WNT1	60..370	CDD:128408	191/408 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3963
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S3860
OMA	1	1.010	-	-		QHG48513
OrthoDB	1	1.010	-	-		D280593at33208
OrthoFinder	1	1.000	-	-		FOG0008365
OrthoInspector	1	1.000	-	-		otm42540
orthoMCL	1	0.900	-	-		OOG6_109161
Panther	1	1.100	-	-	LDO	PTHR12027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4826
SonicParanoid	1	1.000	-	-		X6347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.700