Protein Alignment Wnt4 and WNT8B

DIOPT Version :10

• Sequence 1: NP_476972.2
• Gene: Wnt4 / 34007
• FlyBaseID: FBgn0010453
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_003384.2
• Gene: WNT8B / 7479
• HGNCID: 12789
• Length: 351
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 90/295 - (30%)
• Similarity: 144/295 - (48%)
• Gaps: 45/295 - (15%)

  Fly   274 CEEQFRYDRWNC-----SIETRGKRNIFKKLYKETAFVHALTAAAMTHSIARACAEGRMTKCSCG 333
            |:.||.:|||||     .:.:.|.   .:...:|||||||:::|.:.:::.|.|:.|....|.|.
Human    54 CKYQFAWDRWNCPERALQLSSHGG---LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCD 115

  Fly   334 PKKHNR-EAQDFQWGGCNDNLKHGKRVTRSFLDLRGGDGDEVSEILRHDSEVGIEAVSSQMMDKC 397
            ..::.: ..|.:.||||:||:..|:.:::.|:|......|..:.:..|::|.|.:||...|...|
Human   116 DSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTC 180

  Fly   398 KCHGVSGSCSMKTCWKKMADFNATATLLRQKYNEAIR-----KAPNQRSMRQVSSSRMKKPKQRR 457
            |||||||||:.:|||.::.:|......|::||:.|::     .|.|..:.|...:...:....|.
Human   181 KCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRE 245

  Fly   458 KKPQQSQYTTLYYLETSPSYCAV--------TKDRQCLHPD---------NCGTLC--CGRGYTT 503
                      |.:||.||.||..        |:.|:||...         :|..||  ||.....
Human   246 ----------LVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDCGLAVEE 300

  Fly   504 QVVKQVEKCRCRFNNGRCCQLICDYCQRLENKYFC 538
            :..:.|..|.|:|:  .||.:.|:.|:|...||||
Human   301 RRAETVSSCNCKFH--WCCAVRCEQCRRRVTKYFC 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wnt4	NP_476972.2	Wnt_Wnt9	245..539	CDD:381715	90/295 (31%)
WNT8B	NP_003384.2	Wnt_Wnt8b	30..334	CDD:381726	90/295 (31%)