Protein Alignment Wnt4 and Wnt5

DIOPT Version :10

• Sequence 1: NP_476972.2
• Gene: Wnt4 / 34007
• FlyBaseID: FBgn0010453
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_476924.1
• Gene: Wnt5 / 32838
• FlyBaseID: FBgn0010194
• Length: 1004
• Species: Drosophila melanogaster
• Alignment Length: 714
• Identity: 151/714 - (21%)
• Similarity: 222/714 - (31%)
• Gaps: 306/714 - (42%)

  Fly    42 NPAIHHQQHQQHQQHQQHQQH----QSNHNLNNGNMN---STILNTLMGNNAGQVV--------- 90
            :|....|:.::.||.|:.:..    ||.:      |.   ..|:.|:  ||..:..
  Fly   381 SPKCIRQRRREEQQRQRERDEWFRGQSQY------MQPRFEPIIQTI--NNTKRFAVSIEIPDSF 437

  Fly    91 -NSSPGGGGSMINQLGSSTSSVPSVIGGGVGSVGNPWHSAVGLGVPGN---------GMGLPSS- 144
             .||.|..|.:::::..|..|:.|.......|........:.:.:..|         .:.:.|:
  Fly   438 KVSSEGSDGELLSRVERSQPSISSSSSSSSSSSRKIMPDYIKVSMENNTSVTDYFKHDVVMTSAD 502

  Fly   145 --------------HGLGGNMGSHPHGHALAGLAKLGIIVPGGQGLPGNLGYGGTMLNGGGVGGA 195
                          ||..|:..|| |...                .|....|..|
  Fly   503 VASDREFLIKNMEEHGGAGSANSH-HNDT----------------TPTADAYSET---------- 540

  Fly   196 AGMGLGIGSNTNNMDMQQGLYNEHFISEHTVMAVFTSQGQVGGPCRYMPATRRQNHQCRKETGLP 260
                  |..|.||.....||.|.                              |..||.|.|.:.
  Fly   541 ------IDLNPNNCYSAIGLSNS------------------------------QKKQCVKHTSVM 569

  Fly   261 GTLSEARRLATTHCEEQFRYDRWNCSIETRGKRNIFKKLYK----ETAFVHALTAAAMTHSIARA 321
            ..:|...|.|...|:.||:..|||||  |.....:|..:..    |.||:|||.||.:|..||||
  Fly   570 PAISRGARAAIQECQFQFKNRRWNCS--TTNDETVFGPMTSLAAPEMAFIHALAAATVTSFIARA 632

  Fly   322 CAEGRMTKCSCG----PKK-HNREAQDFQWGGCNDNLKHGKRVTRSFLDLRGGDGD--------- 372
            |.:|::..|||.    ||: |:    |::||||.|||:...:....|:|.|..:.:
  Fly   633 CRDGQLASCSCSRGSRPKQLHD----DWKWGGCGDNLEFAYKFATDFIDSREKETNRETRGVKRK 693

  Fly   373 ----------------------------------------------EVSEILR------------ 379
                                                          |.|.||.
  Fly   694 REEINKNRMHSDDTNAFNIGIKRNKNVDAKNDTSLVVRNVRKSTEAENSHILNENFDQHLLELEQ 758

  Fly   380 ----------------------------------------------------------------- 379
                                                                             
  Fly   759 RITKEILTSKIDEEEMIKLQEKIKQEIVNTKFFKGEQQPRKKKRKNQRAAADAPAYPRNGIKESY 823

  Fly   380 ---------------------HDSEVGIEAVSSQMMDKCKCHGVSGSCSMKTCWKKMADFNATAT 423
                                 |::|.|..||..:....|||||||||||:.|||::::.......
  Fly   824 KDGGILPRSTATVKARSLMNLHNNEAGRRAVIKKARITCKCHGVSGSCSLITCWQQLSSIREIGD 888

  Fly   424 LLRQKYNEAIRKAPNQRSMRQVSSSRMKKPKQRRKKPQQSQYTTLYYLETSPSYC--------AV 480
            .||:||..|.:...|:|...|:...:.|.|...          .|.||:.||.:|        ..
  Fly   889 YLREKYEGATKVKINKRGRLQIKDLQFKVPTAH----------DLIYLDESPDWCRNSYALHWPG 943

  Fly   481 TKDRQCLHP-----DNCGTLCCGRGYTTQVVKQVEKCRCRFNNGRCCQLICDYCQRLENKYFCK 539
            |..|.| |.     ::|..|||||||.|:.:...|:|.|:|:  .|||:.|:.|.::..::.||
  Fly   944 THGRVC-HKNSSGLESCAILCCGRGYNTKNIIVNERCNCKFH--WCCQVKCEVCTKVLEEHTCK 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wnt4	NP_476972.2	Wnt_Wnt9	245..539	CDD:381715	111/468 (24%)
Wnt5	NP_476924.1	Wnt_Wnt5	548..1004	CDD:381711	114/504 (23%)