DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt4 and Wnt2b

DIOPT Version :9

Sequence 1:	NP_001260187.1	Gene:	Wnt4 / 34007	FlyBaseID:	FBgn0010453	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_033546.2	Gene:	Wnt2b / 22414	MGIID:	1261834	Length:	389	Species:	Mus musculus

Alignment Length:	321	Identity:	102/321 - (31%)
Similarity:	168/321 - (52%)	Gaps:	33/321 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 CRYMPA-TRRQNHQCRKETGLPGTLSEARRLATTHCEEQFRYDRWNCSIETRGKRNIFKKLY--- 300
            |..:|. ..||...|::...:..::.|..|.....|:.|||:.||||:...| ...:|.:..
Mouse    70 CDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDR-DHTVFGRAMLRS 133

  Fly   301 -KETAFVHALTAAAMTHSIARACAEGRMTKCSCGP---KKHNREAQDFQWGGCNDNLKHGKRVTR 361
             :|.|||:|:::|.:.|:|.|||::|.::.|||.|   .:|:.:..||.||||:||:.:|.|..:
Mouse   134 SREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAK 198

  Fly   362 SFLDLRGGDGDEVSEILR-HDSEVGIEAVSSQMMDKCKCHGVSGSCSMKTCWKKMADFNATATLL 425
            :|:|.:.....:...::. |::..|..||...:..:||||||||||:::|||:.::||..|...|
Mouse   199 AFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYL 263

  Fly   426 RQKYNEAIRKAPNQRSMRQVSSSRMKKPKQRRKKPQQSQYTTLYYLETSPSYCAV--------TK 482
            |::|:.|::....|......::         |:..:.:..|.|.|.:.||.||.:        |.
Mouse   264 RRRYDGAVQVTATQDGANFTAA---------RQGYRHATRTDLVYFDNSPDYCVLDKAAGSLGTA 319

  Fly   483 DRQCLH----PDNCGTLCCGRGYTTQVVKQVEKCRCRFNNGRCCQLICDYCQRLENKYFCK 539
            .|.|..    .|.|..:||||||.|..|.:|.:|.|:|:  .||.:.|..|:...:.:.||
Mouse   320 GRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFH--WCCAVRCKECRNTVDVHTCK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt4	NP_001260187.1	wnt	246..539	CDD:278536	98/312 (31%)
Wnt2b	NP_033546.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
Wnt2b	NP_033546.2	wnt	72..378	CDD:306592	99/317 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770