Protein Alignment Ndae1 and Slc4a10

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_001229307.1
• Gene: Slc4a10 / 94229
• MGIID: 2150150
• Length: 1136
• Species: Mus musculus
• Alignment Length: 1127
• Identity: 550/1127 - (48%)
• Similarity: 746/1127 - (66%)
• Gaps: 105/1127 - (9%)

  Fly    20 DDEAPKDPRTGGEDFTQ-QFTENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGG 83
            |:||..| |.|.....: .|.:.|.||||  |:::|||||.|.|.|.||.:|.
Mouse    19 DEEAVVD-RGGTRSILKTHFEKEDLEGHR--TLFIGVHVPLGGRKSHRRHRHR------------ 68

  Fly    84 GGGSIGGSGSVGGGAGKDNVSEKQQEVERP-VTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLV 147
                    |.......::..|..:...|.| ...|:||||||||.:.||..|:.|.||:|:..:.
Mouse    69 --------GHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHLPHDLFTELDEIC 125

  Fly   148 -KEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEV 211
             :||::.||:|||||:|||||||:||.|||||:|||||||||||||..::||:|:|||.|..:|.
Mouse   126 WREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEE 190

  Fly   212 MADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNS 276
            :||:|.|..||:|.|...|:.:|.:||:::|.||::.....|:||:||.||:    ..|:.:.||
Mouse   191 IADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLANRIPIVRSFADI----GKKQSEPNS 251

  Fly   277 KHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSE---QQHKGNT------------------- 319
            ......|.:|..:........| .::|..|..:.|:   .|.||:|
Mouse   252 MDKNAGQVVSPQSAPACAENKN-DVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQER 315

  Fly   320 ----HFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGS 380
                |||:|||||||||||||||::||:||:..|:|||.||:|..|.|||:|:||:||||||.|.
Mouse   316 EVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGK 380

  Fly   381 QSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIP 445
            ...:|||||::||||:||:||:|||:|:.|:.|:||:|||||.|||||||||||:||||||..:|
Mouse   381 GQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVP 445

  Fly   446 SQEVRKRPPELPKEEVDEEEEEARLREENG--LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQ 508
            |||.|| .|.:|.......|.|.. ...:|  |.||||:|||||.|||||||::.||::||.|:|
Mouse   446 SQEKRK-IPAVPNGTAAHGEAEPH-GGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQ 508

  Fly   509 CVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVL 573
            |:||::|||.||:||:|||||||.|||...::|:|||....:.|:.|..|.||||||||||||||
Mouse   509 CLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVL 573

  Fly   574 VFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIY 638
            |||.|:::||.:.|..|::.|..||:|.|.:||:|.|.|||:|||||||||||.||:||..||||
Mouse   574 VFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIY 638

  Fly   639 KAIENVMVIGKNFPVNQ-------GIYDCVCTPPIG-SNASVIDYAKYN-------W-----DSC 683
            :|:|.:..:.:.:|:|.       ..|.|.|..|.. ||.::.::.:.|       |     ..|
Mouse   639 EALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNLSASDIIWGNLTVSEC 703

  Fly   684 ESYNGTLVGGDC--GTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIA 746
            .|.:|..||..|  |.|...:|...||:|...|..:|..||:||.:.:||:.||..:|||:|.:.
Mouse   704 RSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLT 768

  Fly   747 IFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQ 811
            |..|...||::|:|:.||:||:..|||...|||.:.| :..||||:.|.|:.||||.||||||||
Mouse   769 ILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTP-LGPNPWWTIIAAIIPALLCTILIFMDQ 832

  Fly   812 QITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAP 876
            ||||||:||||:||||||||||||.::::::.:||:||||||||||||||.||||||||||||||
Mouse   833 QITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAP 897

  Fly   877 GEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIM 941
            ||:|:|||:||||||.::||:.:|.||.:|.:|..||||||:|||||||.:||||:|.||||.:.
Mouse   898 GEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLF 962

  Fly   942 FMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLV 1006
            :||||:|||:::||.||:::|||||:||::||.:||:|| .|:.:|:||:|::.::.:||.:|.:
Mouse   963 WMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIK-VSRAAIVFPMMVLALVFVRKLMDFL 1026

  Fly  1007 FTRRELKILDDIMPEMTKRAAADDLHKL-DAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLSGN 1070
            ||:|||..|||:|||..|:       || |||....|        :....:..|  |:.:||.|:
Mouse  1027 FTKRELSWLDDLMPESKKK-------KLEDAEKEEEQ--------SMLAMEDEG--TVQLPLEGH 1074

  Fly  1071 KTGTKGPTVNIPQEAVNRTAVW 1092
            ...... .:||..| :::||:|
Mouse  1075 YRDDPS-VINISDE-MSKTAMW 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	484/926 (52%)
		Band_3_cyto	167..435	CDD:284893	145/293 (49%)
		HCO3_cotransp	476..968	CDD:279322	285/513 (56%)
Slc4a10	NP_001229307.1	ae	118..1061	CDD:273290	497/966 (51%)
		Band_3_cyto	146..435	CDD:284893	145/293 (49%)
		HCO3_cotransp	476..989	CDD:279322	285/513 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832146
Domainoid	1	1.000	598	1.000	Domainoid score	I199
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1037	1.000	Inparanoid score	I268
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm42883
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840