DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and SLC4A4

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_024310035.1	Gene:	SLC4A4 / 8671	HGNCID:	11030	Length:	1110	Species:	Homo sapiens

Alignment Length:	1148	Identity:	518/1148 - (45%)
Similarity:	712/1148 - (62%)	Gaps:	147/1148 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PWTMNSSSGD---------DEAPKDPRTGGEDFTQQF-TENDFEGHRAHTVYVGVHVPGGRRHSQ 65
            |.|:.:|:.|         |||..|   .|..|.:.. .|.:.|||  ||:|:|||||    .|.
Human    15 PQTIITSTPDTPNFLSWMEDEAVLD---RGASFLKHVCDEEEVEGH--HTIYIGVHVP----KSY 70

  Fly    66 RRRKHHHSGPGGGGGGGGGGGSIGG---------SGSVGGGAGKDNVSEKQQEVERP-VTPPAQR 120
            |||:.|..             ..|.         |.:....:..:|..|....:.:| ::|.|:|
Human    71 RRRRRHKR-------------KTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAER 122

  Fly   121 VQFILGEDVDDGTHVSHPLFSEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLS 184
            ::|||||  :|.:.....||:|:. :|..:|.|:|||||||||||||.||:||.|||||||||||
Human   123 IRFILGE--EDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLS 185

  Fly   185 LHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYA 249
            ||||||||..:..||:|||.||.:|..:.:::.||.:..|.|.|.:||||...|||:||||   .
Human   186 LHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQ---T 247

  Fly   250 KKTRLPIIRSLADM-RNHSSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQ 313
            ||:.|   |||||: :..||:.:..:|..:..||....::|...:...|::        .|..:.
Human   248 KKSNL---RSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDK--------PEKDQL 301

  Fly   314 QHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPP 378
            ::|    ||:|:|..|||||:||||||||:.....|:||.|||:||.||||||||||:||||||.
Human   302 KNK----FMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPK 362

  Fly   379 GSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAA 443
            |...::||||||:|||||||:||::||:|:.|..|::|:|||||.|.|||||||||.||||||.:
Human   363 GKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKS 427

  Fly   444 IPSQEVRKR----------PPELPKE-------EVDEEEEEARLREENGLSRTGRLFGGLINDIK 491
            :||.:.||.          ..:.|.:       ..|.||          |.||||..||||.|||
Human   428 LPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEE----------LQRTGRFCGGLIKDIK 482

  Fly   492 RKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYG 556
            ||||::.||:.|||::|.:::.:|:|.|.::..|||||||.:||......:||.:...|.|..:.
Human   483 RKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFC 547

  Fly   557 FFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYIT 621
            .|:|||||||.|||||||||.:::.|.....:||:.||.|||:|.|.:|::|.|.|||.||.|.|
Human   548 LFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFT 612

  Fly   622 RFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQG-------IYDCVCTPPIGSNASV------- 672
            |||||.|::||:|||||.|.:.::.:...:|:|..       ::.|.|.||..:|.|:
Human   613 RFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLA 677

  Fly   673 -----------------IDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTV 720
                             .|:|..:...|..|.|.|||.:|...|  ::.|||.:|..||:..|..
Human   678 PEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVP--DITLMSFILFLGTYTSSMA 740

  Fly   721 LKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFV 785
            ||:||.:.:||:..|:.||||:::::|......|..:||.|.||.||:|.|||...|||.:|||.
Human   741 LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFG 805

  Fly   786 EKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGL 850
            | ||||..:.|..||||.|||||||||||||||||||:|||||.|||||||.::||:.|||:|.|
Human   806 E-NPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMAL 869

  Fly   851 PWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMP 915
            ||:|||||:||.|::|||:|:|.|||||:|:||||||||||..|:|:..|:||.:.|:|..||||
Human   870 PWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMP 934

  Fly   916 VLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIK 980
            ||:|||||||||||.|:||.||:.::.||.|:|||:::||.||::||||||.:|:.||.:||::|
Human   935 VLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILK 999

  Fly   981 SFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAEDNHHQHPP 1045
            | :..:|:||:|::.::.:||.:|.:|::.:|..|||::||..|:...|:..|        :...
Human  1000 S-TVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKK--------KKKK 1055

  Fly  1046 GSGAGANYNADKSGPTTIHIPLSGNKTGTKGPTVNIPQEAVNR 1088
            ||....|.::|        .|.|     .|.|::.||.:.:.:
Human  1056 GSLDSDNDDSD--------CPYS-----EKVPSIKIPMDIMEQ 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	458/925 (50%)
		Band_3_cyto	167..435	CDD:284893	141/268 (53%)
		HCO3_cotransp	476..968	CDD:279322	268/522 (51%)
SLC4A4	XP_024310035.1	ae	140..1034	CDD:273290	458/925 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142078
Domainoid	1	1.000	70	1.000	Domainoid score	I9541
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm40807
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.650