Protein Alignment Ndae1 and slc4a10a

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_021335416.1
• Gene: slc4a10a / 798983
• ZFINID: ZDB-GENE-100215-3
• Length: 1211
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 578/1201 - (48%)
• Similarity: 758/1201 - (63%)
• Gaps: 165/1201 - (13%)

  Fly    15 NSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGG 79
            :|...|:||..|...........|.:.:.||||  |:|:|||||.||| |.||.:||
Zfish    23 DSERQDEEAVLDRGGTRSMLNTNFEKEELEGHR--TLYIGVHVPLGRR-SHRRHRHH-------- 76

  Fly    80 GGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMG 144
                      |.........:|:.:|..:|.......|:|||||:||.: ||..|:.|.||:|:.
Zfish    77 ----------GHRHRKRSRERDSGTEDGRESPSYTDTPSQRVQFLLGME-DDEEHIPHALFTELD 130

  Fly   145 -MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQN 208
             :.:|||::.||||||||:|||||||:||.|||||:|||||||||||||..::||:|||||.|.:
Zfish   131 EICLKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVMLDMRASS 195

  Fly   209 LEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RNHS---SS 269
            ||.:||:|.|...::|.|...|:.|:::|||::|.||::.....|:||:||.||: |..|   |.
Zfish   196 LEEIADMVLDQHETSGPLGEEVRKKIRNALLKQHHHQNQKKLANRIPIVRSFADIGRKQSEPHSM 260

  Fly   270 KKKKSNSKHSRPA------QNLSSITED---------------MVKSPS------------NQSM 301
            .|..:.:.||.|:      ...||...|               .|.||.            |.|:
Zfish   261 DKNVTTTSHSSPSPCCSFWSRFSSSVRDRQVLLCPDWPLRCPKCVSSPQKLHPCPSATPAPNSSL 325

  Fly   302 AR-----------------------------PGSGTELSEQQHKGNT------------------ 319
            .|                             ..||..:|.|....||
Zfish   326 IRHHKTHIPFSKRLSPPYGYHVIPTLNFEEESPSGQMVSPQTQPINTEGRGEGSRENSAVDFSKI 390

  Fly   320 --HFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQS 382
              |||:|||||||||||||||::|||:.:..|||||.||:|..|.|||:.|||:||||||.|...
Zfish   391 DLHFMKKIPPGAEASNILVGELEFLEKPVVAFIRLSPAVLLNGLAEVPITTRFLFILLGPMGKGP 455

  Fly   383 NFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQ 447
            .:|||||::||||:||:||:|||:|::|..|::|:|||||.||||||||||||||||||..:|||
Zfish   456 QYHEIGRSIATLMTDEVFHDVAYKAKERSDLVAGIDEFLDQVTVLPPGEWDPTIRIEPPKNVPSQ 520

  Fly   448 EVRKRPPELPKEEVDEEEEEARLREENG-----LSRTGRLFGGLINDIKRKAPWYISDYKDALSM 507
            |.||.|| |.....|..|||    |..|     |.||||:||||..|||||||.|:|||.||||:
Zfish   521 EKRKVPP-LANGGADLGEEE----EHGGHGGPELQRTGRIFGGLFLDIKRKAPHYLSDYTDALSL 580

  Fly   508 QCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPV 572
            ||:||::|||.||:||:|||||||.|||...::|:|||....:.|:.|..|:|||||||||||||
Zfish   581 QCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPV 645

  Fly   573 LVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFI 637
            ||||.|:::||.:.|..|::.|..||:|.|..|::|.|.|||:|||||||||||.||:||..|||
Zfish   646 LVFEKILFKFCKEYGLSYLSLRVCIGLWTAFFCLLLVATDASSLVCYITRFTEEAFASLICIIFI 710

  Fly   638 YKAIENVMVIGKNFPVNQ-------GIYDCVCT-PPIGSN------------ASVIDYAKYNWDS 682
            |:|:|.::.:|:.:|.|.       ..|.|||| |...||            ||.||:...:...
Zfish   711 YEALEKLIHLGETYPFNMHNDLNKLTQYSCVCTIPKEPSNATLKYWEEKNITASEIDWLGLDVKG 775

  Fly   683 CESYNGTLVGGDCG--TPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLI 745
            |....|..||..||  .|...:|...||||...|..:|:.|||||.:.:||:.|||.||||:|.|
Zfish   776 CVENRGEFVGSACGHHGPYIPDVLFWSVVLFFSTVAMSSFLKEFKTSRYFPTKVRQIISDFAVFI 840

  Fly   746 AIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMD 810
            .|..|...||.||||:.||:|||..|||...|||:|.| :..||||:.|:...||||.|||||||
Zfish   841 TIMTMVLIDYGLGVPSPKLQVPNVFKPTRDDRGWIISP-LGPNPWWTVIVTCIPALLCTILIFMD 904

  Fly   811 QQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSA 875
            |||||||:||||:|||||||||||||::.:::.:||:||||||||||||||:|||||||||||||
Zfish   905 QQITAVIINRKEHKLKKGCGYHLDLFVVGVMLGVCSVMGLPWFVAATVLSISHVNSLKLESECSA 969

  Fly   876 PGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILI 940
            |||:|:|||:||||.|.::||:.:|.||.:|.:|.:||||||:|||||||.:||:|:|||||:.:
Zfish   970 PGEQPKFLGIREQRFTGLMIFVLMGSSVFMTSVLKHIPMPVLYGVFLYMGASSLRGIQFFDRLKL 1034

  Fly   941 MFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDL 1005
            ..||||:|||:::||.||:::||:||:|||:||::||:||: |:.:|:||:|::.::.|||.||.
Zfish  1035 FGMPAKHQPDFIYLRHVPLRKVHMFTIIQLSCLVLLWVIKT-SRAAIVFPMMVLALVFIRKLLDF 1098

  Fly  1006 VFTRRELKILDDIMPEMTKRAAADDLHKLDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLSGN 1070
            ||::|:|..|||:|||..|:...      ||:...:|.......|           .:.:||.|:
Zfish  1099 VFSKRDLSWLDDLMPESKKKKME------DAQQEENQCVLIEDEG-----------IVQVPLEGH 1146

  Fly  1071 KTGTKGPTVNIPQEAVNRTA---VWQQINKD 1098
            ...... ||||..| :.:|:   ||:.:|.:
Zfish  1147 YKDDPS-TVNITDE-MTKTSFGNVWKGLNPE 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	513/989 (52%)
		Band_3_cyto	167..435	CDD:284893	154/353 (44%)
		HCO3_cotransp	476..968	CDD:279322	296/513 (58%)
slc4a10a	XP_021335416.1	Band_3_cyto	126..1130	CDD:331698	522/1016 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575041
Domainoid	1	1.000	594	1.000	Domainoid score	I196
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I257
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm25027
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940