DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ndae1 and SLC4A2

DIOPT Version :9

Sequence 1:NP_723263.2 Gene:Ndae1 / 34005 FlyBaseID:FBgn0259111 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_001186621.1 Gene:SLC4A2 / 6522 HGNCID:11028 Length:1241 Species:Homo sapiens


Alignment Length:1056 Identity:395/1056 - (37%)
Similarity:587/1056 - (55%) Gaps:94/1056 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 MNSSSGDDEA--PKDPRTGGEDFTQQFTEND-FEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGP 75
            :.|.:|.::|  |:.|....|..|....:.| .:.||..      .|||.|||..|:        
Human   241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFE------DVPGVRRHLVRK-------- 291

  Fly    76 GGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLF 140
                         ...||...|          :|...|...|..|.:         ..|..|.:|
Human   292 -------------NAKGSTQSG----------REGREPGPTPRARPR---------APHKPHEVF 324

  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204
            .|:. :|:.:..|.:|:||||||||||||||...||.|||||:||..||.||||.|.:|:|:||:
Human   325 VELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDL 389

  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLP---IIRSLADMRNH 266
            :.|.|..:|..|.:.||.:..:....:..|..|||.:|.|..: .|....|   ...||..:..|
Human   390 DQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD-EKDFSFPRNISAGSLGSLLGH 453

  Fly   267 SSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEA 331
            ...:..:|:...:.|.  :..:.|..::....:.:..|.....::..:.|.....:.|||..|||
Human   454 HHGQGAESDPHVTEPL--MGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEA 516

  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396
            :.:|||.|:||.|....|:||.:||.|..:.|||||.||:|:||||..:..::|||||:::||||
Human   517 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581

  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPE------ 455
            |:.|||.||.|.:|:.||:.::.|||...||||.|......:...|....|.::||..:      
Human   582 DKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPT 646

  Fly   456 ----LPKEEVD----EEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512
                .||...|    :..|.|...|::.|.||||.|||||.|::|:.|.|:||::|||..||:|:
Human   647 GAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAA 711

  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577
            .||:|||.|||.|||||||.|.|...:...|.::|..:.|:.:.....|||.::|.:||:||||.
Human   712 VIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEE 776

  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642
            ..:.||.....:|:..|.|||.|:..:.:::.|::.|.||.:::|||:|.||.||:.||||:...
Human   777 AFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFY 841

  Fly   643 NVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAK-YNWDSCESY----NGTLVG-GDCGTPPTE 701
            .::.|.:..|    ::.|     ..||:|.:|..: ..|......    |.:|.| ...|.|..:
Human   842 KLVKIFQEHP----LHGC-----SASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ 897

  Fly   702 -NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKL 764
             |..|:|:||.||||.|:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||
Human   898 PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962

  Fly   765 EVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLK 826
            .||:....|. ..|||:|.|..||:|:  |..:.::.||:|..|||||:.|||.:|:::||..|:
Human   963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQ 1027

  Fly   827 KGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVT 891
            ||.|:||||.::..:..||::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||
Human  1028 KGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVT 1092

  Fly   892 HILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQ 956
            .:|:.|.:|:|:::..||..||:.||||:||||||.||.|:||::|:.::.||.|:.||..::::
Human  1093 GLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKK 1157

  Fly   957 VPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILD--DI 1018
            |...|:||||.:||.||.:||.:.| :..|:.||.:|::.:.:|. .|..:||.||:|.||  :.
Human  1158 VRTLRMHLFTALQLLCLALLWAVMS-TAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEA 1221

  Fly  1019 MPEMTKRAAADDLHKL 1034
            .|...:|...|:.:::
Human  1222 EPVFDEREGVDEYNEM 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ndae1NP_723263.2 ae 140..1016 CDD:273290 364/905 (40%)
Band_3_cyto 167..435 CDD:284893 104/270 (39%)
HCO3_cotransp 476..968 CDD:279322 217/502 (43%)
SLC4A2NP_001186621.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..240
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..320 9/71 (13%)
ae 324..1240 CDD:273290 369/927 (40%)
Band_3_cyto 359..620 CDD:284893 100/263 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..471 3/23 (13%)
HCO3_cotransp 675..1167 CDD:279322 215/500 (43%)
Membrane (anion exchange) 708..1241 220/540 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142082
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265068at2759
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100185
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1874
SonicParanoid 1 1.000 - - X102
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.680

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