Protein Alignment Ndae1 and SLC4A2

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_003031.3
• Gene: SLC4A2 / 6522
• HGNCID: 11028
• Length: 1241
• Species: Homo sapiens
• Alignment Length: 1056
• Identity: 395/1056 - (37%)
• Similarity: 587/1056 - (55%)
• Gaps: 94/1056 - (8%)

  Fly    14 MNSSSGDDEA--PKDPRTGGEDFTQQFTEND-FEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGP 75
            :.|.:|.::|  |:.|....|..|....:.| .:.||..      .|||.|||..|:
Human   241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFE------DVPGVRRHLVRK-------- 291

  Fly    76 GGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLF 140
                         ...||...|          :|...|...|..|.:         ..|..|.:|
Human   292 -------------NAKGSTQSG----------REGREPGPTPRARPR---------APHKPHEVF 324

  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204
            .|:. :|:.:..|.:|:||||||||||||||...||.|||||:||..||.||||.|.:|:|:||:
Human   325 VELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDL 389

  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLP---IIRSLADMRNH 266
            :.|.|..:|..|.:.||.:..:....:..|..|||.:|.|..: .|....|   ...||..:..|
Human   390 DQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD-EKDFSFPRNISAGSLGSLLGH 453

  Fly   267 SSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEA 331
            ...:..:|:...:.|.  :..:.|..::....:.:..|.....::..:.|.....:.|||..|||
Human   454 HHGQGAESDPHVTEPL--MGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEA 516

  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396
            :.:|||.|:||.|....|:||.:||.|..:.|||||.||:|:||||..:..::|||||:::||||
Human   517 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581

  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPE------ 455
            |:.|||.||.|.:|:.||:.::.|||...||||.|......:...|....|.::||..:
Human   582 DKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPT 646

  Fly   456 ----LPKEEVD----EEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512
                .||...|    :..|.|...|::.|.||||.|||||.|::|:.|.|:||::|||..||:|:
Human   647 GAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAA 711

  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577
            .||:|||.|||.|||||||.|.|...:...|.::|..:.|:.:.....|||.::|.:||:||||.
Human   712 VIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEE 776

  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642
            ..:.||.....:|:..|.|||.|:..:.:::.|::.|.||.:::|||:|.||.||:.||||:...
Human   777 AFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFY 841

  Fly   643 NVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAK-YNWDSCESY----NGTLVG-GDCGTPPTE 701
            .::.|.:..|    ::.|     ..||:|.:|..: ..|......    |.:|.| ...|.|..:
Human   842 KLVKIFQEHP----LHGC-----SASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ 897

  Fly   702 -NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKL 764
             |..|:|:||.||||.|:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||
Human   898 PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962

  Fly   765 EVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLK 826
            .||:....|. ..|||:|.|..||:|:  |..:.::.||:|..|||||:.|||.:|:::||..|:
Human   963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQ 1027

  Fly   827 KGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVT 891
            ||.|:||||.::..:..||::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||
Human  1028 KGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVT 1092

  Fly   892 HILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQ 956
            .:|:.|.:|:|:::..||..||:.||||:||||||.||.|:||::|:.::.||.|:.||..::::
Human  1093 GLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKK 1157

  Fly   957 VPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILD--DI 1018
            |...|:||||.:||.||.:||.:.| :..|:.||.:|::.:.:|. .|..:||.||:|.||  :.
Human  1158 VRTLRMHLFTALQLLCLALLWAVMS-TAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEA 1221

  Fly  1019 MPEMTKRAAADDLHKL 1034
            .|...:|...|:.:::
Human  1222 EPVFDEREGVDEYNEM 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	364/905 (40%)
SLC4A2	NP_003031.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..240
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..320		9/71 (13%)
		ae	324..1240	CDD:273290	369/927 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..471		3/23 (13%)
		Membrane (anion exchange)	708..1241		220/540 (41%)