DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and SLC4A1

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_000333.1	Gene:	SLC4A1 / 6521	HGNCID:	11027	Length:	911	Species:	Homo sapiens

Alignment Length:	970	Identity:	345/970 - (35%)
Similarity:	538/970 - (55%)	Gaps:	100/970 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KDNVSE--KQQEVERPVTPPAQRVQFILGEDVD----DGTHVSHP----LFSEMGMLV--KEGDE 152
            :|.:.|  :|:|.|.|..|.:| ::.....|.:    |....|||    ::.|:..||  ::..|
Human     9 EDMMEENLEQEEYEDPDIPESQ-MEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQE 72

  Fly   153 IEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVC 217
            :.|.|.|||::.||::.|.| .|.:||::.|:..||.||||:...|:|:||::..:|..:|:.:.
Human    73 LRWMEAARWVQLEENLGENG-AWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLL 136

  Fly   218 DHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKHSRPA 282
            |..:....:.|..::::..|||.:|.|..|         :.:|..:       |....::...|:
Human   137 DRFIFEDQIRPQDREELLRALLLKHSHAGE---------LEALGGV-------KPAVLTRSGDPS 185

  Fly   283 QNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTH------FMRKIPPGAEASNILVGEVDF 341
            |.|         .|.:.|:.     |:|..:|..|.|.      .:.||||.:||:.:|||..||
Human   186 QPL---------LPQHSSLE-----TQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADF 236

  Fly   342 LERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYR 406
            ||:.:..|:||.:|..| :..|:|||.||:|:||||.....::.::|||.|||||:.:|...||.
Human   237 LEQPVLGFVRLQEAAEL-EAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYM 300

  Fly   407 ARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLR 471
            |:.|..||..::.|||...||||.:......:.....:..:.:|:|....|.:......:...|.
Human   301 AQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLN 365

  Fly   472 --EENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEA 534
              .::.|.:||:|||||:.||:|:.|:|:||..||.|.|.:|:.||:|||.|||.|||||||.|.
Human   366 GGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEK 430

  Fly   535 TGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGM 599
            |...|...|.|:|..|.|:.:.....|||.::|.:||:||||...:.||...|.:|:..|.|||.
Human   431 TRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGF 495

  Fly   600 WVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTP 664
            |:..:.:::.|.:.|.||.:|:|:|:|.|:.||:.||||:....::.|.::.|:.:
Human   496 WLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQK--------- 551

  Fly   665 PIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALF 729
                        .||      ||..:|....|  |..|..|:|:||.||||..:.:|::|||:.:
Human   552 ------------TYN------YNVLMVPKPQG--PLPNTALLSLVLMAGTFFFAMMLRKFKNSSY 596

  Fly   730 FPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKLEVPNELK-PTLSTRGWLIPPFVEKN--PW 790
            ||..:|:.|.||.|.|:|..|...|:.: ...||||.||:..| ...|.|||:|.|...::  |.
Human   597 FPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPI 661

  Fly   791 WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVA 855
            |....:..||||..||||::.|||.:||::.|.|:.||.|:||||.::..:..:.::.|:||..|
Human   662 WMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSA 726

  Fly   856 ATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGV 920
            .||.|:.|.|:|.:..:.|.||...|...|:|||::.:|:.:.:|:|:|:.|:|..||:.||||:
Human   727 TTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGI 791

  Fly   921 FLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQT 985
            ||||||.||.|:|.|||||::|.|.||.||..::::|...|:||||.||:.||.:||::|| :..
Human   792 FLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKS-TPA 855

  Fly   986 SILFPLMLVVMIGIRKA-LDLVFTRRELKILDDIMPEMTKRAAADDLH-KLDAEDNHHQH 1043
            |:..|.:|::.:.:|:. |.|:|...||:.||           |||.. ..|.|:...::
Human   856 SLALPFVLILTVPLRRVLLPLIFRNVELQCLD-----------ADDAKATFDEEEGRDEY 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	325/890 (37%)
		Band_3_cyto	167..435	CDD:284893	89/273 (33%)
		HCO3_cotransp	476..968	CDD:279322	204/495 (41%)
SLC4A1	NP_000333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/31 (29%)
		Globular	55..290		84/266 (32%)
		ae	58..910	CDD:273290	332/920 (36%)
		Interaction with ANK1. /evidence=ECO:0000305	176..185		0/8 (0%)
		Dimerization arm	304..357		13/52 (25%)
		Involved in anion transport	559..630		27/72 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.680