Protein Alignment Ndae1 and SLC4A3

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_001313488.2
• Gene: SLC4A3 / 6508
• HGNCID: 11029
• Length: 1259
• Species: Homo sapiens
• Alignment Length: 1284
• Identity: 415/1284 - (32%)
• Similarity: 601/1284 - (46%)
• Gaps: 309/1284 - (24%)

  Fly     9 ELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVH---------------VP 58
            :|..|:..|...|...|.|....|..::.::|.|||.|| ||.:...|               .|
Human    37 DLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHR-HTSHHTHHPLSARLPPPHKLRRLPP 100

  Fly    59 GGRRHSQRRRKHHH-SGPGGGGGGGGGGGSIGGSGSV--GGGAGKDNVSEKQQEVE-----RPVT 115
            ...||::|:||... |.|..           .|:..:  .||||.|...|:::|.|     .||.
Human   101 TSARHTRRKRKKEKTSAPPS-----------EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVE 154

  Fly   116 PP----AQRVQFILGEDVDD-----------------GTHVS----------------------- 136
            ||    .|:.:|.:|.|.||                 |.|..
Human   155 PPHSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLA 219

  Fly   137 ----------------------------------------------------------------- 136
                                                                             
Human   220 LSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAE 284

  Fly   137 -------------------------------------------------------------HPLF 140
                                                                         |.:|
Human   285 AQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVF 349

  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204
            .|:. :::....|..|:||||||||||||||...||.|||||:||..||.||||.:.:|:.:||:
Human   350 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDL 414

  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSS 269
            |...|..:|.||.:.|:.:..:.|..:..|...||.:|.|.::.......|        ||.|||
Human   415 EQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFP--------RNPSSS 471

  Fly   270 KKKK-SNSKHSRPAQN----LSSITEDMVK---------SPSNQSMARPGSGTELSEQQHKGNT- 319
            .... ..:.|..|:..    :.::.:|:.:         ....:.:..||.      ..|:|.:
Human   472 SMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGG------DGHRGKSL 530

  Fly   320 HFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNF 384
            ..:.|||..|||:.:|||.|.|||:..:.|:||::||:|..:.|||||.||:|::|||..:.:::
Human   531 KLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY 595

  Fly   385 HEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEV 449
            ||:||::||||||::|||.||:|..|..|||.:.||||...|:||.|.:....:...||...:.:
Human   596 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660

  Fly   450 RKRPPELPKEEVDEEEEEARLR---------------------EENGLSRTGRLFGGLINDIKRK 493
            |||      .|.::.:.|...|                     |::.|.|||.:||||:.|::|:
Human   661 RKR------REREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRR 719

  Fly   494 APWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFF 558
            .|.|.||.:|||..||||:.:|:|||.|||.|||||||.|.|...|...|.:||..|.|:.:...
Human   720 YPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLL 784

  Fly   559 SGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRF 623
            ..|||.::|.:||:||||...::||.....:|:|.|.|:|:|:....:.|.|.:.|.||.||:.|
Human   785 GAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPF 849

  Fly   624 TEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYNWDSCESYNG 688
            |:|.||.||:.||||:....:..:....|: ...|     ||.|:....:|...       ..||
Human   850 TQEIFAFLISLIFIYETFYKLYKVFTEHPL-LPFY-----PPEGALEGSLDAGL-------EPNG 901

  Fly   689 TLVGGDCGTPPTE---------NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVL 744
            :.:      ||||         |..|:|::|..|||.|:..|::|:|:.|.....|:.|.||.:.
Human   902 SAL------PPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960

  Fly   745 IAIFAMSFFDYSL-GVPTQKLEVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTI 805
            |:|..|...|||: ...||||.||..|..|. ..|.|.|||.....|:  |..:.|..||||..|
Human   961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLI 1025

  Fly   806 LIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLE 870
            ||||:.||||:||::|..:|.||.|:||||.::..|..:|.:.||||..||||.|:.|||:|.:.
Human  1026 LIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVM 1090

  Fly   871 SECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFF 935
            ....|||:|||...|||||||.:||...:|:|:::..:|..||:.||||:||||||.||.|:|..
Human  1091 RTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS 1155

  Fly   936 DRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIR 1000
            .|:|::.||||:.|:..::.:|...|:||||.|||.|:.:||::|| :..|:.||.:|::.:.:|
Human  1156 QRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKS-TAASLAFPFLLLLTVPLR 1219

  Fly  1001 KA-LDLVFTRRELKILD--DIMPEMTKRAAADDLHKLDAEDNHHQ-HPP 1045
            .. |..:|..|||:.||  |..|...:          |.:|.::: |.|
Human  1220 HCLLPRLFQDRELQALDSEDAEPNFDE----------DGQDEYNELHMP 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	361/926 (39%)
		Band_3_cyto	167..435	CDD:284893	105/282 (37%)
		HCO3_cotransp	476..968	CDD:279322	215/504 (43%)
SLC4A3	NP_001313488.2	PHA03307	2..>292	CDD:223039	45/266 (17%)
		ae	349..1258	CDD:273290	368/958 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680