DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ndae1 and Slc4a8

DIOPT Version :9

Sequence 1:NP_723263.2 Gene:Ndae1 / 34005 FlyBaseID:FBgn0259111 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_067505.2 Gene:Slc4a8 / 59033 MGIID:1928745 Length:1089 Species:Mus musculus


Alignment Length:1148 Identity:563/1148 - (49%)
Similarity:751/1148 - (65%) Gaps:115/1148 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LPWTMNSSSG-------DDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGGRRHSQRR 67
            :|...|...|       |:||..|...........:.:.:.||||  |:||||.:|.||:..:..
Mouse     1 MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLGRQSHRHH 63

  Fly    68 RKH--HHSGPGGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVD 130
            |.|  .|...||.|.|...|                   |:..|.....| |:||||||||.: :
Mouse    64 RTHGQKHRRRGGRGKGASQG-------------------EEGLEALAHDT-PSQRVQFILGTE-E 107

  Fly   131 DGTHVSHPLFSEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRL 194
            |..||.|.||:|:. :.:|||::.||||||||:|||||||:||.|||||:|||||||||||||..
Mouse   108 DEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172

  Fly   195 LVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRS 259
            |:||||:|||.|.::|.::||:.|.......|...|:.||::|||::|.||:|..:...:||:||
Mouse   173 LINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRS 237

  Fly   260 LADMRNHSSSKKKKSNSKHS--RPAQNLS--SITEDMVKSPSNQSMARPGSGTELSEQQHKGNTH 320
            .|::       .||.:..||  |..|.:|  |.|...||:..|..    .|..:||    |.:.|
Mouse   238 FAEV-------GKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCE----HSPVDLS----KVDLH 287

  Fly   321 FMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFH 385
            ||:|||.||||||:||||||.|:|.:..|:|||.||:|..|||||:||||:||||||.|....:|
Mouse   288 FMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYH 352

  Fly   386 EIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVR 450
            ||||:|||:|:|||||:|||:|::||.||:|:|||||.|||||||||||:||||||..:||||.|
Mouse   353 EIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKR 417

  Fly   451 KRPPELPKEEVDEEEEEARLREENG--LSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASW 513
            |. |.:|...|...|.|.. ...:|  |.|||||||||:.|:|||||||.|||:||||:||:||:
Mouse   418 KM-PGVPNGNVCHIEPEPH-GGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASF 480

  Fly   514 IFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESI 578
            :|||.||:||:|||||||.|||...::|:|||....:.|:.|..|:|||||||||||||||||.|
Mouse   481 LFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKI 545

  Fly   579 IYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIEN 643
            :::||......|::.|..||:|.|.:||||.|.|||:|||||||||||.||:||..||||:|||.
Mouse   546 LFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEK 610

  Fly   644 VMVIGKNFPVNQ-------GIYDCVCTPPIGSNASVIDY--------AKYNW-----DSCESYNG 688
            ::.:.:.:|::.       .:|.|.|..|...|...:.|        |:.||     ..|:..:|
Mouse   611 LIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHG 675

  Fly   689 TLVGGDCG--TPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMS 751
            ..:|..||  .|.|.:|...|.:|...||::|:.||.||.:.:||:.||..:|||:|.:.||.|.
Mouse   676 EFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMV 740

  Fly   752 FFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAV 816
            ..|:.:|||:.||:|||..|||...|||.|.| :..||||:.|.|:.||||.|||||||||||||
Mouse   741 VLDFLIGVPSPKLQVPNVFKPTRDDRGWFINP-IGPNPWWTVIAAIIPALLCTILIFMDQQITAV 804

  Fly   817 IVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQ 881
            |:||||:||||||||||||.::::::.:||:||||||||||||||.||||||||||||||||:|:
Mouse   805 IINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPK 869

  Fly   882 FLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAK 946
            |||:||||||.::||:.:|.||.:|.:|..||||||:||||||||:||:|:|||||:.:..||||
Mouse   870 FLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAK 934

  Fly   947 YQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRE 1011
            :|||:::||.||:::|||||::||.||::||:||: |..:|:||:|::.::.:||.:||.|::||
Mouse   935 HQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKA-SPAAIVFPMMVLALVFVRKVMDLCFSKRE 998

  Fly  1012 LKILDDIMPEMTKRAAADDLHKLDAEDNHHQHPPGS--------------GAGANYNADKSGPTT 1062
            |..|||:||| :|:...||..|.:.|:.......|.              |..:::..|.|    
Mouse   999 LSWLDDLMPE-SKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPS---- 1058

  Fly  1063 IHIPLSGNKTGTKGPTVNIPQEAVNRTAVWQQINKDGNGISEQ 1105
                           .:||..| :.:|.||:.::.:.....|:
Mouse  1059 ---------------EINISDE-MPKTTVWKALSINSGNTKEK 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ndae1NP_723263.2 ae 140..1016 CDD:273290 497/904 (55%)
Band_3_cyto 167..435 CDD:284893 149/271 (55%)
HCO3_cotransp 476..968 CDD:279322 291/513 (57%)
Slc4a8NP_067505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..90 12/53 (23%)
ae 117..1003 CDD:273290 497/904 (55%)
Band_3_cyto 145..402 CDD:284893 149/271 (55%)
HCO3_cotransp 443..956 CDD:279322 291/513 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832147
Domainoid 1 1.000 598 1.000 Domainoid score I199
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1037 1.000 Inparanoid score I268
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45639
OrthoDB 1 1.010 - - D138594at33208
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 1 1.000 - - otm42883
orthoMCL 1 0.900 - - OOG6_100185
Panther 1 1.100 - - LDO PTHR11453
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1874
SonicParanoid 1 1.000 - - X102
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.840

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