Protein Alignment Ndae1 and SLC4A5

DIOPT Version :10

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_067019.3
• Gene: SLC4A5 / 57835
• HGNCID: 18168
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1191
• Identity: 491/1191 - (41%)
• Similarity: 691/1191 - (58%)
• Gaps: 211/1191 - (17%)

  Fly    42 DFEGHRAH--------TVYVGVHVPGGRRHSQRR--RKHHHSG------------PGGGGGGGGG 84
            |...||..        .:::|:.||   .:.||:  :|.|.||            |
Human    14 DHTNHRRRFPDQKECPPIHIGLPVP---TYPQRKTDQKGHLSGLQKVHWGLRPDQP--------- 66

  Fly    85 GGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKE 149
                 .....|.|:|..:.......:.|..:|.|:::|.||||: |:..:.:  ||:||..|..:
Human    67 -----QQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEE-DEAPNPT--LFTEMDTLQHD 123

  Fly   150 GDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMAD 214
            ||::||||:||||||||.|||||.|||||||:|||||||||||..|..|:|:||:::.:|..:.|
Human   124 GDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIID 188

  Fly   215 LVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RNHSSSKKKKSNSKH 278
            .|.:..:..|.|.|.::::|...||||||||      |:.||.|||||: ::.|::.:..:.|..
Human   189 DVIEKQIEDGLLRPELRERVSYVLLRRHRHQ------TKKPIHRSLADIGKSVSTTNRSPARSPG 247

  Fly   279 SRPAQNLSSITEDM-VKSPSN-----QSMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVG 337
            :.|  :|...|||: ::..:|     .:.:|..:...|:....:....||:|||..:||||:|||
Human   248 AGP--SLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVG 310

  Fly   338 EVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHE 402
            |||||::....|:||.|:.:||.:|||||||||:||||||.|...:::|||||:||||.|::|.:
Human   311 EVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSD 375

  Fly   403 VAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKR--------------- 452
            |||:||.|:.|::|:|||||.|.|||||||||.||||||..:||.:.||.
Human   376 VAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVG 440

  Fly   453 ----------------------------------PPELP-KEEVDEEEEEARLREENGLSRTGRL 482
                                              ..|:| ..|:.||           |..|||.
Human   441 GGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEE-----------LIWTGRF 494

  Fly   483 FGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVS 547
            ||||..|||||.||:.||:.|...:|.:::.:|:|..|::..|||||||.:||..:...|||.:.
Human   495 FGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLG 559

  Fly   548 GFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAID 612
            ..:.|..:..||||||.||.||||:|:||.::::|....|.|||.||.|||:..|..|::|.|.|
Human   560 TAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATD 624

  Fly   613 ASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGI-------YDCVCTPPIGSNA 670
            ||.::.||||||||.|:|||:|||||.||:.::...|.:|:|...       |.|.|..|...|.
Human   625 ASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNT 689

  Fly   671 SV-----------------------IDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCA 712
            :|                       :|::..:...|.||.|.|:|..|...|  ::.|||.:|..
Human   690 TVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIP--DLALMSFILFF 752

  Fly   713 GTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTR 777
            ||:.::..||:||.:.:||:.||..::|||::.:|......|...|:.|.||.||:.:|||...|
Human   753 GTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDR 817

  Fly   778 GWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILI 842
            ||.:.|| .|||||....::.||||.||||||||||||||||||||||||..|||||||.:.||:
Human   818 GWFVAPF-GKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILM 881

  Fly   843 AICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTP 907
            |:||.|||||:|||||:||.|::|||:|:|.|||||:||||||||||||.|::|:..|:||.|.|
Human   882 ALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAP 946

  Fly   908 LLGNIPMPVLFGVFLYMGVASLKGLQ----------------FFDRILIMFMPAKYQPDYMFLRQ 956
            :|..||:|||:|||||||||||.|:|                |::|..:..||||:|||:.|||.
Human   947 ILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRH 1011

  Fly   957 VPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPE 1021
            ||::|:||||::|:.||.:||::|| :..:|:||:|::.:|.:|:.||.:|::.:|..:|:|:||
Human  1012 VPLRRIHLFTLVQILCLAVLWILKS-TVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPE 1075

  Fly  1022 ----------MTKRAAADDLHKLDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPLSGNKTGTKG 1076
                      ..|:.|.:|.      |...|.||              |:.|.||:...::.
Human  1076 KEKKETDKKRKRKKGAHEDC------DEEPQFPP--------------PSVIKIPMESVQSD--- 1117

  Fly  1077 PTVNIPQEAVN-----RTAVW 1092
                 ||..::     |::.|
Human  1118 -----PQNGIHCIARKRSSSW 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	446/978 (46%)
SLC4A5	NP_067019.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..94		5/43 (12%)
		Band_3_cyto	114..1070	CDD:452680	446/978 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..255		11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..478		0/39 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1079..1137		15/83 (18%)