DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndae1 and slc4a2b

DIOPT Version :9

Sequence 1:	NP_723263.2	Gene:	Ndae1 / 34005	FlyBaseID:	FBgn0259111	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001107912.1	Gene:	slc4a2b / 570716	ZFINID:	ZDB-GENE-030429-14	Length:	1232	Species:	Danio rerio

Alignment Length:	1112	Identity:	400/1112 - (35%)
Similarity:	585/1112 - (52%)	Gaps:	173/1112 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PWTMNSSSGDDEAPKDP----------------------RTGGEDFTQQ---------------F 38
            |....|:...:.||..|                      |||....|:|               .
Zfish   194 PQDSTSTEASEAAPASPSTAEHGSIPRVSSRSYDLQERRRTGNMTGTEQAKYQRIPTDEYEARTL 258

  Fly    39 TENDFEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGPGGGGGGGGGGGSIGGSGSVGG---GAGK 100
            ...|.:|.::|..   ..|||.|||..|:                         |..|   ...|
Zfish   259 ASADLDGIKSHRF---EDVPGVRRHLVRK-------------------------STKGQMVHISK 295

  Fly   101 DNV--SEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKE-GDEIEWKETARWI 162
            |:.  |.:.::::|  ||                    |.:|.|:..|:.: ..|::|:||||||
Zfish   296 DHKERSTRSRKLDR--TP--------------------HEVFVELNELIMDKNQEMQWRETARWI 338

  Fly   163 KFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLP 227
            ||||||||..:||.|||||:||..||.|||:.:.:|:|:||::.:.|..::..|.:.|:.:..:.
Zfish   339 KFEEDVEEETDRWGKPHVASLSFRSLLELRKTIAHGAVLLDLDQKTLPGISHQVVEQMIISDQIK 403

  Fly   228 PGVKDKVKDALLRRHRH-QHEYAKKTRLPIIRSLADMRNHSSSKKKKSNSKHSRPAQNLSSITED 291
            ...:..|..|||.:|.| ..|....|..|        ||.|::......|.|...:.:| :|.|.
Zfish   404 AEDRANVLRALLLKHSHPSDEKEHITSFP--------RNISAASLGSLISHHQSSSNHL-TIPET 459

  Fly   292 MVKSP------------------SNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVGE 338
            .|..|                  .|:..:....|...|:.:|:  ...:.|||..|||:.:|||.
Zfish   460 SVMEPLMGSSRASQDSTVHIDIDKNEKDSATPIGMHRSKSKHE--LKLLEKIPENAEATVVLVGS 522

  Fly   339 VDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEV 403
            |||||:....|:||.:||.|..:.|||||.||:|:|||||.:..::|:|||:::|||||:.|||.
Zfish   523 VDFLEQPTMAFVRLQEAVELDSVLEVPVPVRFLFVLLGPPSTNMDYHQIGRSISTLMSDKQFHEA 587

  Fly   404 AYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPE----LPKEEVDEE 464
            ||.|..|..||:.::.|||...||||.|......:...|....:.:|||..:    :.||....:
Zfish   588 AYLADDRQDLLNAINGFLDCSIVLPPSELGGEDLLRSVAHFQREMLRKREEQGVALMAKEPKSLQ 652

  Fly   465 EEEARLR----EENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPII 525
            |:||.|.    |::.|.||||||||||.|.:|:.|.||||::|||:.||:|:.||:|||.|||.|
Zfish   653 EKEALLAPFKPEDDPLKRTGRLFGGLIRDAQRRYPKYISDFRDALNPQCMAAVIFIYFAALSPAI 717

  Fly   526 TFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDY 590
            ||||||.|.|...:...|.:|:..|.|:.:.....|||.|:|.:||:||||...:.||.....:|
Zfish   718 TFGGLLGEKTEGLLGVSELIVATCVQGVLFCLLGAQPLLIVGFSGPILVFEEAFFSFCKGNNMEY 782

  Fly   591 MTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIEN------------ 643
            :|.|.|||.|:..|.:::.|.:.|.:|.:::|||:|.|:.||:.||||:....
Zfish   783 LTGRVWIGFWLIIIVVLMVAFEGSFMVRFVSRFTQEIFSFLISLIFIYETFSKLAKIFQEHPLQR 847

  Fly   644 ---VMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFL 705
               |:|..:|..:|..:.:...:|...:|:|..:..|.                .|.|   |..|
Zfish   848 CSAVLVDVRNSSLNSSMDEVTESPLAVTNSSSQEVLKV----------------VGEP---NTAL 893

  Fly   706 MSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKLEVPNE 769
            :|:||.:|||||:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||.||..
Zfish   894 LSLVLMSGTFLIAFYLRKFKNSAFFPGRLRRVIGDFGVPIAILIMVLVDYSVKDTYTQKLSVPRG 958

  Fly   770 LKPTL-STRGWLIPPFVEKN--PWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGY 831
            ...|. ..|||::.|.....  |.|....::.||||..|||||:.|||.:||::||..|.||.|:
Zfish   959 FSVTSPDKRGWIVNPLGSDGQFPIWMMFASILPALLVFILIFMETQITTLIVSKKERMLVKGSGF 1023

  Fly   832 HLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIF 896
            ||||.::..|....::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||.:|:.
Zfish  1024 HLDLLLIVTLGGTSALFGLPWMAAATVRSVTHANALTVMSKAVAPGDKPRIQEVKEQRVTGLLVA 1088

  Fly   897 LTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKR 961
            :.:|:|:::..||..||:.||||:||||||.||.|:|..:|||::.||.||.||:.::|:|...|
Zfish  1089 ILVGLSIVIGDLLRQIPIAVLFGIFLYMGVMSLNGIQMTERILLLLMPPKYHPDHTYVRKVRTLR 1153

  Fly   962 VHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKIL--DDIMPEMT 1023
            :||||.||:.||.:||.:.| :..|:.||.:|::.:.::. .|..:|:.||::.|  ||..|...
Zfish  1154 MHLFTAIQVVCLAVLWAVMS-TVASLAFPFVLIMTVPVKMFLLPRIFSNREMQCLDADDAEPTFD 1217

  Fly  1024 KRAAADD 1030
            ::...|:
Zfish  1218 EKEGQDE 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	367/925 (40%)
		Band_3_cyto	167..435	CDD:284893	107/286 (37%)
		HCO3_cotransp	476..968	CDD:279322	218/510 (43%)
slc4a2b	NP_001107912.1	ae	315..1231	CDD:273290	371/941 (39%)
		Band_3_cyto	343..615	CDD:284893	106/282 (38%)
		HCO3_cotransp	668..1160	CDD:279322	218/510 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.780