Protein Alignment Ndae1 and slc4a7

DIOPT Version :9

• Sequence 1: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_021322675.1
• Gene: slc4a7 / 568872
• ZFINID: ZDB-GENE-140106-104
• Length: 1285
• Species: Danio rerio
• Alignment Length: 1298
• Identity: 581/1298 - (44%)
• Similarity: 766/1298 - (59%)
• Gaps: 250/1298 - (19%)

  Fly    16 SSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVHVPGG----RRHSQRRRKHHHSGPG 76
            ||..||||..|......:....|.:.:.|.|||  ||||||||.|    |||..|..|||..
Zfish    20 SSGNDDEAVVDQGKTSSNIHTNFEKEELESHRA--VYVGVHVPLGRQSRRRHRHRGHKHHRK--- 79

  Fly    77 GGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPV-TPPAQRVQFILGEDVDDGTHVSHPLF 140
                                  .||..||::...:.|. ..|:||||||||.:.||..|:.|.||
Zfish    80 ----------------------RKDRCSEREDGRDSPTYDTPSQRVQFILGTEDDDEEHIPHDLF 122

  Fly   141 SEMGML-VKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204
            :|:..| .::|...||||||||:|||||||:||.|||||:|||||||||||||..::||:|||||
Zfish   123 TELDELCFRDGLTCEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVMLDM 187

  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADM-RNHS- 267
            .|.::|.:||:|.|:||::..|...|::||:||:|:||.||:|.....|:|::||.||: :.||
Zfish   188 RANSIEEIADMVLDNMVASEQLDESVREKVRDAVLKRHHHQNEKKLSNRIPLVRSFADIGKKHSD 252

  Fly   268 -----------------------------SSKKKKSNSKHSRPA----QNLSSITEDMVKSPSNQ 299
                                         ||::....|::||.:    |.|||.......:|.|.
Zfish   253 PHLLERNGEGLSTSRLSLLRRTSSTSTPPSSRRPSRESRYSRSSIILNQLLSSANSTPSTTPQNS 317

  Fly   300 ---------SMARPG---SGTEL------------------------------------------ 310
                     |:..||   .|.||
Zfish   318 PPTAHRASPSLRPPGPSQQGPELLVARGDRDDIPEVVVFPPEEDVGDPLPAFYAVQDEKVVHDPT 382

  Fly   311 --------------------------SEQQHKG-------------------------------- 317
                                      ||.:..|
Zfish   383 RLLPLPQSGLLASPQSAPGILENSKSSESRINGTGGSRENSTVDFSRDSQSPFHCSCGSLGVGTK 447

  Fly   318 ----NTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPP 378
                :.:||:||||||||||:||||||||||.:..|||||.||:|..||||||||||:|:||||.
Zfish   448 RPAVDMNFMKKIPPGAEASNVLVGEVDFLERPIIAFIRLSPAVLLTGLTEVPVPTRFLFLLLGPF 512

  Fly   379 GSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAA 443
            |..:.:|||||::||||:|||||:|||:|:.|:.||||:|||||.||||||||||||||||||.:
Zfish   513 GKGAQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPTIRIEPPKS 577

  Fly   444 IPSQEVRKRPP----ELPKEEVDEEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDA 504
            :||||.||.|.    ..|:.:|.::|......|   |.||||:||||:.|:|||||:|.||.:||
Zfish   578 VPSQEKRKMPSMPNGSTPQSDVIKQEAHHAGPE---LQRTGRIFGGLVLDLKRKAPFYWSDVRDA 639

  Fly   505 LSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGST 569
            .|:||:||.:|||.||:||:|||||||.|||..:::|:|||....:.|:.:..|:||||||||||
Zfish   640 FSLQCLASILFLYCACMSPVITFGGLLGEATKNNISAIESLFGASLTGVAFSLFAGQPLTILGST 704

  Fly   570 GPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAF 634
            |||||||.|:::||...|..|:..|..||:|.|.:|::|.|.|||:|||||||||||.||.||..
Zfish   705 GPVLVFEKILFKFCSDYGLSYLPLRTSIGLWTAFLCLLLVATDASSLVCYITRFTEEAFAALICI 769

  Fly   635 IFIYKAIENVMVIGKNFPVNQ-------GIYDCVCTPPIGS--------NASVIDYAKYNW---- 680
            ||||:|:|.:..:||.:|.|.       ..|.|.|:||..:        |.|...|...||
Zfish   770 IFIYEALEKLFQLGKMYPFNMHDDLNNLTFYTCQCSPPSNTTQKMEQSWNQSGFTYDTINWTELN 834

  Fly   681 -DSCESYNGTLVGGDCG--TPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFS 742
             ..|...:|..||..||  .|...:|...||:|...||.:|:.||:||...:||:.||..||||:
Zfish   835 VQDCRDLHGEFVGPACGHNGPYIPDVLFWSVILFFTTFFLSSFLKQFKTKRYFPTKVRSSISDFA 899

  Fly   743 VLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILI 807
            |.:.|..|...||.:|:|:.||.||:..:||...|||||.|..: ||.|:...|..||||.||||
Zfish   900 VFLTIMIMVLVDYLVGIPSPKLHVPDRFEPTSKNRGWLISPLGD-NPTWTLFAAAIPALLCTILI 963

  Fly   808 FMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESE 872
            ||||||||||:||||:||||||||||||.::::::.:||:||||||||||||||:||||||:|||
Zfish   964 FMDQQITAVIINRKEHKLKKGCGYHLDLLVVAVMLGVCSIMGLPWFVAATVLSISHVNSLKVESE 1028

  Fly   873 CSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDR 937
            ||||||:|:|||:||||||.::||:.:|:||.:|.:|..||||||:||||||||:||:|:|||||
Zfish  1029 CSAPGEQPKFLGIREQRVTGLMIFVLMGLSVFMTSILKFIPMPVLYGVFLYMGVSSLRGIQFFDR 1093

  Fly   938 ILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKA 1002
            |.:..||||:|||.::||.||:.:||:||::||.||::||:|| .|..:::||:|::.::.:||.
Zfish  1094 IKLFGMPAKHQPDLIYLRYVPLWKVHIFTLVQLTCLVLLWVIK-VSAAAVVFPMMVLALVFVRKL 1157

  Fly  1003 LDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAEDNHHQHPPGSGAGANYNADKSGPTTIHIPL 1067
            ||..||:|||..|||:||| :|:...||..|...|:          |.....|::.    |.||.
Zfish  1158 LDFCFTKRELSWLDDLMPE-SKKKKEDDKKKKAKEE----------AQRMMEAEEE----IEIPF 1207

  Fly  1068 SGNKTGTKGPTVNIPQEAVNRTAVWQQINKDGN--GISEQLIIPVTLKVRQINGNHAPSSATL 1128
            .|      |..:.||::.:       ||:.|.:  .||:::     .|.....|.::..||||
Zfish  1208 DG------GDQLEIPEKTI-------QISTDPSVVNISDEM-----AKTAAWKGGNSSESATL 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	503/1053 (48%)
		Band_3_cyto	167..435	CDD:284893	162/418 (39%)
		HCO3_cotransp	476..968	CDD:279322	285/513 (56%)
slc4a7	XP_021322675.1	Band_3_cyto	122..1171	CDD:331698	503/1053 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575043
Domainoid	1	1.000	594	1.000	Domainoid score	I196
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2680
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I257
OMA	1	1.010	-	-		QHG45639
OrthoDB	1	1.010	-	-		D138594at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm25027
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810